Hexarelin exhibits protective activity against cardiac ischaemia in hearts from growth hormone-deficient rats

Growth Hormone and IGF Research

Volumn 8, Issue SUPPL. 2, 1998, Pages 149-152

  Berti, F ^a   Muller E ^a   De Gennaro Colonna, V ^a   Rossoni, G ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

6 keto prostaglandin F1 ; Angiotensin II; GH deficient rats; Hexarelin; Myocardial ischaemia and reperfusion

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ANGIOTENSIN; GROWTH HORMONE; HEART RECEPTOR; HEXARELIN;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; CORONARY BLOOD VESSEL; DRUG EFFECT; GROWTH HORMONE DEFICIENCY; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HEART PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032462550     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1096-6374(98)80041-5     Document Type: Article

References (7)

1. Saccà L, Cittadini A, Fazio S. Growth hormone and the heart. Endocr Rev 1994; 15: 555-573.
2. Rosén T, Bengtsson B-Å Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990; 336: 285-288.
3. De Gennaro Colonna V, Rossoni G, Bonacci D et al. Worsening of ischemic damage in hearts from rats with selective growth hormone deficiency. Eur J Pharmacol 1996; 314: 333-338.
4. Deghenghi R, Cananzi MM, Torsello A et al. GH-releasing activity of hexarelin, a new growth hormone-releasing peptide, in infant and adult rats. Life Sci 1994; 54: 1321-1328.
5. Berti F, Rossoni G, Della Bella D et al. Nitric oxide and prostacyclin influence coronary vasomotor tone in perfused rabbit heart and modulate endothelin-1 activity. J Cardiovasc Pharmacol 1993; 22: 321-326.
6. Pradelles P, Grassi J, Maclouf J. Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay, Anal Chem 1985; 57: 1170-1173.
7. Grilli R, Bresciani E, Torsello A et al. Tissue-specific expression of GHS-receptor mRNA in the CNS and peripheral organs of the male rat. Program and Abstracts of the 79th Annual Meeting of the Endocrine Society, Minneapolis, June 1997. Bethesda: The Endocrine Society, 1997: P1-73.