Androgen effects on hair growth

Dermatologic Therapy

Volumn 8, Issue , 1998, Pages 7-17

  Messenger, Andrew G ^b  

^a ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; ANDROGEN; PRASTERONE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE 17BETA DEHYDROGENASE;

ALOPECIA; ANDROGEN METABOLISM; ANDROGEN SYNTHESIS; GROWTH REGULATION; HAIR GROWTH; HORMONAL REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PATHOPHYSIOLOGY; PREVALENCE; REVIEW;

EID: 0032458826     PISSN: 13960296     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (72)

1. Ebling FJG. The hormonal control of hair growth. In: Orfanos CE, Happle R, ed. Hair and hair diseases. Berlin, Springer-Verlag, 1990: 267-299.
2. Bagatell CJ, Dahl KD, Bremner WJ. The direct pituitary effect of testosterone to inhibit gonadotropin secretion in men is partially mediated by aromatization to estradiol. J Androl 1994: 15: 15-21.
3. Bhatnagar AS, Muller P, Schenkel L, Trunet PF, Beh I, Schieweck K. Inhibition of estrogen biosynthesis and its consequences on gonadotrophin secretion in the male. J Steroid Biochem Mol Biol 1992: 41: 437-443.
4. Scanlon MF. Ovary, hirsutism and virilism. In: Hall R, Besser M, ed. Fundamentals of clinical endocrinology. Edinburgh: Churchill Livingstone, 1989: 205-235.
5. Hay JB, Hodgins MB. The androgen metabolism of human skin. J Endocrinol 1971: 51: 23-24.
6. Labrie F, Luu-The V, Lin SX, Labrie C, Simard J, Breton R, Belanger A. The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology. Steroids 1997: 62: 148-158.
7. Courchay G, Boyera N, Bernard BA, Mahe Y. Messenger RNA expression of steroidogenesis enzyme subtypes in the human pilosebaceous unit. Skin Pharmacol 1996: 9: 169-176.
8. Imperato-McGinley J, Guerrero L, Gautier T, Peterson RE. Steroid 5α-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science 1974: 186: 1213-1215.
9. Peterson RE, Imperato-McGinley J, Gautier T, Sturla E. Male pseudohermaphroditism due to steroid 5α-reductase deficiency. Am J Med 1977: 62: 170-191.
10. Akgun S, Ertel NH, Imperato-McGinley J, Sayli BS, Shackleton CH. Familial male pseudohermaphroditism due to 5α-reductase deficiency in a Turkish village. Am J Med 1986: 81: 267-274.
11. Imperato-McGinley J, Miller M, Wilson JD, Peterson RE, Shackleton C, Gajdusek DC. A cluster of male pseudohermaphrodites with 5-alpha-reductase deficiency in Papua New Guinea. Clin Endocrinol (Oxf) 1991: 34: 293-298.
12. Imperato-McGinley J, Gautier T, Cai LQ, Yee B, Epstein J, Pochi P. The androgen control of sebum production. Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity. J Clin Endocrinol Metab 1993: 76: 524-528.
13. Rittmaster RS, Uno H, Povar ML, Mellin TN, Loriaux DL. The effects of N,N-diethyl-4-methyl-3-oxo-4-aza-5 alpha-androstane-17 beta carboxamide, a 5 alpha-reductase inhibitor and anti-androgen, on the development of baldness in the stumptail macaque. J Clin Endocrinol Metab 1987: 65: 188.
14. Diani AR, Mulholland MJ, Shull KL, Johnson GA, Schostarez HJ, Brunden MN, Buhl AE. Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque. J Clin Endocrinol Metab 1992: 74: 345-350.
15. Jenkins EP, Andersson S, Imperato-McGinley J, Wilson JD, Russell DW. Genetic and pharmacological evidence for more than one human steroid 5-alpha-reductase. J Clin Invest 1992: 89: 293-300.
16. Andersson S, Berman DM, Jenkins EP, Russell DW. Deletion of steroid 5-alpha-reductase 2 gene in male pseudohermaphroditism. Nature 1991: 354: 159-161.
17. Cai LQ, Zhu YS, Katz MD, Herrera C, Baez J, DeFillo-Ricart M, Shackleton CH, Imperato-McGinley J. 5-alpha-reductase-2 gene mutations in the Dominican Republic. J Clin Endocrinol Metab 1996: 81: 1730-1735.
18. Williams GR, Franklyn JA. Physiology of the steroid-thyroid hormone nuclear receptor superfamily. Baillieres Clin Endocrinol Metab 1994: 8: 241-266.
19. Patterson MN, McPhaul MJ, Hughes IA. Androgen insensitivity syndrome. Baillieres Clin Endocrinol Metab 1994: 8: 379-404.
20. Blok GJ, de Boer H, Gooren LJ, van der Veen EA. Growth hormone substitution in adult growth hormone-deficient men augments androgen effects on the skin. Clin Endocrinol (Oxf) 1997: 47: 29-36.
21. Hamilton JB. Age, sex and genetic factors in the regulation of hair growth in men: a comparison of Caucasian and Japanese populations. In: Montagna W, Ellis RA, ed. The biology of hair growth. New York: Academic Press, 1958: 399.
