메뉴 건너뛰기




Volumn 7, Issue 3, 1998, Pages 169-177

Free radical theory of ageing: Applications

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL;

EID: 0032455650     PISSN: 13280163     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1328-0163(98)90023-9     Document Type: Review
Times cited : (10)

References (100)
  • 1
    • 0028606516 scopus 로고
    • Aging: prospects for further increases in the functional life span
    • D. Harman Aging: prospects for further increases in the functional life span Age 17 1994 119 146
    • (1994) Age , vol.17 , pp. 119-146
    • Harman, D.1
  • 2
    • 0029743640 scopus 로고    scopus 로고
    • Aging and disease: extending the functional life span
    • D. Harman Aging and disease: extending the functional life span Ann N Y Acad Sci 786 1996 321 336
    • (1996) Ann N Y Acad Sci , vol.786 , pp. 321-336
    • Harman, D.1
  • 3
    • 0001831729 scopus 로고
    • Aging and age-related diseases: normal processes
    • R.R. Kohn Aging and age-related diseases: normal processes H.A. Johnson Relation between Normal Aging and Disease 1985 Raven Press New York 1 44
    • (1985) , pp. 1-44
    • Kohn, R.R.1
  • 4
    • 33847528434 scopus 로고
    • Befolknings-forandringar. Livslangstabeller, 1951–1993
    • Svweiges officiella statistik Befolknings-forandringar. Livslangstabeller, 1951–1993 1993 Statistiska centralbyran Stockholm, Sweden 114 115
    • (1993) , pp. 114-115
    • Svweiges officiella statistik1
  • 5
    • 0025198608 scopus 로고
    • In search of Methuselah: estimating the upper limits to human longevity
    • S.J. Olshansky B.A. Carnes C. Cassel In search of Methuselah: estimating the upper limits to human longevity Science 250 1990 634 640
    • (1990) Science , vol.250 , pp. 634-640
    • Olshansky, S.J.1    Carnes, B.A.2    Cassel, C.3
  • 6
    • 85119792895 scopus 로고
    • H.R. Warner R.N. Butler R.L. Sprott E.L. Schneider Modem Biological Theories of Aging 1987 Raven Press New York
    • (1987)
  • 7
    • 0025117953 scopus 로고
    • An attempt at a rational classification of theories of aging
    • Z.A. Medvedev An attempt at a rational classification of theories of aging Biological Rev 65 1990 375 398
    • (1990) Biological Rev , vol.65 , pp. 375-398
    • Medvedev, Z.A.1
  • 8
    • 0027023063 scopus 로고
    • Free radical theory of aging: history
    • D. Harman Free radical theory of aging: history I. Emerit B. Chance Free Radicals and Aging 1992 Birkhauser Basel 1 10
    • (1992) , pp. 1-10
    • Harman, D.1
  • 9
    • 0027354319 scopus 로고
    • Free radical involvement in aging: pathophysiology and therapeutic implications
    • D. Harman Free radical involvement in aging: pathophysiology and therapeutic implications Drugs & Aging 3 1993 60 80
    • (1993) Drugs & Aging , vol.3 , pp. 60-80
    • Harman, D.1
  • 10
    • 0020066839 scopus 로고
    • Is cell aging caused by respiratory-dependent injury to the mitochondrial genome?
    • J.E. Fleming J. Miquel S.F. Cottrell L.S. Yengoyan A.C. Economos Is cell aging caused by respiratory-dependent injury to the mitochondrial genome? Gerontol 28 1982 44 53
    • (1982) Gerontol , vol.28 , pp. 44-53
    • Fleming, J.E.1    Miquel, J.2    Cottrell, S.F.3    Yengoyan, L.S.4    Economos, A.C.5
  • 11
    • 0017810263 scopus 로고
    • Do mitochondria produce oxygen radicals in vivo?
