Erdosteine enhances mucociliary clearance in rats with and without airway inflammation

Journal of Pharmacological and Toxicological Methods

Volumn 40, Issue 3, 1998, Pages 165-171

  Hosoe, Hisashi ^a   Kaise, Toshihiko ^a   Ohmori, Kenji ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Anti inflammatory; Mucociliary transport; Mucolytics; Pulmonary emphysema; Thiol derivatives

Indexed keywords

AMBROXOL; CARBOCISTEINE; ERDOSTEINE; GLYCOSAMINOGLYCAN; MUCOLYTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; LUNG EMPHYSEMA; LUNG LAVAGE; MALE; MUCOCILIARY CLEARANCE; MUCOCILIARY TRANSPORT; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RESPIRATORY TRACT INFLAMMATION;

ALBUMINS; AMBROXOL; ANIMALS; BRONCHI; BRONCHITIS; BRONCHOALVEOLAR LAVAGE FLUID; CARBOCYSTEINE; CARBON; EXPECTORANTS; GLYCOSAMINOGLYCANS; LIPOPOLYSACCHARIDES; MALE; MUCOCILIARY CLEARANCE; PARTICLE SIZE; RATS; RATS, WISTAR; THIOGLYCOLATES; THIOPHENES; TIME FACTORS;

EID: 0032455884     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(98)00053-7     Document Type: Article

References (40)

