Synthesis of N-(4-aryl-1-piperazinylbutyl)-substituted 7,8-benzo-1,3-diazaspiro[4,5]decane-2,4-dione derivatives with potential anxiolytic activity

Farmaco

Volumn 53, Issue 2, 1998, Pages 169-171

  Kossakowski, Jerzy ^a   Zawadowski, Teodor ^a   Turło, Jadwiga ^a   Kleps, Jerzy ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

7,8 Benzo 1,3 diazaspiro 4,5 decane 2,4 dione derivatives; Anxiolytics

Indexed keywords

1,3 DIAZASPIRO[4,5]DECANE 2,4 DIONE DERIVATIVE; ANXIOLYTIC AGENT; IMIDE; NITROGEN; PIPERAZINE DERIVATIVE; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; NONHUMAN; RAT; RECEPTOR AFFINITY; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; BENZOQUINONES; RATS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1;

EID: 0032462324     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0014-827x(98)00010-x     Document Type: Article

References (13)

1. T. Zawadowski, J. Kossakowski, S. Rump, I. Jakowicz, A. Płaźnik, Synthesis and anxiolitic activity of N-substituted cyclic imides; N-{4-[(4-aryl)-1-piperazinyl]alkyl}-5,7-dioxabicyclo[2.2.2]octane-2,3- dicarboximide, Acta Polon. Pharm. 52 (1995) 43-46.
2. T. Zawadowski, J. Kossakowski, S. Rump, I. Jakowicz, A. Płaźnik, Synthesis and anxiolitic activity of N-substituted cyclic imides; N-(4-[(4-aryl)-1-piperazinyl]alkyl}-5,7-dioxabicyclo[2.2.2]octane-2,3- dicarboximide, Chem. Abstr. 123 (1995) 285901n.
3. J. Turło, T. Zawadowski, S. Rump, I. Jakowicz, T. Gidyńska, E. Gałecka, Synthesis and pharmacological screening of some N,N′-bis-[4-(4-aryl-1-piperazinyl)butyl]-substituted derivatives of 1,8-dimethyl-bicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxydiimide, Pol. J. Pharmacol. 46 (1994) 451-455.
4. J. Turło, T. Zawadowski, S. Rump, I. Jakowicz, T. Gidyńska, E. Gałecka, Synthesis and pharmacological screening of some N,N′-bis-[4-(4-aryl-1-piperazinyl)butyl]-substituted derivatives of 1,8-dimethyl-bicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxydiimide, Chem. Abstr. 122 (1995) 265332d.
5. T. Zawadowski, A. Skowron, S. Suski, S. Rump, I. Jakowicz, Synthesis and pharmacological profile of bicyclo[2.2.2]octane derivatives: N-(1-aryl-4-piperazinylbutyl) derivatives of 7-isopropyl-6-methyl-and 1-isopropyl-4-methylbicyclo[2.2.2]oct-5-ene-2,3-dicarboximide, Acta Polon. Pharm. 52 (1995) 129-132.
6. T. Zawadowski, A. Skowron, S. Suski, S. Rump, I. Jakowicz, Synthesis and pharmacological profile of bicyclo[2.2.2]octane derivatives: N-(1-aryl-4-piperazinylbutyl) derivatives of 7-isopropyl-6-methyl-and 1-isopropyl-4-methylbicyclo[2.2.2]oct-5-ene-2,3-dicarboximide, Chem. Abstr. 123 (1995) 340034j.
7. T. Zawadowski, J. Kossakowski, A. Skowron, S. Rump, I. Jakowicz, Preparation of N-(4-piperazinobutyl)-1-isopropyl-4-methylbicyclo[2.2.2]oct-5-ene-2,3- dicarboximides, Patent No. PL 168594.
8. T. Zawadowski, J. Kossakowski, A. Skowron, S. Rump, I. Jakowicz, Preparation of N-(4-piperazinobutyl)-1-isopropyl-4-methylbicyclo[2.2.2]oct-5-ene-2,3- dicarboximides, Chem. Abstr. 125 (1996) 86685m.
9. T. Zawadowski, J. Kossakowski, A. Skowron, S. Rump, I. Jakowicz, Preparation of N-(4-piperazinobutyl)-5,7-dioxobicyclo[2.2.2]octane-2,3-dicarboximides, Patent No. PL 168608.
10. T. Zawadowski, J. Kossakowski, A. Skowron, S. Rump, I. Jakowicz, Preparation of N-(4-piperazinobutyl)-5,7-dioxobicyclo[2.2.2]octane-2,3-dicarboximides, Chem. Abstr. 125 (1996) 86686n.
11. K. Ishizumi, A. Kojima, F. Antoku, Synthesis and anxiolytic activity of N-substituted cyclic imides (1R*,2S*,3R*,4S*)-N-{4-[4-(2-pyrimidinyl)-1-piperazinyl] butyl}-2,3-bicyclo[2.2.1]heptanedicarboxyimide (Tandospirone) and related compounds, Chem. Pharm. Bull. 39 (9) (1991) 2288-2300.
12. A. Pazos, D. Hoyer, J.M. Palacios, The binding of serotonergic ligands to the porcine chorioid plexus: characterisation of anew type of serotonin recognition site, Eur. J. Pharmacol. 106 (1984) 539-546.
13. P.J. Munson, Ligand: data analysis and curve-fitting for ligandbinding experiments. National Institutes of Health, Bethseda, 1987.