    • H. Nohl D. Hegner Do mitochondria produce oxygen radicals in vivo? Eur J Biochem 82 1978 863 867
    • (1978) Eur J Biochem , vol.82 , pp. 863-867
    • Nohl, H.1    Hegner, D.2
  • 12
    • 0026023219 scopus 로고
    • Hydrogen peroxide release by mitochondria increases during aging
    • R.S. Sohal B.H. Sohal Hydrogen peroxide release by mitochondria increases during aging Mech Ageing Develop 57 1991 187 202
    • (1991) Mech Ageing Develop , vol.57 , pp. 187-202
    • Sohal, R.S.1    Sohal, B.H.2
  • 13
    • 0028342438 scopus 로고
    • Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
    • R.S. Sohal H.-H. Ku S. Agarwal M.J. Forster H. Lal Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse Mech Ageing Develop 74 1994 121 133
    • (1994) Mech Ageing Develop , vol.74 , pp. 121-133
    • Sohal, R.S.1    Ku, H.-H.2    Agarwal, S.3    Forster, M.J.4    Lal, H.5
  • 14
    • 0030897739 scopus 로고    scopus 로고
    • Genetic and functional changes in mitochondria associated with aging
    • T. Ozawa Genetic and functional changes in mitochondria associated with aging Physiol Rev 77 1997 425 464
    • (1997) Physiol Rev , vol.77 , pp. 425-464
    • Ozawa, T.1
  • 15
    • 0003963717 scopus 로고
    • Genesis on Planet Earth
    • W. Day Genesis on Planet Earth 1979 House of Talos East Lansing, Michigan
    • (1979)
    • Day, W.1
  • 16
    • 0003928702 scopus 로고
    • Free Radical Chemistry
    • D.C. Nonhebel J.C. Walton Free Radical Chemistry 1974 University Press Cambridge, MA
    • (1974)
    • Nonhebel, D.C.1    Walton, J.C.2
  • 17
    • 0003536299 scopus 로고
    • Free Radicals in Biology and Medicine
    • B. Halliwell J.M.C. Gutteridge Free Radicals in Biology and Medicine 2nd edition 1989 Clarendon Press Oxford 236
    • (1989) , pp. 236
    • Halliwell, B.1    Gutteridge, J.M.C.2
  • 18
    • 0001842798 scopus 로고
    • Free radical theory of aging: role of free radicals in the origination and evolution of life, aging, and disease processes
    • D. Harman Free radical theory of aging: role of free radicals in the origination and evolution of life, aging, and disease processes J.E. Johnson Jr. R. Walford D. Harman J. Miquel Free Radicals, Aging, and Degenerative Diseases 1986 Alan R Liss New York 3 49
    • (1986) , pp. 3-49
    • Harman, D.1
  • 19
    • 0020059410 scopus 로고
    • Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: longevity, growth, lean body mass and disease
    • B.P. Yu E.J. Masoro E.J. Murata H.A. Bertrand F.T. Lynd Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: longevity, growth, lean body mass and disease J Gerontol 37 1982 130 141
    • (1982) J Gerontol , vol.37 , pp. 130-141
    • Yu, B.P.1    Masoro, E.J.2    Murata, E.J.3    Bertrand, H.A.4    Lynd, F.T.5
  • 20
    • 0001596517 scopus 로고
    • A critical review of spin trapping in biological systems
    • E.G. Janzen A critical review of spin trapping in biological systems W.A. Pryor Free Radicals in Biology Vol 4 1984 Academic Press New York 115 154
    • (1984) , pp. 115-154
    • Janzen, E.G.1
  • 21
    • 0026337298 scopus 로고
    • Oxidative damage to behavior during aging
    • R.A. Floyd Oxidative damage to behavior during aging Science 254 1991 1597
    • (1991) Science , vol.254 , pp. 1597
    • Floyd, R.A.1
  • 22
    • 0011230350 scopus 로고
    • Surface localization of sites of reduction of nitroxide spin-labeled molecules in mitochondria
