Chronic ethanol administration alters hepatic rates of glycerol phosphorylation and glycerol 3-phosphate oxidation: A dynamic in vivo 31P magnetic resonance spectroscopy study

Biochemistry and Cell Biology

Volumn 76, Issue 2-3, 1998, Pages 542-552

  Brauer, Manfred ^a   Lu, Wuhua ^a   Ling, Mingfu ^a,b  

^a UNIVERSITY OF GUELPH   (Canada)

^b Spectral Diagnostics Inc   (Canada)

Author keywords

31P magnetic resonance spectroscopy; Ethanol; Glycerol; Liver; Metabolism

Indexed keywords

ALCOHOL; GLYCEROL; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; GLYCEROL KINASE; GLYCEROPHOSPHATE; LACTIC ACID; PERCHLORIC ACID; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; HYPEROXIA; IN VIVO STUDY; LIVER METABOLISM; MALE; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PHOSPHORYLATION; RAT;

ANIMALIA;

EID: 0032454614     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o98-047     Document Type: Article

References (34)

1. Adams, P.R., and Harrison, R. 1974. Dehydrogenation of a phosphonate substrate analogue by glycerol 3-phosphate dehydrogenase. Biochem. J. 141: 729-732.
2. Arteel, G.E., Iimuro, Y., Yin, M., Raleigh, J., and Thurman, R.G. 1997. Chronic enteral ethanol treatment causes hypoxia in rat liver tissue in vivo. Hepatology, 25: 920-926.
3. 31P-n.m.r. study. Biochem. J. 291: 915-919.
4. 13C-NMR study of liver regeneration in rats. Physiol. Chem. Phys. Med. NMR, 17: 261-270.
5. 31P NMR spectroscopy. Magn. Reson. Med. 20: 100-112.
6. 31P magnetic resonance spectroscopy study. J. Stud. Alcohol, 58: 119-129.
7. Brdiczka, K. 1990. Interaction of mitochondrial porin with cytosolic proteins. Experientia (Basel), 46: 161-167.
8. Canioni, P., Alfer, J.R., and Shulman, R.G. 1983. Natural abundance carbon-13 nuclear magnetic resonance spectroscopy of liver and adipose tissue of the living rat. Biochemistry, 22: 4974-4980.
9. Certaines, J.D., Bovee, W.M., and Podo, F. 1992. Magnetic resonance spectroscopy in biology and medicine. Pergamon Press, Oxford, U.K. pp. 345-387.
10. Cox, I.J. 1996. Development and applications of in vivo clinical magnetic resonance spectroscopy. Prog. Biophys. Mol. Biol. 65: 45-81.
11. 31P NMR. Biochim. Biophys. Acta, 885: 12-22.
12. Desmoulin, F., Canioni, P., Crotte, C., Gérolami, A., and Cozzone, P.J. 1987. Hepatic metabolism during acute ethanol administration: a phosphorous-31 nuclear magnetic resonance study on the perfused rat liver under normoxic or hypoxic conditions. Hepatology, 7: 315-323.
13. Grunnet, N., and Lundquist, F. 1967. Kinetics of glycerol kinases from mammalian liver and Candida mycoderma. Eur. J. Biochem. 3: 78-84.
14. Israel Y., and Orrego, H. 1987. Hypermetabolic state, hepatocyte expansion and liver blood flow: an interactive triad in alcoholic liver injury. Ann. N.Y. Acad. Sci. 492: 303-324.
15. LaBaume, L.B., Merrill, D.K., and Guynn, R.W. 1987. Effects of acute ethanol on serine biosynthesis in liver. Arch. Biochem. Biophys. 250: 569-577.
16. Lieber, C.S. 1997. Ethanol metabolism, cirrhosis and alcoholism. Clin. Chim. Acta, 257: 59-84.
17. Lin, E.C.C. 1977. Glycerol utilization and its regulation in mammals. Annu. Rev. Biochem. 46: 765-795.
18. 31P NMR spectroscopic studies of rat liver subjected to chronic ethanol administration. Biochim. Biophys. Acta, 1051: 151-158.
19. 1H NMR analyses of methyl group-containing metabolites in rat liver extracts: effects of starvation, anoxia, acute glycerol and carbon tetrachloride treatment and chronic ethanol administration on hepatic metabolism. Physiol. Chem. Phys. Med. NMR, 23: 229-238.
20. 1H chemical shift selective magnetic resonance imaging and localized spectroscopic methods. Magn. Reson. Imaging, 10: 663-677.
21. Otto, J., Raggi, A., Machleidk, W., and Bucher, T. 1972. Isolierung und Kristallisation der Glycerin-3-phosphat-Dehydrogenase aus Kaninchenleber. Hoppe-Seyler's Z. Physiol. Chem. 353: 332-344.
22. Robinson, J., and Newsholme, E.A. 1969. The effects of dietary conditions and glycerol concentration on glycerol uptake by rat liver and kidney-cortex slices. Biochem. J. 112: 449-453.
23. Savolainen, M.J., Baraona, E., Pikkarainen, P., and Lieber, C.S. 1981. Hepatic triacylglycerol synthesizing activity during progression of alcoholic liver injury in the baboon. J. Lipid Res. 25: 813-820.
24. Seitz, H.J., Porsche, E., and Tarnowski, W. 1976. Glycerolkinase: a regulatory enzyme of gluconeogenesis? Acta Biol. Med. Ger. 35: 141-154.
25. Sestoft, L., and Fleron, P. 1975. Kinetics of glycerol uptake by the perfused rat liver. Biochim. Biophys. Acta, 375: 462-471.
26. Sies, H. 1982. Nicotinamide nucleotide compartmentation. In Metabolic compartmentation. Edited by H. Sies. Academic Press, London, pp. 205-231.
27. 31P magnetic resonance spectroscopy and electron microscopy of the cirrhotic liver. Liver, 17: 198-209.
28. Thieden, H.I.D. 1969. The influence of ethanol on glycerol metabolism in liver slice from fed and fasted rats. Acta Chem. Scand. 23: 237-243.
29. Thorner, J.W., and Paulus, H. 1973. Glycerol and glycerate kinases. In The enzymes. Vol. VIII. Edited by P.D. Boyer. Academic Press, New York. pp. 487-509.
30. Vind, C., Hunding, A., and Gunnet, N. 1975. Pathways of reducing agents in hepatocytes from rats. Biochim. Biophys. Acta, 375: 462-471.
31. Vind, C., Hunding, A., and Grunnet, N. 1987. Pathways of reducing equivalents in hepatocytes from rats. Biochem. J. 243: 625-630.
32. Williamson, D.H., Velosso, D., Ellington, E.V., et al. 1969. Changes in the concentrations of hepatic metabolites on administration of dihydroxyacetone or glycerol to starved rats and their relationship to the control of ketogenesis. Biochem. J. 114: 575-584.
33. Woods, H. F., and Krebs, H.A. 1973. Effect of glycerol and dihydroxyacetone on hepatic adenine nucleotides. Biochem. J. 132: 55-60.
34. Zanoboni, A., Schwarz, D., and Zanoboni-Muciaccia, W. 1976. Stimulation of insulin secretion in main by oral glycerol administration. Metab. Clin. Exp. 25: 41-45.