메뉴 건너뛰기




Volumn 14, Issue 4, 1997, Pages 177-184

Derivatives of leflunomide's active metabolite a77-1726, the malononitrilamides (MNAs), prevent the development of experimental arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRHEUMATIC AGENT; COLLAGEN TYPE 2; DRUG METABOLITE; LEFLUNOMIDE; RHEUMATOID FACTOR;

EID: 0032453856     PISSN: 02559625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (5)

References (24)
  • 1
    • 0001602537 scopus 로고    scopus 로고
    • Leflunomide plus methotrexate in refractory rheumatoid arthritis: A pilot study
    • Weinblatt M., Kremer J., Coblyn J., et al. Leflunomide plus methotrexate in refractory rheumatoid arthritis: a pilot study. Arth. Rheum., 40, 974, 1997.
    • (1997) Arth. Rheum. , vol.40 , pp. 974
    • Weinblatt, M.1    Kremer, J.2    Coblyn, J.3
  • 2
    • 0031838192 scopus 로고    scopus 로고
    • Clinical experience with leflunomide in rheumaotid arthritis
    • Rozman B. Clinical experience with leflunomide in rheumaotid arthritis. J. Rheumatol., 25, 27,1998.
    • (1998) J. Rheumatol. , vol.25 , pp. 27
    • Rozman, B.1
  • 3
    • 0029127555 scopus 로고
    • Dihydroorotate dehydrogenase is a high affinity binding protein for A77-1726 and mediator of a range of biological effects of the immunomodulatory compound
    • Williamson R.A., Yea C.M., Robson P.A., et al. Dihydroorotate dehydrogenase is a high affinity binding protein for A77-1726 and mediator of a range of biological effects of the immunomodulatory compound. J. Biol. Chem., 270, 22467, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22467
    • Williamson, R.A.1    Yea, C.M.2    Robson, P.A.3
  • 4
    • 10544236523 scopus 로고    scopus 로고
    • Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3-methyl-4-(tri!/uoromethyl)phenyl] propenamide and related compounds
    • Kuo E.A., Hambleton P.T., Kay O.P., et al. Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3-methyl-4-(tri!/uoromethyl)phenyl] propenamide and related compounds. J. Med. Chem., 39, 4608, 1996.
    • (1996) J. Med. Chem. , vol.39 , pp. 4608
    • Kuo, E.A.1    Hambleton, P.T.2    Kay, O.P.3
  • 7
  • 9
    • 0030987746 scopus 로고    scopus 로고
    • Leflunomide and malononitrilamides
    • Suva H.T., Morris R.E. Leflunomide and malononitrilamides. Am. J. Med. Sci., 313, 289, 1997.
    • (1997) Am. J. Med. Sci. , vol.313 , pp. 289
    • Suva, H.T.1    Morris, R.E.2
  • 10
    • 0031804660 scopus 로고    scopus 로고
    • Comparative effects of malononitrilamide analogs of leflunomide on whole blood lymphocyte stimulation in humans, rhesus macaques, cats, dogs, and rats
    • Gregory C.R., Suva H.T. Patz J.D., Morris R.E. Comparative effects of malononitrilamide analogs of leflunomide on whole blood lymphocyte stimulation in humans, rhesus macaques, cats, dogs, and rats. Transplant. Proc., 30, 1047, 1998.
    • (1998) Transplant. Proc. , vol.30 , pp. 1047
    • Gregory, C.R.1    Suva, H.T.2    Patz, J.D.3    Morris, R.E.4
  • 11
    • 0013379778 scopus 로고    scopus 로고
    • A molecular mechanism for the direct antiproliferative effect of malononitrilamides (MNAs) on vascular smooth muscle cells
    • Czech J., Schwab W., Schorlemmer H.U. A molecular mechanism for the direct antiproliferative effect of malononitrilamides (MNAs) on vascular smooth muscle cells. Transplantation, 65, S39, 1998.