    • A.T. Quintanilha L. Packer Surface localization of sites of reduction of nitroxide spin-labeled molecules in mitochondria Proc Natl Acad Sci 74 1977 570 574
    • (1977) , pp. 570-574
    • Quintanilha, A.T.1    Packer, L.2
  • 23
    • 0029058728 scopus 로고
    • The spin-trap N-tert-α-butylnitrone prolongs the life span of the senescence accelerated mouse
    • R. Edamatsu A. Mori L. Packer The spin-trap N-tert-α-butylnitrone prolongs the life span of the senescence accelerated mouse Biochem Biophys Res Commun 211 1995 847 849
    • (1995) Biochem Biophys Res Commun , vol.211 , pp. 847-849
    • Edamatsu, R.1    Mori, A.2    Packer, L.3
  • 24
    • 0002982269 scopus 로고
    • Life table modification and life prolongation
    • G.A. Sacher Life table modification and life prolongation C.E. Finch L. Hayflick Handbook of the Biology of Aging 1977 Van Nostrand Reinhold New York 582 638
    • (1977) , pp. 582-638
    • Sacher, G.A.1
  • 25
    • 0027517591 scopus 로고
    • Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential
    • H.H. Ku R.S. Sohal Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential Mech Ageing Dev 72 1993 67 76
    • (1993) Mech Ageing Dev , vol.72 , pp. 67-76
    • Ku, H.H.1    Sohal, R.S.2
  • 26
    • 0028528590 scopus 로고
    • Low mitochondrial free radical production per unit 02 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds
    • 2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds Free Rad Res 21 1994 317 328
    • (1994) Free Rad Res , vol.21 , pp. 317-328
    • Barja, G.1    Cadenas, S.2    Rojas, C.3    Perez-Campo, R.4    Lopez-Torres, M.5
  • 27
    • 0010715770 scopus 로고
    • The Pineal Gland and Melatonin: Regulation and Role in Oxidative Defense, Cancer, and Aging
    • R.J. Reiter The Pineal Gland and Melatonin: Regulation and Role in Oxidative Defense, Cancer, and Aging 1994 CRC Press Boca Raton, FL
    • (1994)
    • Reiter, R.J.1
  • 28
    • 0029888128 scopus 로고    scopus 로고
    • Structure-antioxidant activity relationships of flavonoids and phenolic acids
    • C.A. Rice-Evans N.J. Miller G. Paganga Structure-antioxidant activity relationships of flavonoids and phenolic acids Free Rad Biol Med 20 1996 933 956
    • (1996) Free Rad Biol Med , vol.20 , pp. 933-956
    • Rice-Evans, C.A.1    Miller, N.J.2    Paganga, G.3
  • 30
    • 0027390271 scopus 로고
    • Inhibition of superoxide-generating NADPH oxidase of human neutrophils by lazaroids (21-aminosteroids and 2-methylaminochromans)
    • P.D/. Thomas G.D. Mao A. Rabinovitch M.J. Poznansky Inhibition of superoxide-generating NADPH oxidase of human neutrophils by lazaroids (21-aminosteroids and 2-methylaminochromans) Biochem Pharmacol 45 1993 241 251
    • (1993) Biochem Pharmacol , vol.45 , pp. 241-251
    • Thomas, P.D/.1    Mao, G.D.2    Rabinovitch, A.3    Poznansky, M.J.4
  • 31
    • 0021361978 scopus 로고
    • Genetically determined conidial longevity is positively correlated with superoxide dismutase, catalase, glutathione peroxidase, cytochrome c peroxidase, and ascorbate free radical reductase activities in Neurospora crassa
    • K.D. Munkers R.S. Rana E. Goldstein Genetically determined conidial longevity is positively correlated with superoxide dismutase, catalase, glutathione peroxidase, cytochrome c peroxidase, and ascorbate free radical reductase activities in Neurospora crassa Mech Ageing Dev 24 1984 83 100
    • (1984) Mech Ageing Dev , vol.24 , pp. 83-100
