Effects of 5-azacytidine and butyrate on differentiation and apoptosis of hepatic cancer cell lines

Annals of Surgery

Volumn 227, Issue 6, 1998, Pages 922-931

  Wang, Xiao Min ^a   Wang, Xiaofu ^a   Li, Jing ^a   Evers, B Mark ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; BUTYRIC ACID;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; LIVER CANCER; MICROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; RNA ANALYSIS;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; APOPTOSIS; AZACITIDINE; BLOTTING, WESTERN; BUTYRIC ACID; BUTYRIC ACIDS; CELL DIFFERENTIATION; DNA FRAGMENTATION; DNA PROBES; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; PRECIPITIN TESTS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 0032452623     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-199806000-00016     Document Type: Article

References (51)

1. Parker SL, Tong T, Bolden S. Wingo PA. Cancer statistics, 1997. CA Cancer J Clin 1997; 47:5-27.
2. Tsai S-L, Liaw Y-F. Etiology and pathogenesis of hepatocellular carcinoma. Dig Surg 1995; 12:7-15.
3. Di Bisceglie AM, Rustgi VK, Hoofnagle JH, et al. Hepatocellular carcinoma. Ann Intern Med 1988; 108:390-401.
4. Sherman M. Hepatocellular carcinoma. Gastroenterologist 1995; 3:55-66.
5. Muir C, et al. Cancer incidence in five continents. Lyon, France: IARC Sci. Publ.; 1987.
6. Nerenstone SR, Ihde DC, Friedman MA. Clinical trials in primary hepatocellular carcinoma: current status and future directions. Cancer Treat Rev 1988; 15:1-31.
7. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26:239-257.
8. Bellamy COC, Malcomson RDG, Harrison DJ, Wyllie AH. Cell death in health and disease: the biology and regulation of apoptosis. Sem Cancer Biol 1995; 6:3-16.
9. Hawkins CJ, Vaux DL. Analysis of the role of Bcl-2 in apoptosis. Immunol Rev 1994; 142:127-139.
10. Reed JC. Mechanisms of Bcl-2 family protein function and dysfunction in health and disease. Behring Inst Mitt 1996; 97:72-100.
11. Sentman CL, Shutter JR, Hochenbery D, et al. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 1991; 67:879-888.
12. Taylor SM, Jones PA. Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell 1979; 17:771-779.
13. Cedar H, Razin A. DNA methylation and development. Biochem Biophys Acad 1990; 1049:1-8.
14. Jones PA. Altering gene expression with 5-azacytidine. Cell 1985; 40:485-486.
15. Jones PA, Taylor SM. Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980; 20:85-93.
16. Iguchi-Ariga SM, Schaffner W. CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation. Gene Dev 1989; 3:612-619.
17. Pinto A, Zagonel V. 5-Aza-2′deoxycytidine (Decitabine) and 5-azacytidine in the treatment of acute myeloid leukemias and myelodysplastic syndromes: past, present and future trends. Leukemia 1993; 7:51-60.
18. Bhatia U, Traganos F, Darzynkiewicz Z. Induction of cell differentiation potentiates apoptosis triggered by prior exposure to DNA-damaging drugs. Cell Growth Differ 1995; 6:937-944.
19. Murakami T, Li X, Gong J, et al. Induction of apoptosis by 5-azacytidine: drug concentration-dependent differences in cell cycle specificity. Cancer Res 1995; 55:3093-3098.
20. Schwartz B, Lamprecht SA, Polak-Charcon S, et al. Induction of the differentiated phenotype in human colon cancer cell is associated with the attenuation of subcellular tyrosine phosphorylation. Oncol Res 1995; 7:277-287.
21. Zoref-Shani E, Lavie R, Bromberg Y, et al. Effects of differentiation-inducing agents on purine nucleotide metabolism in an ovarian cancer cell line. J Cancer Res Clin Oncol 1994; 120:717-722.
22. Aden DP, Fogel A, Plotkin S, et al. Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature 1979; 282:615-616.
23. Knowles BB, Howe CC, Aden DP. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 1980; 209:497-499.
24. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162:156-159.
25. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1987; 72:248-254.
26. Evers BM, Zhou Z, Celano P, Li J. The neurotensin gene is a down-stream target for ras activation. J Clin Invest 1995; 95:2822-2830.
