Effect of Emblica officinalis extract on hepatocarcinogenesis and carcinogen metabolism

Journal of Clinical Biochemistry and Nutrition

Volumn 25, Issue 1, 1998, Pages 31-39

  Jose, Jeena K ^a   Kuttan, Ramadasan ^a   Bhattacharya, Ratin Kumar ^b  

^a AMALA CANCER RESEARCH CENTRE   (India)

^b BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Emblica officinalis; Hepatocarcinogenesis; N nitrosodiethylamine

Indexed keywords

ANIMALIA; EMBLICA; EMBLICA OFFICINALIS; PHYLLANTHUS EMBLICA;

EID: 0032462128     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.25.31     Document Type: Article

References (21)

1. Wattenberg, L.W. (1985): Chemoprevention of cancer. Cancer Res., 45, 1-8.
2. Essigman, J.M., Croy, R.G., Bennet, R.A., and Wogan, G.N. (1982): Metabolic activation of aflatoxin B1: Patterns of DNA-adduct formation, removal and excretion in relation to carcinogenesis. Drug Metab. Rev., 13, 581-602.
3. Burgess, J.A., Stevens, C.W., and Fahl, W.E. (1985): Mutation at separate gene loci in Salmonella typhymurium TA 100 related to DNA molecule. Cancer Res., 45, 4257-4262.
4. Cerutti, P.A. (1985): Pro-oxidant states and tumor promotion. Science, 227, 375-381.
5. Sun, Y. (1990): Free radicals, antioxidant enzymes and carcinogenesis. Free Radic. Biol. Med., 8, 583-599.
6. Thakur, C.P., Thakur, B., Sinha, P.K., and Sinha, S.K. (1988): The Aurvedic medicines Haritaki, Amlaki and Bahira reduce cholesterol-induced atherosclerosis in rabbits. Int. J. Cardiol., 21, 167-175.
7. De, S., Ravishankar, B., and Bhavsar, G.C. (1993): Plants with hepatoprotective activity - A review. Indian Drugs, 30, 355-363.
8. Jose, J.K., and Kuttan, R. (1995): Antioxidant activity of Emblica officinalis. J. Clin. Biochem. Nutr., 19, 63-70.
9. Jose, J.K., Kuttan, G., George, J., and Kuttan, R. (1997): Antimutagenic and anticarcinogenic activity of Emblica officinalis Gaertn. J. Clin. Biochem. Nutr., 22, 171-176.
10. Narurkar, L.M., and Narurkar, M.V. (1989): Role of nicotinamide in suppression of diethylnitrosamine hepatocarcinogenesis in rats, in Chemoprevention of Cancer, ed. by Bhide, S.V., and Maru, G.B., Omega Scientific Publishers, New Delhi, pp. 162-177.
11. Szasz, G. (1976): Reaction rate method for γ-glutamyl transferase activity in serum. Clin. Chem., 22, 2031-2055.
12. Tate, S.S., and Meister, A. (1974): Interaction of γ-glutamyl transpeptidase with amino acids, peptides, and derivatives and analogues of glutathione. J. Biol. Chem., 23, 7593-7602.
13. Mazel, P. (1971): Experiments illustrating drug metabolism in vitro, in Fundamentals of Drug Metabolism and Drug Disposition, ed. by LaDu, B.N., Mandel, H.G., and Way, E.L., Williams and Wilkins, Baltimore, pp. 546-578.
14. Habig, W.H., Pabst, M.J., and Jakoby, W.R. (1974): Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. J. Biol. Chem., 249, 7130-7139.
15. Moron, M.A., DePierre, J.W., and Mannervick, B. (1979): Levels of glutathione, glutathione reductase, and glutathione-S-transferase activities in rat liver. Biochim. Biophys. Acta, 582, 67-78.
16. Shah, G.M., and Bhattacharya, R.K. (1982): In vivo effect of L-ascorbic acid on benzo(a)-pyrene metabolite-DNA adduct formation in rat liver. J. Biosci., 4, 263-268.
17. Shah, G.M., and Bhattacharya, R.K. (1986): Modulation by plant flavonoids and related phenolics of microsome catalysed adduct formation between B(a)P and DNA. Chem. Biol. Interact., 59, 1-5.
18. Bhattacharya, R.K., Firozi, P.F., and Aboobaker, V.S. (1984): Factors modulating the formation of DNA adduct by aflatoxin B1 in vitro. Carcinogenesis, 5, 1359-1362.
19. Conney, A.H. (1982): Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic hydrocarbons. Cancer Res., 42, 4875-4917.
20. Ghosal, S., Tripathi, V.K., and Satish, C. (1996): Active constituents of Emblica officinalis: Part 1. The chemistry and antioxidative effects of two new hydrolysable tannins, Emblicanin A and B. Indian J. Chem., 35, 941-948.
21. Brahmachari, H.D., and Gupta, V.S. (1958): Studies on Phyllanthus emblica (Amla): Part III. Role of tannins in stabilizing the ascorbic acid of the fruit. Indian J. Appl. Chem., 21, 173-174.