22. Pochi PE, Strauss JS, Downing DT. Age-related changes in sebaceous gland activity. J Invest Dermatol 1979: 73: 108-111.
23. Setty LR. Hair patterns on the scalp of white and negro males. Am J Phys Anthropol 1970: 33: 49-55.
24. Danforth CH, Trotter M. The distribution of body hair in white subjects. Am J Phys Anthropol 1922: 5: 259-265.
25. Hamilton JB. Male hormone is pre-requisite and an incitant in common baldness. Am J Anat 1942: 71: 451-480.
26. Hamilton JB. Patterned hair loss in man: types and incidence. Ann N Y Acad Sci 1951: 53: 708-728.
27. Norwood OT. Male pattern baldness: classification and incidence. South Med J 1975: 68: 1359-1365.
28. Takashima I, Iju M, Sudo M. Alopecia androgenetica - its incidence in Japanese and associated conditions. In: Orfanos CE, Montagna W, Stuttgen G, ed. Hair research status and future aspects. New York: Springer-Verlag, 1981: 287-293.
29. Courtois M, Loussouarn G, Hourseau C, Grollier JF. Ageing and hair cycles. Br J Dermatol 1995: 132: 86-93.
30. Whiting DA. Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia. J Am Acad Dermatol 1993: 28: 755-763.
31. Jaworsky C, Kligman AM, Murphy GE Characterization of inflammatory infiltrates in male pattern alopecia: implications for pathogenesis. Br J Dermatol 1992: 127: 239-246.
32. Osborn D. Inheritance of baldness. J Hered 1916: 7: 347-355.
33. Carey AH, Chan KL, Short F, White D, Williamson R, Franks S. Evidence for a single gene effect causing polycystic ovaries and male pattern baldness. Clin Endocrinol (Oxf) 1993: 38: 653-658.
34. Carey AH, Waterworth D, Patel K, White D, Little J, Novelli P, Franks S, Williamson R. Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17. Hum Mol Genet 1994: 3: 1873-1876.
35. Smith MA, Wells RS. Male-type alopecia, alopecia areata, and normal hair in women. Arch Dermatol 1964: 89: 155-158.
36. Küster W, Happle R. The inheritance of common baldness: two B or not two B? J Am Acad Dermatol 1984: 11: 921-926.
37. Harris H. The inheritance of premature baldness in men. Ann Eugenics 1946: 13: 172-181.
38. Mortimer CH, Rushton H, James KC. Effective medical treatment for baldness in women. Clin Exp Dermatol 1984: 9: 342.
39. Ludwig E. Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex. Br J Dermatol 1977: 97: 247-254.
40. Yenning VA, Dawber RP. Patterned androgenic alopecia in women. J Am Acad Dermatol 1988: 18: 1073-1077.
41. Snyder LH, Yingling HC. Studies in human inheritance. XII. The application of the gene-frequency method of analysis to sex-influenced factors, with especial reference to baldness. Hum Biol 1935: 7: 608-815.
42. Futterweit MD, Dunaif A, Yeh H-C, Kingsley P. The prevalence of hyperandrogenism in 109 consecutive female patients with difuse alopecia. J Am Acad Dermatol 1988: 19: 831-836.
43. Rushton DH, Ramsay ID, James KC, Norris MJ, Gilkes JJ. Biochemical and trichological characterization of diffuse alopecia in women. Br J Dermatol 1990: 123: 187-197.
44. Nordström REA. Synchronous balding of scalp and hair-bearing grafts of scalp transplanted to the skin of the arm in male pattern baldness. Acta Derm Venereol (Stockh) 1979: 59: 266-268.
45. Ebling FJ, Thomas AK, Cooke ID, Randall VA, Skinner J, Cawood M. Effect of cyproterone acetate on hair growth, sebaceous secretion and endocrine parameters in a hirsute subject. Br J Dermatol 1977: 97: 371-381.
46. 14C by rat skin: variations during the hair cycle. Endocrinology 1971: 89: 1506-1514.
47. Rampini E, Davis BP, Moretti G, Hsia SL. Cyclic changes in the metabolism of estradiol by rat skin during the hair cycle. J Invest Dermatol 1971: 57: 75-80.
48. Jahoda CA. Induction of follicle formation and hair growth by vibrissa dermal papillae implanted into rat ear wounds: vibrissa-type fibres are specified. Development 1992: 115: 1103-1109.
49. Cuhna GR, Lung B. The possible influence of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild type and androgen insensitive (TFM) mice. J Exp Zool 1978: 205: 181.
50. Lasnitzki I, Mizuno T. Prostatic induction: interaction of epithelium and mesenchyme from normal wild-type mice and androgen insensitive mice with testicular feminization. J Endocrinol 1980: 85: 423.