    • (1998) Transplantation , vol.65
    • Czech, J.1    Schwab, W.2    Schorlemmer, H.U.3
  • 12
    • 3643092923 scopus 로고    scopus 로고
    • Flow cytometric (FCM) analysis of the molecular mechanisms of immunosuppressive action of the active metabolite of leflunomide and its malononitrilamide (MNA) analogs in a novel whole blood assay
    • Slauson S., Suva H, Sherwood S., Morris R.E. Flow cytometric (FCM) analysis of the molecular mechanisms of immunosuppressive action of the active metabolite of leflunomide and its malononitrilamide (MNA) analogs in a novel whole blood assay. Transplantation, 65, S134,1998.
    • (1998) Transplantation , vol.65
    • Slauson, S.1    Suva, H.2    Sherwood, S.3    Morris, R.E.4
  • 13
    • 0031609664 scopus 로고    scopus 로고
    • Regulation of alloreactivity in the popliteal lymph node assay by the new immunosuppressants:malononitrilamides
    • Schorlemmer H.U., Ruuth E., Kurrle R. Regulation of alloreactivity in the popliteal lymph node assay by the new immunosuppressants:malononitrilamides. Transpl. Int., 11, S448, 1998.
    • (1998) Transpl. Int. , vol.11
    • Schorlemmer, H.U.1    Ruuth, E.2    Kurrle, R.3
  • 14
    • 0031832590 scopus 로고    scopus 로고
    • Inhibition of alloreactivity in the popliteal lymph node assay by malononitrilamides
    • Schorlemmer H.U., Bartlett R.R., Kurrle R. Inhibition of alloreactivity in the popliteal lymph node assay by malononitrilamides. Transplant. Proc., 30, 968,1998.
    • (1998) Transplant. Proc. , vol.30 , pp. 968
    • Schorlemmer, H.U.1    Bartlett, R.R.2    Kurrle, R.3
  • 15
    • 0002506544 scopus 로고    scopus 로고
    • Inhibition of dihydroorotate dehydrogenase (DHODH) is the molecular mechanism of immunosuppression by the malononitrilamides (MNAs) in vivo
    • Suva H.T., Slauson S., Shorthouse R., Lôffler M., Morris R.E. Inhibition of dihydroorotate dehydrogenase (DHODH) is the molecular mechanism of immunosuppression by the malononitrilamides (MNAs) in vivo. Transplantation, 65, S28, 1998.
    • (1998) Transplantation , vol.65
    • Suva, H.T.1    Slauson, S.2    Shorthouse, R.3    Lôffler, M.4    Morris, R.E.5
  • 16
    • 0031976727 scopus 로고    scopus 로고
    • Malononitrilamides: A new strategy of immunosuppression for a/to- And xenotransplantation
    • Schorlemmer H., Bartlett R., Kurrle R. Malononitrilamides: a new strategy of immunosuppression for a/to- and xenotransplantation. Transplant. Proc., 30, 884, 1998.
    • (1998) Transplant. Proc. , vol.30 , pp. 884
    • Schorlemmer, H.1    Bartlett, R.2    Kurrle, R.3
  • 17
    • 0030816569 scopus 로고    scopus 로고
    • Prevention of the development of murine systemic lupus erythematosus (SLE)-like diseases by the malononitrilamides MNA 279 and MNA 715
    • Schorlemmer H.U., Bartlett R.R. Prevention of the development of murine systemic lupus erythematosus (SLE)-like diseases by the malononitrilamides MNA 279 and MNA 715. Inflamm. Res., 46, S167, 1997.
    • (1997) Inflamm. Res. , vol.46
    • Schorlemmer, H.U.1    Bartlett, R.R.2
  • 18
    • 0031402564 scopus 로고    scopus 로고
    • Effects of the immunosuppressive malononitrilamides on rheumatoid and systemic lupus erythematosus (SLE)-like disease
    • Schorlemmer H.U., Bartlett R.R. Effects of the immunosuppressive malononitrilamides on rheumatoid and systemic lupus erythematosus (SLE)-like disease. Int. J. Immunotherapy, 13, 1, 1997.