    • Munkers, K.D.1    Rana, R.S.2    Goldstein, E.3
  • 32
    • 0003316293 scopus 로고
    • Extended longevity and enhanced antioxidant defenses in Drosophila
    • S. Dwyer A. Berrios R. Arking Extended longevity and enhanced antioxidant defenses in Drosophila Gerontol 29 1989 186 (abstract)
    • (1989) Gerontol , vol.29 , pp. 186
    • Dwyer, S.1    Berrios, A.2    Arking, R.3
  • 33
    • 0026640223 scopus 로고
    • The search for the genetic basis of aging: the identification of gerontogenes in the nematode Caenorhabditis elegans
    • T.E. Johnson G.J. Lithgow The search for the genetic basis of aging: the identification of gerontogenes in the nematode Caenorhabditis elegans J Am Geriatr Soc 40 1992 936 945
    • (1992) J Am Geriatr Soc , vol.40 , pp. 936-945
    • Johnson, T.E.1    Lithgow, G.J.2
  • 34
    • 0028220114 scopus 로고
    • Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophilia melanogaster
    • W.C. Orr R.S. Sohal Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophilia melanogaster Science 263 1994 1128 1130
    • (1994) Science , vol.263 , pp. 1128-1130
    • Orr, W.C.1    Sohal, R.S.2
  • 35
    • 0014340640 scopus 로고
    • Free radical theory of aging: effect of free radical inhibitors on the mortality rate of male LAF1 mice
    • D. Harman Free radical theory of aging: effect of free radical inhibitors on the mortality rate of male LAF1 mice J Gerontol 23 1968 476 482
    • (1968) J Gerontol , vol.23 , pp. 476-482
    • Harman, D.1
  • 36
    • 0021686586 scopus 로고
    • Effect of dietary 2-mercaptoethanol on the life span, immune system, tumour incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice
    • M.L. Heidrick L.C. Hendricks D.E. Cook Effect of dietary 2-mercaptoethanol on the life span, immune system, tumour incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice Mech Ageing Dev 27 1984 341 358
    • (1984) Mech Ageing Dev , vol.27 , pp. 341-358
    • Heidrick, M.L.1    Hendricks, L.C.2    Cook, D.E.3
  • 37
    • 0017158231 scopus 로고
    • Free radicals and the action of inhibitors of radical processes under pathological states and aging in living organisms and man
    • N.M. Emanuel Free radicals and the action of inhibitors of radical processes under pathological states and aging in living organisms and man Quart Rev Biophys 9 1976 283 308
    • (1976) Quart Rev Biophys , vol.9 , pp. 283-308
    • Emanuel, N.M.1
  • 38
    • 0003216195 scopus 로고
    • Drug for prophylaxis of aging and prolongation of lifetime
    • N.M. Emanuel G. Duburs L.K. Obukhov J. Uldrikis Drug for prophylaxis of aging and prolongation of lifetime Chem Abstr 94 1981 9632a (abstract)
    • (1981) Chem Abstr , vol.94 , pp. 9632a
    • Emanuel, N.M.1    Duburs, G.2    Obukhov, L.K.3    Uldrikis, J.4
  • 42
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • S.A. Lipton P.A. Rosenberg Excitatory amino acids as a final common pathway for neurologic disorders N Engl J Med 330 1994 613 622
    • (1994) N Engl J Med , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 43
    • 0018631487 scopus 로고
    • Free radical theory of aging: beneficial effect of adding antioxidants to the maternal mouse diet on life span of offspring: possible explanation of the sex difference in longevity
    • D. Harman D.E. Eddy Free radical theory of aging: beneficial effect of adding antioxidants to the maternal mouse diet on life span of offspring: possible explanation of the sex difference in longevity Age 2 1979 109 122
