Distinctions in lymphocyte responses to IL-2 and IL-15 reflect differential ligand binding interactions with the IL-2Rβ chain and suggest differential roles for the IL-2Rα and IL-15Rα subunits

Cytokine

Volumn 10, Issue 12, 1998, Pages 920-930

  De Jong, J L O ^a   Farner, N L ^a   Sondel, Paul M ^a,b,c  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c University of Wisconsin Health   (United States)

Author keywords

Cytokine receptors; Interleukin 15; Interleukin 2; Lymphocytes

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MONOCLONAL ANTIBODY; PHYTOHEMAGGLUTININ;

ARTICLE; BINDING AFFINITY; BLAST CELL; CASE REPORT; HUMAN; HUMAN CELL; LIGAND BINDING; LYMPHOCYTE; PRIORITY JOURNAL;

EID: 0032454722     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1998.0377     Document Type: Article

References (25)

1. 1. Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, Fung V, Beers C, Richardson J, Schoenborn MA, Ahdieh M, Johnson L, Alderson MR, Watson JD, Andersen DM, Giri JG (1994) Clonin of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 264:965-968.
2. 2. Carson WE, Giri JG, Lindemann MJ, Linett ML, Ahdieh M, Paxton R, Anderson D, Eisenman J, Grabstein K, Caligiuri MA (1994) Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 180:1395-1403.
3. 3. Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH (1995) IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol 154:483-490.
4. 4. Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, Kumaki S, Namen A, Park LS, Cosman D, Anderson D (1994) Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine, IL-15. EMBO J 13:2822-2830.
5. 5. Robb RJ, Greene WC, Rusk CM (1984) Low and high affinity cellular receptors for Interleukin 2: Implications for the level of Tac antigen. J Exp Med 160:1126-1146.
6. 6. Smith KA (1989) The interleukin-2 receptor. Annu Rev Cell Biol 5:397-425.
7. 7. Waldmann TA (1991) The interleuikin-2 receptor. J Biol Chem 266:2681-2684.
8. 8. Taniguchi T, Minami Y (1993) The IL-2/IL-2 receptor system: a current overview. Cell 73:5-8.
9. 9. Anderson DM, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A, Giri J, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Shapiro DN, Morris SW, Park LS, Cosman D (1995) Functional characterization of the human interleukin-15 receptor α chain and close linkage of the IL15RA and IL2RA genes. J Biol Chem 270:29862-29869.
10. 10. Johnston JA, Bacon CM, Finbloom DS, Rees RC, Kaplan D, Shibuya K, Ortaldo J, Gupta S, Chen YQ, Giri JG, O'Shea JJ (1995) Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc Natl Acad Sci USA 92:8705-8709.
11. 11. Lin J-X, Migone T-S, Tsang M, Friedmann M, Weatherbee JA, Zhou L, Yamauchi A, Bloom ET, Mietz J, John S, Leonard WJ (1995) The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13 and IL-15. Immunity 2:331-339.
12. 12. Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM (1995) Identification and cloning of a novel IL-15 binding protein that is structurally related to the a chain of the IL-2 receptor. EMBO J 14:3654-3663.
13. 13. Kitamura T, Tange T, Terasawa T, Chiba S, Kuwaki T, Miyagawa K, Piao YF, Miyazono K, Urabe A, Takaku F (1989) Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J Cell Phys 140:323-334.
14. c detection and function in YT lymphoid cells and in the GM-CSF responsive human myeloid cell line, Tf-1. Blood 86:4568-4578.
15. 15. Weil-Hillman G, Schell K, Segal DM, Hank JA, Sosman JA, Sondel PM (1991) Activation of human T cells obtained pre- and post-interleukin-2 (IL-2) therapy by anti-CD3 monoclonal antibody plus IL-2: Implications for combined in vivo treatment. J Immunother 10:267-277.
16. c receptor-ligand complex. J Immunol 156:1339-1348.
17. 17. Sauvé K, Nachman M, Spence C, Bailon P, Campbell E, Tsien W-H, Kondas JA, Hakimi J, Ju G (1991) Localization in human interleukin 2 of the binding site to the a chain (p55) of the interleukin 2 receptor. Proc Natl Acad Sci USA 88:4636-4640.
18. 18. Grant A, Roessler E, Ju G, Tsudo M, Sugamura K, Waldmann T (1992) The interleukin 2 receptor (IL-2R): The IL-2Rα subunit alters the function of the IL-2Rβ subunit to enhance IL-2 binding and signaling by mechanisms that do not require binding of IL-2 to the IL-2Rα subunit. Proc Natl Acad Sci USA 89:2165-2169.
19. 19. Roessler E, Grant A, Ju G, Tsudo M, Sugamura K, Waldmann TA (1994) Cooperative interactions between the interleukin 2 receptor α and β chains alter the interleukin 2-binding affinity of the receptor subunits. Proc Natl Acad Sci USA 91:3344-3347.
20. 20. Voss SD, Sondel PM, Robb RJ (1992) Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: Association of the p64 IL-2Rγ chain with the IL-2Rβ chain in functional intermediate affinity IL-2R. J Exp Med 176:531-541.
21. 21. Robb RJ, Rusk CM, Neeper MP (1988) Structure-function relationships for the interleukin-2 receptor: Location of ligand and antibody binding sites on the Tac receptor chain by mutational analysis. Proc Natl Acad Sci USA 85:5654-5658.
22. 22. Tsudo M, Kitamura F, Miyasaka M (1989) Characterization of the interleukin 2 receptor β chain using three distinct monoclonal antibodies. Proc Natl Acad Sci USA 86:1982-1986.
23. 23. Hakimi J, Ha VC, Lin P, Campbell E, Gately MK, Tsudo M, Payne PW, Waldmann TA, Grant AJ, Tsien WH, Schneider WP (1993) Humanized Mikβ1, a humanized antibody to the IL-2 receptor β-chain that acts synergistically with humanized anti-TAC. J Immunol 151:1075-1081.
24. 24. de Jong JLO, Farner JL, Javorsky BR, Lindstrom MJ, Hank JA, Sondel PM (1998) Differential quantitative effects of IL-2 and IL-15 on cytotoxic activity and proliferation by lymphocytes from patients receiving in vivo IL-2 therapy. Clin Cancer Res. 5:1287-1296.
25. 25. Chae DW, Nosaka Y, Strom TB, Maslinski W (1996) Distribution of IL-15 receptor alpha-chains on human peripheral blood mononuclear cells and effect of immunosuppressive drugs on receptor expression. J Immunol 157:2813-2819.