Intracerebroventricular injection of capsaicin or substance P provokes the micturition reflex in the rat

International Journal of Tissue Reactions

Volumn 20, Issue 4, 1998, Pages 109-114

  Dib, B ^a   Corsi, M M ^b   Fulgenzi, A ^c   Ferrero, M E ^b   Falchi, M ^b  

^a UNIVERSITÉ LYON 1   (France)

^b UNIVERSITY OF MILAN   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; NEUROPEPTIDE; SUBSTANCE P; TACHYKININ DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MICTURITION REFLEX; NONHUMAN; RAT;

ANIMALS; BRAIN; CAPSAICIN; INJECTIONS, INTRAVENTRICULAR; MALE; RATS; REFLEX; SUBSTANCE P; TACHYKININS; URINARY BLADDER; URINATION;

EID: 0032462354     PISSN: 02500868     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Holzer P. Capsaicin: selective toxicity for thin primary sensory neurons. In: Merken H. and Hucho F. (Eds.). "Handbook of Experimental Pharmacology". Berlin, Springer Verlag, 1992, pp 418-481.
2. Holzer-Petsche U., Lembeck F. Systemic capsaicin treatment impairs the micturition reflex in the rat. Br. J. Pharmacol., 83, 935, 1984.
3. Kuo H.C. Effects of capsaicin on detrusor contractility of rats. An in vivo and isolated whole bladder study. Urol. Int., 57, 51, 1996.
4. Maggi C.A., Lippe I.T., Giuliani S. Topical versus systemic capsaicin desensitization: specific and unspecific effects as indicated by modification of reflex micturition in rats. Neuroscience, 31, 745, 1989.
5. Maggi C.A., Meli A. The role of neuropeptides in the regulation of the micturition reflex. J. Auton. Pharmacol., 6, 133, 1986.
6. Santicioli P., Maggi C.A., Meli A. The effect of capsaicin pretreatment on the cystometrograms of urethane anesthetized rats. J. Urol., 133, 700, 1985.
7. Blok B.F.M., De Weerd H., Holstege G. Ultrastructural evidence for a paucity of projections from the lumbosacral cord to the pontine micturition center or M-region in the cat. A new concept for the organization of the micturition reflex with the periaqueductal gray as central relay. J. Comp. Neurol., 359, 300, 1995.
8. Jancsó N., Jancsó-Gabor A., Szolcsahyu J. Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br. J. Pharmac. Chermother. 31, 138, 1967.
9. Dib B., Falchi M. Convulsions and death induced in rats by Tween 80 are prevented by capsaicin. Int. J. Tiss. Reac., XVIII (1), 27, 1996.
10. Panerai A.E., Martini A., Locatelli V., Mantegazza P. Capsaicin decreases b-endorphin hypothalamic concentrations in the rat. Pharmacol. Res. Commun., 15, 825, 1983.
11. Ritter S., Dinh T.T. Capsaicin induced neuronal degenaration: silver impregnation of cell bodies, axons, and terminals in the central nervous system of the adult rat. J. Comp. Neurol., 271, 79, 1988.
12. Yaksh T.L, Farb D.H., Leeman S.E., Jessel T.M. Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia. Science, 206, 481, 1979.
13. Hajos M., Svensson K., Nissbrandt H., Obal F., Carlsson A. Effects of capsaicin on central monoaminergic mechanisms in the rat. J. Neural. Trans., 66, 221, 1986.
14. Szikszay M., London E.D. Effects of subacute capsaicin treatment on local cerebral glucose utilization in the rat. Neuroscience, 25, 917, 1988.
15. Griffits D., Holstege E., Dalm E., De Wall H. Control and coordination of bladder and urethral function in the brainstem of the cat. Neurol. Urodynam., 9, 63, 1990.
16. Lecci A., Giuliani S., Meini S., Maggi C.A. Pharmacological analysis of the local and reflex responses to bradikynin on rat urinary bladder motrility in vivo. Br. J. Pharmacol., 114, 708, 1995.
17. Palea S., Dalforno G., Gaviraghi G. Further studies on the effects of selective neurokinin agonist upon the activation of micturition reflex in rats. Evidence for a dual NK-1 receptor mediated excitatory and inhibitory activity. Neuropeptides, 24, 285, 1993.
18. Holstege G. The emotional motor system. Eur. J. Morphol., 30, 67, 1992.
19. Lecci A., Maggi C.A Spinal cord tachykinins in the micturition reflex. Prog. Brain. Res., 104, 145, 1995.