    • (1979) Age , vol.2 , pp. 109-122
    • Harman, D.1    Eddy, D.E.2
  • 44
    • 0026701521 scopus 로고
    • Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence
    • G. Block B. Patterson A. Subar Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence Nutr Cancer 18 1992 1 29
    • (1992) Nutr Cancer , vol.18 , pp. 1-29
    • Block, G.1    Patterson, B.2    Subar, A.3
  • 45
    • 0023664866 scopus 로고
    • Phytic acid: a natural antioxidant
    • E. Graf K.L. Empson J.W. Eaton Phytic acid: a natural antioxidant J Biol Chem 262 1987 11647 11650
    • (1987) J Biol Chem , vol.262 , pp. 11647-11650
    • Graf, E.1    Empson, K.L.2    Eaton, J.W.3
  • 46
    • 0025967251 scopus 로고
    • Antioxidant nutrients and disease prevention: an overview
    • A.T. Diplock Antioxidant nutrients and disease prevention: an overview Am J Clin Nutr 3 Suppl 1 1991 189S 193S
    • (1991) Am J Clin Nutr , vol.3 , Issue.Suppl 1 , pp. 189S-193S
    • Diplock, A.T.1
  • 48
    • 0026577605 scopus 로고
    • A major inducer of anti-carcinogenic protective enzymes from broccoli: isolation and elucidation of structure
    • Y. Zhang P. Talalay C.-G. Cho G.H. Posner A major inducer of anti-carcinogenic protective enzymes from broccoli: isolation and elucidation of structure Proc Natl Acad Sci 89 1992 2399 2403
    • (1992) , pp. 2399-2403
    • Zhang, Y.1    Talalay, P.2    Cho, C.-G.3    Posner, G.H.4
  • 49
    • 0021741506 scopus 로고
    • Free radical theory of aging: the “free radical” diseases
    • D. Harman Free radical theory of aging: the “free radical” diseases Age 7 1984 111 131
    • (1984) Age , vol.7 , pp. 111-131
    • Harman, D.1
  • 50
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • D.R. Rosen T. Siddique D. Patterson Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 362 1993 59 62
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1    Siddique, T.2    Patterson, D.3
  • 51
    • 0025883972 scopus 로고
    • Does superoxide underlie the pathogenesis of hypertension?
    • K. Nakazono N. Watanabe K. Matsuno J. Sasaki T. Sato M. Inoue Does superoxide underlie the pathogenesis of hypertension? Proc Natl Acad Sci 88 1991 10045 10049
    • (1991) , pp. 10045-10049
    • Nakazono, K.1    Watanabe, N.2    Matsuno, K.3    Sasaki, J.4    Sato, T.5    Inoue, M.6
  • 52
    • 0021741506 scopus 로고
    • Free radical theory of aging; the “tree radical” diseases
    • D. Harman Free radical theory of aging; the “tree radical” diseases Age 7 1984 111 131
    • (1984) Age , vol.7 , pp. 111-131
    • Harman, D.1
  • 53
    • 0021964203 scopus 로고
    • Prooxidant states and tumour promotion
    • P.A. Cerutti Prooxidant states and tumour promotion Science 227 1985 375 381
    • (1985) Science , vol.227 , pp. 375-381
    • Cerutti, P.A.1
  • 54
    • 0026576932 scopus 로고
    • Vitamin C intake and mortality among a sample of the United States population
    • J.E. Enstrom L.E. Kanim M.A. Klein Vitamin C intake and mortality among a sample of the United States population Epidemiol 3 1992 194 202
    • (1992) Epidemiol , vol.3 , pp. 194-202
    • Enstrom, J.E.1    Kanim, L.E.2    Klein, M.A.3
  • 55
    • 84913629457 scopus 로고
    • Atherosclerosis: inhibiting effect of an antihistaminic drug, chlorpheniramine
    • D. Harman Atherosclerosis: inhibiting effect of an antihistaminic drug, chlorpheniramine Circulation Res 11 1962 277 282