    • (1997) Int. J. Immunotherapy , vol.13 , pp. 1
    • Schorlemmer, H.U.1    Bartlett, R.R.2
  • 19
    • 0031389857 scopus 로고    scopus 로고
    • Therapeutic activity of malononitrilamides (MNA 279 and MNA 715) on acute and chronic, relapsing, experimental allergic encephalomyelitis (EAE)
    • Schorlemmer H.U., Bartlett R.R. Therapeutic activity of malononitrilamides (MNA 279 and MNA 715) on acute and chronic, relapsing, experimental allergic encephalomyelitis (EAE). Drugs Exptl. Clin. Res., 23, 175, 1997.
    • (1997) Drugs Exptl. Clin. Res. , vol.23 , pp. 175
    • Schorlemmer, H.U.1    Bartlett, R.R.2
  • 20
    • 0030749015 scopus 로고    scopus 로고
    • Malononitrilamides (MNA 279 and MNA 715) have therapeutic activity in acute and chronic relapsing experimental allergic encephalomyelitis (EAE)
    • Schorlemmer H.U., Bartlett R.R. Malononitrilamides (MNA 279 and MNA 715) have therapeutic activity in acute and chronic relapsing experimental allergic encephalomyelitis (EAE). Inflamm. Res., 46, S163, 1997.
    • (1997) Inflamm. Res. , vol.46
    • Schorlemmer, H.U.1    Bartlett, R.R.2
  • 21
    • 0031350977 scopus 로고    scopus 로고
    • The new immunosuppressants, the malononitrilamides MNA 279 and MNA 715, inhibit various graft-vs.-host diseases (GvHD) in rodents
    • Schorlemmer H.U., Kurrle R., Bartlett R.R. The new immunosuppressants, the malononitrilamides MNA 279 and MNA 715, inhibit various graft-vs.-host diseases (GvHD) in rodents. Drugs Exptl. Clin. Res., 23, 167, 1997.
    • (1997) Drugs Exptl. Clin. Res. , vol.23 , pp. 167
    • Schorlemmer, H.U.1    Kurrle, R.2    Bartlett, R.R.3
  • 22
    • 0012287676 scopus 로고
    • The use of a standardized adjuvant arthritis assay to differentiate between antiinflammatory and immunosuppressive agents
    • Perper R., Alvarez B., Colombo C., Schröder H. The use of a standardized adjuvant arthritis assay to differentiate between antiinflammatory and immunosuppressive agents. Proc. Soc. Exp. Biol. Med., 137, 506, 1971.
    • (1971) Proc. Soc. Exp. Biol. Med. , vol.137 , pp. 506
    • Perper, R.1    Alvarez, B.2    Colombo, C.3    Schröder, H.4
  • 23
    • 0028792355 scopus 로고
    • Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis
    • Mladenovic V., Domljan I., Rozman B., et al. Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Arth. Rheum., 38, 1595, 1995.
    • (1995) Arth. Rheum. , vol.38 , pp. 1595
    • Mladenovic, V.1    Rozman, B.2
  • 24
    • 0343690132 scopus 로고    scopus 로고
    • Efficacy and safety of leflunomide versus placebo and sulfosalazine in rheumatoid arthritis: A double blind, randomized, pivotal, phase III trial
    • Smolen J.S., Kalden J.R., Rozman B., Scott D.L., Rosenburg R., Löw-Friedrich I. Efficacy and safety of leflunomide versus placebo and sulfosalazine in rheumatoid arthritis: a double blind, randomized, pivotal, phase III trial. Rheum. Eur., 27, 110, 1998.
    • (1998) Rheum. Eur. , vol.27 , pp. 110
    • Smolen, J.S.1    Kalden, J.R.2    Rozman, B.3    Scott, D.L.4    Rosenburg, R.5    Löw-Friedrich, I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.