1. Achterrath-Tuckermann U, Saano V, Minker E, Stroman F, Arny I, Joki S, Nuutinen J, Szelenyi I (1992) Influence of azelastine and some selected drug on mucociliay clearance. Lung 170:201-209.
2. Adails D, Gardner DE, Miller FJ (1978) Citotoxic effects of nickel on cilated epithelium. Am Rev Respir Dis 118:347-354.
3. Babior BM (1984) The respiratory burst of phagocytes. J Clin Invest 73:549-560.
4. Barnes PJ, Rhoden KJ (1987) The effect of oxygen-derived free radicals on airway smooth muscle responses, Br J Pharmacol 90(suppl 142).
5. Brogan TD, Ryley HC, Allen L, Hutt H (1971) Relation between sputum sol phase composition and diagnosis in chronic chest diseases. Thorax 26:418-423.
6. Camner P (1980) Clearance of particles from the human tracheobronchial tree. Clin Sci 59:79-84.
7. Chand N, Harrison JE, Rooney S, Diamantis W, Sofia RD (1993) Mucolytic activity of azelastine in mice and rats. Agents Actions 38:165-170.
8. Dalham T (1956) Mucous flow and ciliary activity in the trachea of healthy rats and rats exposed to respiratory irritant gases. Acta Physiol Scand 36:1-157.
9. Dimango E, Zar HJ, Bryan R, Prince A (1995) Diverse Pseudomonas acruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J Clin Invest 96:2204-2210.
10. Dirksen H, Hermansen F, Groth S, Molgaard F (1987) Mucociliary clearance in early simple bronchitis. Eur J Respir Dis 71:145-149.
11. Doumas BT, Biggs HG (1972) Determination of serum albumin. In Standard methods of Clinical Chemistry. Eds., GB Cooper. New York: New York Academic, pp. 175-188.
12. Freeman BA, Crapo JD (1982) Biology of disease: free radicals and tissue injury. Lab Invest 47:412-426.
13. Goldberg RL, Kolbas LM (1990) An improved method For determin-ing proteoglycans synthesized by chondrocytes in culture. Conn Tissue Res 24:265-275.
14. Grose EC, Gardner DE, Miller F (1980) Response of ciliated epithelium to ozone and sulfuric acid. Environ Res 22:377-385.
15. Hosoe H, Kaise T, Ohmori K, Kai H, Takahama K, Miyata T (1993) Pharmacological effects of KW-9144, a new cysteine derivative. Jpn J Pharmacol 61:81P.
16. Hsieh V, Amoruso-Marchat B, Rylander R, Polla BS (1994) Oxygen metabolites from lavage and interstitial lung cells after inhalation of endotoxin in guinea pigs. Int Arch Allergy Immunol 104:42-47.
17. Inglesi M, Nicola M, Fregnan GB (1994) Synthesis and free radical scavenging properties of the enantiomers of erdosteine. Farmaco 49:703-708.
18. Iravani J, Melville GN (1974) Long-term effect of cigarette smoke on mucociliary function in animals. Respiration 31:358-366.
19. Kai H, Saito M, Furusawa K, Oda Y, Okano Y, Takahama K, Miyata T (1989) Protective effects of surface-active phospholipids against the acid-inducing inhibition of the tracheal mucociliary transport. Jpn J Pharmacol 49:375-380.
20. Kai H, Yamamoto S, Takahama K, Miyata T (1990) Influence of corticosterone on trachael mucociliary transport in pigeons, Jpn J Pharmacol 52:496-499.
21. Laforna CL, Fazio F (1984) Acute effect of inhaled salbutamol on mucociliary clearance in health and chronic bronchitis. Respiration 45:111-123.
22. Milton DK, Goldeski JJ, Feldman HA, Greaves IA (1990) Toxicity of intratracheally instilled cotton dust, cellulose, and endotoxin. Am Rev Respir Dis 142:184-192.
23. Miyata T, Matsumoto N, Yuki H, Takahama K, Okano Y, Kai H (1988) The effect of N-acetylneuraminic acid on the mucociliary transport impaired by cigarette smoke. Arch Int Pharmacodyn Ther 296:202-209.
24. Morgan KT, Patterson KT, Patterson DL (1986) Distribution, progression and recovery of acute formaldehyde induced inhibition of nasal mucociliary function in F-344 rats. Toxicol Appl Pharmacol 86:448-456.
25. Ohashi Y, Nakai Y, Ikeoka H, Koshimo H, Esaki Y, Kato S (1987) Effects of bacterial endotoxin on the ciliary activity in vitro estachian tube. Arch Otorhinolaryngol 244:88-90.
26. O'Riordan TG, Zwang J, Smaldone GC (1992) Mucociliary clearance in adult asthma. Agents Actions 35:200-207.
27. Persson CGA (1987) Leakage of macromolecules from the tracheobronchial microcirculation. Am Rev Respir Dis 135:S71-75.
28. Regnis JA, Robinson M, Bailey DL, Cook P, Hooper P, Chan HK, Gonda I, Bautovich G, Bye PTP (1994) Mucociliary clearance in patients with cystic fibrosis and in normal subjects. Am J Respir Crit Care Med 150:66-71.
29. Rylander R, Baker B, Fisher JJ, Helander IM (1989) Pulmonary function and symptoms after inhalation of endotoxin. Am Rev Respir Dis 140:981-986.
30. Sanderson MJ, Sleigh MA (1981) Serum proteins agglutinate cilia and modify ciliary coordination. Pediatr Res 15:219-228.
31. Scuri R, Giannetti P, Paesano A (1988) Effect of erdosteine and its metabolites on tracheobronchial mucus production and transport. Drugs Exptl Clin Res 14:693-698.
32. Scrafini SM, Wanner A, Michaelson ED (1976) Mucociliary transport in central and intermediate size airways: effect of aminophyllin. Bull Europ Physiopath Resp 12:415-422.
33. Smart SJ, Casale TB (1993) Interleukin-8-induced transcellular neutrophil migration is facilitated by endothelial and pulmonary epithelial cells. Am J Respir Mol Biol 9:489-495.
34. Sporn, PHS, Petets-Golden M, Simon RH (1988) Hydrogen-peroxideinduced arachedonic acid metabolism in the rat alveolar macrophage. Am Rev Respir Dis 137:49-56.
35. Tai S, Kai H, Isohama Y, Takahama K, Miyata T (1996) Effect of leukotriene D4 on tracheal mucociliary transport velocity in quails. Jpn J Pharmacol 70:195-197.
36. Wanner A, Zarzecki S, Hirsch J, Epstein S (1975) Tracheal mucous transport in experimental canine asthma. J Appl Physiol 39:950-957.
37. Wanner A (1977) Clinical aspects of mucociliary transport. Am Rev Respir Dis 116:73-125.
38. Webber SE, Widdicombe JG (1989) The transport of albumin across The ferret in vitro whole trachea. J Physiol 408:457-472.
39. Weiss T, Dorow P, Felix R (1981) Effects of a beta adrenergic drug and a secretolytic agent on regional mucociliary clearance in patients with COPD. Chest 80:881-885.
40. Yoshitsugu M, Matsunaga S, Hanamura Y, Rautiainen M, Ueno K, Miyanohara T, Furuta S, Fukuda K, Ohyama M (1995) Effects of oxygen radicals on ciliary motility in cultured human respiratory epithelial cells. Auris Nasus Larynx 22:178-185.