27. Oberhammer F, Wilson JW, Dive C. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 1993; 12:3678-3684.
28. Taylor SM. 5-Aza-2′-deoxycytidine: cell differentiation and DNA methylation. Leukemia 1993; 7:3-8.
29. Kantarjian HM, Estey EH, Keating MA. New chemotherapeutic agents in acute myeloid leukemia. Leukemia 1996; 10:4-6
30. Kritz AD, Raptis G, Menendez-Botet C. Pilot study of 5-azacytidine (5-AZA) and carboplatin (CBDCA) in patients with relapsed/refractory leukemia. Am J Hematol 1996; 51:117-121.
31. He ZX, Rao H. The effect of 5-azacytidine (5-aza-CR) and its analogue on cell differentiation and DNA methylation of HL-60 cells. Sci Chin Series B Chem Life Sci Earth Sci 1993; 36:430-438.
32. 1 cell cycle arrest. J Lab Clin Med 1996; 128:335-360.
33. Satterwhite DJ, Moses HL. Mechanisms of transforming growth factor-beta-1-induced cell cycle arrest. Invasion Metast 1994-95; 14: 309-318.
34. Weller EM, Poot M, Hoehn H. Induction of replicative senescence by 5-azacytidine: fundamental cell kinetic differences between human diploid tibroblasts and NIH-3T3 cells. Cell Prolif 1993; 26:45-54.
35. Rivero JA, Adunyah SE. Sodium butyrate induces tyrosine phosphorylation and activation of MAP kinase (ERK-1) in human K562 cells. Biochem Biophys Res Com 1996; 224:796-801.
36. Schroy PC, Rustgi AK, Ikonomu E, et al. Growth and intestinal differentiation are independently regulated in HT29 colon cancer cells. J Cell Physiol 1994; 161:111-123.
37. Vincent-Fiquet O, Rogez JC, Boitte F, et al. Effects of arginine butyrate and tributyrylxylitol on cultured human carcinoma cells. Anticancer Res 1994; 14:1823-1828.
38. Waf/Cip1 in p53-independent manner. Biochem Biophys Res Com 1997; 237:457-460.
39. Hague A, Elder DJ, Hicks DJ, Paraskeva C. Apoptosis in colorectal tumor cell: induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate. Intl J Cancer 1995; 60:400-406.
40. Zimra Y, Wasserman L, Maron L, et al. Butyric acid and pivaloy-loxymethyl butyrate, AN-9, a novel butyric acid derivative, induce apoptosis in HL-60 cells. J Cancer Res Clin Oncol 1997; 123:152-160.
41. Mandal M, Wu X, Kumar R. Bcl-2 deregulation leads to inhibition of sodium butyrate-induced apoptosis in human colorectal carcinoma cells. Carcinogenesis 1997; 18:229-232.
42. McBain JA, Eastman A, Nobel CS, Mueller GC. Apoptotic death in adenocarcinoma cell lines by butyrate and other histone deacetylase inhibitors. Biochem Pharmacol 1977; 53:1357-1368.
43. Chang ST, Yung BY. Potentiation of sodium butyrate-induced apoptosis by vanadate in human promyelocytic leukemia cell line HL-60. Biochem Biophys Res Commun 1996; 221:594-601.
44. Thomas GL, Henley A, Rowland TC, et al. Enhanced apoptosis is transformed human lung fibroblasts after exposure to sodium butyrate. In Vitro Cell Dev Biol Animal 1996; 32:505-513.
45. Mandal M, Kumar R. Bcl-2 expression regulates sodium butyrate-induced apoptosis in human MCF-7 breast cancer cells. Cell Growth Differ 1996; 7:311-318.
46. Conway RM, Madigan MC, Penfold PL, Billson FA. Induction of apoptosis by sodium butyrate in the human Y-79 retinoblastoma cell line. Oncol Res 1995; 7:289-297.
47. Heerdt BG, Houston MA, Augenlicht LH. Short-chain fatty acid-initiated cell cycle arrest and apoptosis of colonic epithelial cells is linked to mitochondrial function. Cell Growth Differ 1997; 8:523-532.
48. Gupta S, Alpini G, Vemuru RP, et al. Butyrate synchronization of hepatocytes: modulation of cycling and cell cycle regulated gene expression. Growth Factors 1994; 10:171-180.
49. Boyd JM, Gallo GJ, Elangovan B, et al. Bik, a novel death-inducing protein, shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene 1995; 11:1921-1928.
50. Han J, Sabbatini P, White E. Induction of apoptosis by Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. Mol Cell Biol 1996; 16:5857-5864.
51. Elangovan B, Cinnadurai G. Function dissection of the pro-apoptotic protein Bik. J Biol Chem 1997; 272:24494-24498.