Use of a pharmacokinetic/pharmacodynamic model to design an optimal dose input profile

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 26, Issue 4, 1998, Pages 471-492

  Park, Kyungsoo ^a,b   Verotta, Davide ^a,c   Gupta, Suneel K ^d   Sheiner, Lewis B ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ALZA CORPORATION   (United States)

Author keywords

Drug effect; Nonparametric distribution; Optimal input profile; Pharmacodynamic model; Placebo effect; Random effect; Tolerance

Indexed keywords

ANALGESIC AGENT;

CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE CALCULATION; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM; DRUG MECHANISM; DRUG TOLERANCE; HUMAN; MATHEMATICAL ANALYSIS; MODEL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW;

EID: 0032454220     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021068202606     Document Type: Review

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