Ratio of free-to-total prostate specific antigen in serum cannot distinguish patients with prostate cancer from those with chronic inflammation of the prostate

Journal of Urology

Volumn 159, Issue 5, 1998, Pages 1595-1598

  Jung, Klaus ^a   Meyer, Annette ^a   Lein, Michael ^a   Rudolph, Birgit ^a   Schnorr, Dietmar ^a   Loening, Stephan A ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Carcinoma; Inflammation; Prostate; Prostate specific antigen; Prostatic hypertrophy

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; ANTIGEN DETECTION; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE BIOPSY; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN BLOOD LEVEL; RELIABILITY;

EID: 0032459838     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005392-199805000-00050     Document Type: Article

References (22)

1. Catalona, W. J.: Clinical utility of measurements of free and total prostate-specific antigen (PSA): a review. Prostate, suppl., 7: 64, 1996.
2. Van Iersel, M. P., Witjes, W. P. J., Thomas, C. M. G., Segers, M. F. G., Oosterhof, G. O. N. and Debruyne, F. M. J.: Review on the simultaneous determination of total prostate-specific antigen and free prostate-specific antigen. Prostate, suppl., 7: 48, 1996.
3. Bunting, P. S.: A guide to the interpretation of serum prostate specific antigen levels. Clin. Biochem., 28: 221, 1995.
4. Neal, D. E., Jr., Clejan, S., Sarma, D. and Moon, T. D.: Prostate specific antigen and prostatitis. I. Effect of prostatitis on serum PSA in the human and nonhuman primate. Prostate, 20: 105, 1992.
5. Brawn, P. N., Speights, V. O., Kuhl, D., Riggs, M., Spiekerman, A. M., McCord, R. G., Coffield, K. S., Stewart, D. T. and Lind, M. L.: Prostate-specific antigen levels from completely sectioned, clinically benign, whole prostates. Cancer, 68: 1592, 1991.
6. Bare, R., Hart, L. and McCullough, D. L.: Correlation of prostate-specific antigen and prostate-specific antigen density with outcome of prostate biopsy. Urology, 43: 191, 1994.
7. Nadler, R. B., Humphrey, P. A., Smith, D. S., Catalona, W. J. and Ratliff, T. L.: Effect of inflammation and benign prostatic hyperplasia on elevated serum prostate specific antigen levels. J. Urol., 154: 407, 1995.
8. Pansadoro, V., Emiliozzi, P., Defidio, L., Scarpone, P., Sabatini, G., Brisciani, A. and Lauretti, S.: Prostate-specific antigen and prostatitis in men under fifty. Eur. Urol., 30: 24, 1996.
9. Van Iersel, M. P., Witjes, W. P., de la Rosette, J. J. and Oosterhof, G. O.: Prostate-specific antigen density: correlation with histological diagnosis of prostate cancer, benign prostatic hyperplasia and prostatitis. Brit. J. Urol., 76: 47, 1995.
10. Hasui, Y., Marutsuka, K., Asada, Y., Ide, H., Nishi, S. and Osada, Y.: Relationship between serum prostate specific antigen and histological prostatitis in patients with benign prostatic hyperplasia. Prostate, 25: 91, 1994.
11. Irani, J., Levillain, P., Goujon, J.-M., Bon, D., Dore, B. and Aubert, J.: Inflammation in benign prostatic hyperplasia: correlation with prostate specific antigen value. J. Urol., 157: 1301, 1997.
12. Partin, A. W., Catalona, W. J., Southwick, P. C., Subong, E. N. P., Gasior, G. H. and Chan, D. W.: Analysis of percent free prostate-specific antigen (PSA) for prostate cancer detection: influence of total PSA, prostate volume, and age. Urology, suppl. 6A, 48: 55, 1996.
13. Vashi, A., Wojno, K. J., Henricks, W., England, B. A., Vessella, R. L., Lange, P. H., Wright, G. L. J., Schellhammer, P. F., Weigand, R. A., Olson, C. V., Dowell, B. L., Borden, K. K. and Oesterling, J. E.: Determination of the " reflex range" and appropriate cutpoints for % free PSA in 413 men referred for prostate evaluation using the AxSYM SYSTEM. Urology, 49: 19, 1997.
14. Jung, K., Stephan, C., Lein, M., Henke, W., Schnorr, D., Brux, B., Schürenkämper, P. and Loening, S. A.: Analytical performance and clinical validity of two free prostate-specific antigen assays compared. Clin. Chem., 42: 1026, 1996.
15. Kairisto, V., Poola, A.: Software for illustrative presentation of basic clinical characteristics of laboratory test - GraphROC for Windows. Scand. J. Clin. Lab. Invest., suppl. 222, 55: 43, 1995.
16. Bostwick, D. G.: Prostate-specific antigen. Current role in diagnostic pathology of prostate cancer. Amer. J. Clin. Path., 102: S31, 1994.
17. Palou, J., Morote, J.: Elevated serum PSA and acute bacterial prostatitis. Letter to the Editor. Urology, 35: 373, 1990.
18. 1-antichymotrypsin as an indicator of prostate cancer. J. Urol., 150: 100, 1993.
19. Björk, T., Hulkko, S., Bjartell, A., di Sant'Agnese, A., Abrahamsson, P. A. and Lilja, H.: Alpha 1-antichymotrypsin production in PSA-producing cells is common in prostate cancer but rare in benign prostatic hyperplasia. Urology, 43: 427, 1994.
20. Huber, P. R., Schmid, H. P., Mattarelli, G., Strittmatter, B., Vansteenbrugge, G. J. and Maurer, A.: Serum free prostate specific antigen: isoenzymes in benign hyperplasia and cancer of the prostate. Prostate, 27: 212, 1995.
21. Chen, Z., Chen, H. and Stamey, T. A.: Prostate specific antigen in benign prostatic hyperplasia: purification and characterization. J. Urol., 157: 2166, 1997.
22. Leinonen, J., Zhang, W. M. and Stenman, U. H.: Complex formation between PSA isoenzymes and protease inhibitors. J. Urol., 155: 1099, 1996.