    • (1962) Circulation Res , vol.11 , pp. 277-282
    • Harman, D.1
  • 57
    • 0010669630 scopus 로고
    • Atherosclerosis: a hypothesis concerning the initiating steps in pathogenesis
    • D. Harman Atherosclerosis: a hypothesis concerning the initiating steps in pathogenesis J Geronol 12 1957 199 202
    • (1957) J Geronol , vol.12 , pp. 199-202
    • Harman, D.1
  • 60
    • 0022616654 scopus 로고
    • Alzheimer's disease
    • R Katzman Alzheimer's disease N Engl J Med 314 1986 964 973
    • (1986) N Engl J Med , vol.314 , pp. 964-973
    • Katzman, R1
  • 62
    • 0025911018 scopus 로고
    • Advances in Alzheimer's disease
    • R. Katzman T. Saitoh Advances in Alzheimer's disease FASEB J 5 1991 278 286
    • (1991) FASEB J , vol.5 , pp. 278-286
    • Katzman, R.1    Saitoh, T.2
  • 63
    • 0026743110 scopus 로고
    • Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
    • P.V. Arriagada K. Marzloff B.T. Hyman Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease Neurol 42 1992 1681 1688
    • (1992) Neurol , vol.42 , pp. 1681-1688
    • Arriagada, P.V.1    Marzloff, K.2    Hyman, B.T.3
  • 64
    • 0029548561 scopus 로고
    • Free radical theory of aging: Alzheimer's disease pathogenesis
    • D. Harman Free radical theory of aging: Alzheimer's disease pathogenesis Age 18 1995 97 119
    • (1995) Age , vol.18 , pp. 97-119
    • Harman, D.1
  • 65
    • 0029761483 scopus 로고    scopus 로고
    • A hypothesis on the pathogenesis of Alzheimer's disease
    • D. Harman A hypothesis on the pathogenesis of Alzheimer's disease Ann N Y Acad Sci 786 1996 152 168
    • (1996) Ann N Y Acad Sci , vol.786 , pp. 152-168
    • Harman, D.1
  • 67
    • 0019434645 scopus 로고
    • Iron and the sex difference in heart disease rate
    • J.L. Sullivan Iron and the sex difference in heart disease rate Lancet 2 1981 1293 1294
    • (1981) Lancet , vol.2 , pp. 1293-1294
    • Sullivan, J.L.1
  • 68
    • 0023736197 scopus 로고
    • Nontransferrin-bound iron in plasma from hemochromatosis patients: effect of phlebotomy therapy
    • O.I. Aruoma A. Bomford J.J. Poison B. Halliewell Nontransferrin-bound iron in plasma from hemochromatosis patients: effect of phlebotomy therapy Blood 72 1988 1416 1419
    • (1988) Blood , vol.72 , pp. 1416-1419
    • Aruoma, O.I.1    Bomford, A.2    Poison, J.J.3    Halliewell, B.4
  • 69
    • 0026800818 scopus 로고
    • High stored iron levels are associated with excess risk of myocardial infarction in Eastern Finnish men
    • J.T. Salonen K. Nyyssonen H. Korpela J. Tuomilehto R. Seppanen R. Salonen High stored iron levels are associated with excess risk of myocardial infarction in Eastern Finnish men Circulation 86 1992 803 811
    • (1992) Circulation , vol.86 , pp. 803-811
    • Salonen, J.T.1    Nyyssonen, K.2    Korpela, H.3    Tuomilehto, J.4    Seppanen, R.5    Salonen, R.6
  • 72
    • 16144365807 scopus 로고    scopus 로고
    • Birthweight as a risk factor for breast cancer
    • K.B. Michels D. Trichopoulos J.M. Robins Birthweight as a risk factor for breast cancer Lancet 348 1996 1542 1546
    • (1996) Lancet , vol.348 , pp. 1542-1546
    • Michels, K.B.1    Trichopoulos, D.2    Robins, J.M.3
  • 73
  • 74
    • 0030607605 scopus 로고    scopus 로고
    • Birthweight, body-mass index in middle age, and incident coronary heart disease
