AZT trials to reduce perinatal HIV transmission: A debate about science, ethics and resources

Reproductive Health Matters

Volumn 6, Issue 11, 1998, Pages 129-130

  McIntyre, James ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; PLACEBO; RETINOL; ZIDOVUDINE;

ARTICLE; BREAST FEEDING; CLINICAL TRIAL; DELIVERY; DEVELOPING COUNTRY; DISEASE TRANSMISSION; ETHIOPIA; HEALTH CARE POLICY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERVIEW; INTRAVENOUS DRUG ADMINISTRATION; MEDICAL ETHICS; MEDICAL RESEARCH; META ANALYSIS; ORAL DRUG ADMINISTRATION; PERINATAL INFECTION; PREGNANCY; PRIORITY JOURNAL; RESOURCE ALLOCATION; SCREENING; SOUTH AFRICA; THAILAND;

EID: 0032454202     PISSN: 09688080     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-8080(98)90090-8     Document Type: Article

References (6)

1. In that study, women were given oral zidovudine (AZT) five times daily starting in the second trimester of pregnancy through to delivery, and intravenous AZT during labour; AZT syrup was then given to the baby for six weeks. The study showed a two-thirds reduction in transmission rates, and the regimen has become the accepted standard of care in many developed countries. See: Connor EM, Sperling RS, Geiber R et al, 1994. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. NEJM. 331:1173-80.
2. Lurie P, Wolfe SM, 1997. Unethical trials of interventions to reduce perinatal transmission of the human immunodeficiency virus in developing countries. NEJM. 337:853-56.
3. Angell M, 1997. The ethics of clinical research in the third world. NEJM. 337:847-49.
4. Two resign after Journal's AIDS story. Associated Press. 15 October 1997.
5. Varmus H, Satcher D, 1997. Ethical complexities of conducting research in developing countries. NEJM. 337(14):1003-05.
6. Jones JH, 1981. Bad Blood: The Tuskegee Syphilis Experiment. Free Press, New York.