51. Van Scott EJ, Ekel TM. Geometric relationships between the matrix of the hair bulb and its dermal papilla in normal and alopecic scalp. J Invest Dermatol 1958: 31: 281-287.
52. Ibrahim L, Wright EA. A quantitative study of hair growth using mouse and rat vibrissal follicles. I. Dermal papilla volume determines hair volume. J Embryol Exp Morphol 1982: 72: 209-224.
53. Choudhry R, Hodgins MB, Van der Kwast TH, Brinkmann AO, Boersma WJ. Localization of androgen receptors in human skin by immunohistochemistry: implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands. J Endocrinol 1992: 133: 467-475.
54. Itami S, Kurata S, Sonoda T, Takayasu S. Interaction between dermal papilla cells and follicular epithelial cells in vitro: effect of androgen. Br J Dermatol 1995: 132: 527-532.
55. Liang T, Hoyer S, Yu R, Soltani K, Lorincz AL, Hiipakka RA, Liao S. Immunocytochemical localization of androgen receptors in human skin using monoclonal antibodies against the androgen receptor. J Invest Dermatol 1993: 100: 663-666.
56. Randall VA, Thornton MJ, Messenger AG. Cultured dermal papilla cells from androgen-dependent human hair follicles (e.g. beard) contain more androgen receptors than those from non-balding areas of scalp. J Endocrinol 1992: 133: 141-147.
57. Fazekas AG, Sandor T. Metabolism of androgens by isolated human hair follicles. J Steroid Biochem 1972: 3: 485-491.
58. 3H in the isolated hair follicle of man. J Clin Endocrinol Metab 1972: 34: 512-515.
59. Schweikert HU, Wilson JD. Regulation of hair growth by steroid hormones. I. Testosterone metabolism in isolated hairs. J Clin Endocrinol Metab 1974: 38: 811-819.
60. Thornton MJ, Laing I, Hamada K, Messenger AG, Randall VA. Differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells. Clin Endocrinol (Oxf) 1993: 39: 633-639.
61. Itami S, Kurata S, Sonoda T, Takayasu S. Characterization of 5 alpha-reductase in cultured human dermal papilla cells from beard and occipital scalp hair. J Invest Dermatol 1991: 96: 57-40.
62. Harris G, Azzolina B, Baginsky W, Cimis G, Rasmusson GH, Tolman RL, Raetz RH, Ellsworth K. Identification and selective inhibition of an isozyme of steroid 5α-reductase in human scalp. Proc Natl Acad Sci U S A 1998: 89: 10787-10791.
63. Sawaya ME, Price VH. Different levels of 5 alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol 1997: 109: 296-300.
64. Eicheler W, Dreher M, Hoffman R, Happle R, Aumuller G. Immunohistochemical evidence for differential distribution of 5 alpha-reductase isoenzymes in human skin. Br J Dermatol 1995: 133: 371-376.
65. Itami S, Kurata S, Takayasu S. Androgen induction of follicular epithelial cell growth is mediated via insulin-like growth factor 1 from dermal papilla cells. Biochem Biophys Res Commun 1995: 212: 988-994.
66. Obana N, Chang C, Uno H. Inhibition of hair growth by testosterone in the presence of dermal papilla cells from the frontal bald scalp of the postpubertal stumptailed macaque. Endocrinology 1997: 138: 356-361.
67. Elliott K, Stephenson TJ, Messenger AG. Geometric relationships in the human hair follicle: interfollicular differences in dermal papilla volume are determined by cell number. Br J Dermatol 1997: 136: 443.
68. Uno H, Adachi K, Montagna W. Morphological and biochemical studies of hair follicle in common baldness of stump-tailed macaque (Macaca speciosa). In: Montagna W, Dobson RL, ed. Hair growth, advances in biology of skin, vol. 9. Oxford: Pergamon Press, 1969: 221-245.
69. Hamilton JB. A male pattern baldness in wattled starlings resembling the condition in man. Ann N Y Acad Sci 1959: 83: 429-447.
70. Matias JR, Malloy V, Orentreich N. Animal models of androgen-dependent disorders of the pilosebaceous apparatus. 1. The androchronogenetic alopecia (AGA) mouse as a model for male-pattern baldness. Arch Dermatol Res 1989: 281: 247-253.
71. Randall VA, Thornton MJ, Messenger AG. Variations in androgen receptor content of dermal papilla cells cultured from human and red deer (Cervus elaphus) hair follicles. J Invest Dermatol 1993: 101: 1145-1205.
72. Van Neste D, De Brouwer B, Tételin C, Bonfils A. Testosterone conditioned nude mice: an improved model for experimental monitoring of human hair production by androgen dependent balding scalp grafts. In: Van Neste D, Randall VA, ed. Hair research for the next millenium. Amsterdam: Elsevier, 1996: 319-322.