A NMR and MD study of the active site of factor Xa by selective inhibitors

Journal de Chimie Physique et de Physico-Chimie Biologique

Volumn 95, Issue 2, 1998, Pages 443-446

  Doan, B T ^a,c   Fraternali, F ^a,d   Do, Q T ^a,e   Atkinson, R A ^a,f   Palmas, P ^a,g   Sklenar, V ^a,h   Wildgoose, P ^a   Strop, P ^b   Saudek, V ^a  

^a SANOFI   (France)

^b Selectide Corporation   (United States)

^c SORBONNE UNIVERSITÉ   (France)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^e Tripos Associates   (France)

^f UNIVERSITÉ DE STRASBOURG   (France)

^g DIF   (France)

^h MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Factor Xa; Inhibitors; Simulated Annealing; Transfer NOE

Indexed keywords

BLOOD CLOTTING FACTOR 10A; ENZYME INHIBITOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME SPECIFICITY; HYDROGEN BOND; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT;

EID: 0032456259     PISSN: 00217689     EISSN: None     Source Type: Journal    
DOI: 10.1051/jcp:1998158     Document Type: Article

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