Depletion of protein kinase C-α by antisense oligonucleotides alters beta-adrenergic function and reverses the phorbol ester-induced reduction of isoproterenol-induced adenosine 3'-5'-cyclic monophosphate accumulation in murine Swiss 3T3 fibroblasts

Journal of Pharmacology and Experimental Therapeutics

Volumn 287, Issue 1, 1998, Pages 425-434

  Levesque, Luc ^a,b   Crooke, Stanley T ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ADENYLATE CYCLASE; ANTISENSE OLIGONUCLEOTIDE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLERA TOXIN; CYCLIC AMP; ISOPRENALINE; PHORBOL ESTER; PROTEIN KINASE C;

ADRENERGIC SYSTEM; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG ACCUMULATION; ENZYME ACTIVATION; ENZYME INHIBITION; FIBROBLAST CULTURE; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR INTRINSIC ACTIVITY; REGULATORY MECHANISM; SEQUENCE ANALYSIS;

3T3 CELLS; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CHOLERA TOXIN; CYCLIC AMP; FORSKOLIN; INDOLES; ISOENZYMES; ISOPROTERENOL; MALEIMIDES; MICE; OLIGONUCLEOTIDES, ANTISENSE; PHORBOL 12,13-DIBUTYRATE; PROTEIN KINASE C; RECEPTORS, ADRENERGIC, BETA; RNA, MESSENGER;

EID: 0032455112     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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