Structure-activity relationship investigations of the modulating effect of core substituents on the affinity of pyrazoloquinolinone congeners for the benzodiazepine receptor

Farmaco

Volumn 53, Issue 8-9, 1998, Pages 579-585

  Karolak Wojciechowska, Janina ^a   Lange, Jerzy ^b   Ksia̧zek, Waldemar ^a   Gniewosz, Malgorzata ^b   Rump, Sławomir ^c  

^a LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

^b WARSAW UNIVERSITY OF TECHNOLOGY   (Poland)

^c MILITARY INSTITUTE OF HYGIENE AND EPIDEMIOLOGY   (Poland)

Author keywords

Benzodiazepine receptor; Pyrazoloquinolinones; QSAR; Substituent effects

Indexed keywords

BENZODIAZEPINE RECEPTOR; FLUNITRAZEPAM; PYRAZOLONE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; DIPOLE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HYDROPHOBICITY; IONIZATION; LIPOPHILICITY; NONHUMAN; PARTITION COEFFICIENT; QUANTUM CHEMISTRY; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

BINDING, COMPETITIVE; ELECTROSTATICS; FLUNITRAZEPAM; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; QUINOLONES; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032456986     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(98)00072-X     Document Type: Article

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