p53 and bcl-2 protein expression in rectosigmoid adenomas

American Journal of Gastroenterology

Volumn 93, Issue 7, 1998, Pages 1136-1140

  Papatheodoridis, George V ^b   Kapranos, Nikiforos ^b   Tzouvala, Maria ^b   Triantafyllou, Konstantinos ^b   Elemenoglou, Ioannis ^b   Karamanolis, Demetrios G ^a  

^a TZANEIO GENERAL HOSPITAL OF PIRAEUS   (Greece)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; PROTEIN P53;

ADULT; AGED; ARTICLE; COLON ADENOMA; COLONOSCOPY; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOMA; ADENOMA, VILLOUS; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; COLONIC NEOPLASMS; COLONOSCOPY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM STAGING; ODDS RATIO; PROTO-ONCOGENE PROTEINS C-BCL-2; RECTAL NEOPLASMS; RISK FACTORS; SIGMOID NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032455391     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1572-0241.1998.00344.x     Document Type: Article

References (16)

1. 1. Zarchy TM, Ershoff D. Do characteristics of adenomas on flexible sigmoidoscopy predict advanced lesions on baseline colonoscopy? Gastroenterology 1994;106:1501-1.
2. 2. Papatheodoridis GV, Triantafyllou K, Tzouvala M, et al. Characteristics of rectosigmoid adenomas as predictors of synchronous advanced proximal colon neoplasms. Am J Gastroenterol 1996;91: 1809-13.
3. 3. Read TE, Read JD, Butterly LF. Importance of adenomas 5 mm or less in diameter that are detected by sigmoidoscopy. N Engl J Med 1997; 336:8-12.
4. 4. Winawer SJ, Fletcher RH, Miller L, et al. Colorectal cancer screening: Clinical guidelines and rationale. Gastroenterology 1997;112:594-642.
5. 5. Lane DP. p53, Guardian of the genome. Nature 1992;358:15-6.
6. 6. Harris CC, Hollstein M. Clinical implications of the p53 tumor-suppressor gene. N Engl J Med 1993;329:1318-27.
7. 7. Scott N, Quirke P. Molecular biology of colorectal cancer. Gut 1993; 34:289-92.
8. 8. Morrin M, Kelly M, Barrett N, et al. Mutations of Ki-ras and p53 genes in colorectal cancer and their prognostic significance. Gut 1994;35: 1627-31.
9. 9. Sinicrope FA, Ruan SB, Cleary KR, et al. bcl-2 And p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res 1995;55:237-41.
10. 10. Levi E, Stryker SJ, Rao MS. p53 Protein overexpression in colorectal tumors from patients with familial adenomatous polyposis: Is it an early or late event? Am J Gastroenterol 1996;91:11-4.
11. 11. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal development. N Engl J Med 1988;319:525-32.
12. 12. Williams GT. Programmed cell death: Apoptosis and oncogenesis. Cell 1991;65:1097-8.
13. 13. Hockenbery DM, Nunez G, Milliman C, et al. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;348:334-6.
14. 14. Reed JC. Bcl-2 and the regulation of programmed cell death. J Cell Biol 1993;124:1-6.
15. 15. Bronner MP, Culin C, Reed JC, et al. The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. Am J Pathol 1995; 146:20-6.
16. 16. Karamanolis DG. Colorectal cancer screening and the need of targeting colonoscopy. Gastroenterol Intern 1996;9:126-32.