    • S. Frankel P. Elwood P. Sweetnam J. Yarnell G.D. Smith Birthweight, body-mass index in middle age, and incident coronary heart disease Lancet 348 1996 1478 1480
    • (1996) Lancet , vol.348 , pp. 1478-1480
    • Frankel, S.1    Elwood, P.2    Sweetnam, P.3    Yarnell, J.4    Smith, G.D.5
  • 75
    • 0025297450 scopus 로고
    • Fetal and placental size and risk of hypertension in adult life
    • D.J.P. Barker A.R. Bull C. Osmond S.J. Simmonds Fetal and placental size and risk of hypertension in adult life BMJ 301 1990 259 262
    • (1990) BMJ , vol.301 , pp. 259-262
    • Barker, D.J.P.1    Bull, A.R.2    Osmond, C.3    Simmonds, S.J.4
  • 78
    • 0029865150 scopus 로고    scopus 로고
    • 4-Hydroxylation of estrogens as marker of human mammary tumors
    • J.G. Liehr M.J. Ricci 4-Hydroxylation of estrogens as marker of human mammary tumors Proc Natl Acad Sci 93 1996 3294 3296
    • (1996) , pp. 3294-3296
    • Liehr, J.G.1    Ricci, M.J.2
  • 79
    • 0025313058 scopus 로고
    • Free radical generation by redox cycling of estrogens
    • J.G. Liehr D. Roy Free radical generation by redox cycling of estrogens Free Rad Biol Med 8 1990 415 423
    • (1990) Free Rad Biol Med , vol.8 , pp. 415-423
    • Liehr, J.G.1    Roy, D.2
  • 80
    • 0030802151 scopus 로고    scopus 로고
    • A maternal diet high in n-6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring
    • L. Hilakivi-Clarke R. Clarke I. Onojafe M. Raygada E. Cho M. Lippman A maternal diet high in n-6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring Proc Nat Acad Sci 94 1997 9372 9377
    • (1997) , pp. 9372-9377
    • Hilakivi-Clarke, L.1    Clarke, R.2    Onojafe, I.3    Raygada, M.4    Cho, E.5    Lippman, M.6
  • 81
    • 0028909019 scopus 로고
    • DNA damage and repair in telomeres: relation to aging
    • P.A. Kruk N.J. Rampino A. Bohr DNA damage and repair in telomeres: relation to aging Proc Natl Acad Sci 92 1995 258 262
    • (1995) , pp. 258-262
    • Kruk, P.A.1    Rampino, N.J.2    Bohr, A.3
  • 82
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • C.B. Harley A.B. Futcher C.W. Greider Telomeres shorten during ageing of human fibroblasts Nature 345 1990 458 460
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 84
    • 0006341355 scopus 로고
    • Intrinsic aging of postmitotic cells
    • R.R. Kohn Intrinsic aging of postmitotic cells R.J. Blandau Aging Gametes 1975 S Krager New York 1 18
    • (1975) , pp. 1-18
    • Kohn, R.R.1
  • 85
    • 0015844590 scopus 로고
    • A theory of marginotomy: the incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
    • A.M. Olovnikov A theory of marginotomy: the incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon J Theor Biol 41 1973 181 190
    • (1973) J Theor Biol , vol.41 , pp. 181-190
    • Olovnikov, A.M.1
  • 86
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • A.G. Bodnar M. Ouellette M. Frolkis Extension of life-span by introduction of telomerase into normal human cells Science 279 1998 349 352
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ouellette, M.2    Frolkis, M.3
  • 87
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • N.W. Kim M.A. Piatyszek K.R. Prowse Specific association of human telomerase activity with immortal cells and cancer Science 266 1994 2011 2015
    • (1994) Science , vol.266 , pp. 2011-2015
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3
  • 88
    • 0029127226 scopus 로고
    • Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?
