Oxidative stress may be a causal factor in senescence

Journal of the American Aging Association

Volumn 21, Issue 2, 1998, Pages 81-82

  Sohal, Rajindar S ^a   Orr, William C ^a  

^a SOUTHERN METHODIST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AEROBIC METABOLISM; HUMAN; NONHUMAN; OXIDATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; SENESCENCE; SHORT SURVEY;

EID: 0032462330     PISSN: 01619152     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11357-998-0010-z     Document Type: Article

References (8)

1. Ku, H-H., Brunk, UT. & Sohal, R.S. (1993) Relationship between mitochondrial Superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radic. Biol. Med. 15, 621-627.
2. Orr, W.C. & Sohal, R.S. (1994) Extension of life-span by overexpression of Superoxide dismutase and catalase in Drosophila melanogaster. Science 263, 1128-1130.
3. Sohal, R.S., Agarwal, S., Dubey, A. & Orr, W.C. (1993) Protein oxidative damage is associated with life expectancy of houseflies. Proc. Natl. Acad. Sci. USA 90, 7255-7259.
4. Sohal, R.S., Ku. H.-H., Agarwal, S., Forster, M.J. & Lal, H. (1994) Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech. Ageing Develop 74, 121-133.
5. Sohal, R.S., Sohal, B.H. & Orr, W.C. (1995a) Mitochondrial Superoxide and hydrogen peroxidegeneration, protein oxidative damage, and longevity in different species of flies. Free Radic. Biol. Med. 19, 499-504.
6. Sohal, R.S., Agarwal, A., Agarwal, S. & Orr, W.C. (1995b) Simultaneous overexpression of Cu,Zn superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster. J. Biol. Chem. 270, 15671-15674.
7. Sohal, R.S. & Weindruch, R. (1996) Oxidative stress, caloric restriction, and aging. Science 273, 59-63.
8. Stadtman, E.R. (1992) Protein oxidation and aging. Science 257, 1220-122