    • T. von Zglinicki G. Saretzki W. Docke C. Lotze Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exper Cell Res 220 1995 186 193
    • (1995) Exper Cell Res , vol.220 , pp. 186-193
    • von Zglinicki, T.1    Saretzki, G.2    Docke, W.3    Lotze, C.4
  • 89
    • 0032054781 scopus 로고    scopus 로고
    • Accelerated telomere shortening in fibroblast after extended periods of confluency
    • N. Sitte G. Saretzki T. von Zglinicki Accelerated telomere shortening in fibroblast after extended periods of confluency Free Rad Bio Med 24 1998 in press
    • (1998) Free Rad Bio Med , vol.24
    • Sitte, N.1    Saretzki, G.2    von Zglinicki, T.3
  • 90
    • 0003433979 scopus 로고
    • Current population reports. Special studies. Sixty-five plus in America
    • Bureau of the Census Current population reports. Special studies. Sixty-five plus in America 1993 Government Printing Office Washington, DC (P23-1k78RV.)
    • (1993)
    • Bureau of the Census1
  • 91
    • 0028237230 scopus 로고
    • The oldest old
    • E.W. Campion The oldest old N Engl J Med 330 1994 1819 1820
    • (1994) N Engl J Med , vol.330 , pp. 1819-1820
    • Campion, E.W.1
  • 92
    • 0030909364 scopus 로고    scopus 로고
    • Chronic disability trends in elderly United States populations: 1982–1994
    • K.G. Manton L. Corder E. Stallard Chronic disability trends in elderly United States populations: 1982–1994 Proc Natl Acad Sci 94 1997 2593 2598
    • (1997) , pp. 2593-2598
    • Manton, K.G.1    Corder, L.2    Stallard, E.3
  • 93
    • 0029910163 scopus 로고    scopus 로고
    • Declining cancer mortality in the United States
    • P. Cole B. Rodu Declining cancer mortality in the United States Cancer 78 1996 2045 2048
    • (1996) Cancer , vol.78 , pp. 2045-2048
    • Cole, P.1    Rodu, B.2
  • 94
  • 95
    • 0002694697 scopus 로고    scopus 로고
    • Births and deaths: United States, 1996
    • S.J. Ventura K.D. Peters J.A. Martin J.D. Maurer Births and deaths: United States, 1996 Monthly vital statistics report, 46 1997 National Center for Health Statistics Hyattsville, Maryland (No.1,Suppl.2)
    • (1997)
    • Ventura, S.J.1    Peters, K.D.2    Martin, J.A.3    Maurer, J.D.4
  • 97
    • 0030013268 scopus 로고    scopus 로고
    • Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly
    • K.G. Losonczy T.B. Harris R.J. Havlik Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly Am J Clin Nutr 64 1996 190 196
    • (1996) Am J Clin Nutr , vol.64 , pp. 190-196
    • Losonczy, K.G.1    Harris, T.B.2    Havlik, R.J.3
  • 98
    • 0008129094 scopus 로고
    • Counterviewpoint: Vitamin C and mortality
    • J.E. Enstrom Counterviewpoint: Vitamin C and mortality Nutr Today 28 1993 39 42 (May–June)
    • (1993) Nutr Today , vol.28 , pp. 39-42
    • Enstrom, J.E.1
  • 99
    • 0026858318 scopus 로고
    • Vitamin C and reduced mortality
    • G. Block Vitamin C and reduced mortality Epidemiol 3 1992 189 191
    • (1992) Epidemiol , vol.3 , pp. 189-191
    • Block, G.1
  • 100
    • 0025614852 scopus 로고
    • Use of vitamin and mineral supplements: demographics and amounts of nutrients consumed
    • A.F. Subar G. Block Use of vitamin and mineral supplements: demographics and amounts of nutrients consumed Am J Epidemiol 132 1990 1091 1101
    • (1990) Am J Epidemiol , vol.132 , pp. 1091-1101
    • Subar, A.F.1    Block, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.