Ligand-dependent and -independent interactions with the transforming growth factor type II and I receptor subunits reside in the aminoterminal portion of the ectodomain of the type III subunit

In Vitro Cellular and Developmental Biology - Animal

Volumn 34, Issue 3, 1998, Pages 232-238

  Taniguchi, Akiyoshi ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Cytokines; FGF; Growth control; Growth factors; Heparan sulfate; Heparin

Indexed keywords

AMINO ACID; CYTOKINE; HEPARAN SULFATE; HEPARIN; LIGAND; PHOSPHOTRANSFERASE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; GROWTH REGULATION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LEPIDOPTERA; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ANIMALIA; INSECTA; LEPIDOPTERA;

EID: 0032452292     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-998-0129-3     Document Type: Article

References (17)

1. Cheifetz, S.; Massague, J. Transforming growth factor-β (TGF-β) receptor proteoglycan. J. Biol. Chem. 261:12025-12028; 1989.
2. Fukushima, D.; Butzow, R.; Hildebrand, A., et al. Localization of transforming growth factor β binding site in betaglycan. J. Biol. Chem. 268:22710-22715; 1993.
3. Hou, J.; Kan, M.; McKeehan, K., et al. Fibroblast growth factor receptors from liver vary in three structural domains. Science 251:665-668; 1991.
4. Kaname, S.; Ruoslahti, E. Betaglycan has multiple binding sites for transforming growth factor-β1. Biochem. J. 315:815-820; 1996.
5. Lopez-Casillas, F.; Payne, H. M.; Andres, J. L., et al. Betaglycan can act as a dual modulator of TGF-β access to signaling receptors: mapping of ligand binding and GAG attachment sites. J. Cell Biol. 124:557-568; 1994.
6. Lopez-Casillas, F.; Wrana, J. L.; Massague, J. Betaglycan presents ligand to the TGFβ signaling receptor. Cell 73:1435-1444; 1993.
7. Luo, K. X.; Lodish, H. F. Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduclion. EMBO J. 15:4485-1496; 1996.
8. Matsuzaki, K.; Kan, M.; McKeehan, W. L. Reconstitution of a pentameric complex of dimeric transforming growth factor beta ligand and a type I, II, III receptor in baculoviral-infected insect cells. In Vitro Cell. Dev. Biol. 32A:3 45-360; 1996.
9. McCaffrey, T. A.; Falcone, D. J.; Brayton, C. F., et al. Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex. J. Cell Biol. 109:4-11-148; 1989.
10. McCaffrey, T. A.; Falcone, D. J.; Du, B. Transforming growth factor-beta 1 is a heparin-binding protein: identification of putative heparin-binding regions and isolation of heparins with varying affinity for TGF-beta 1. J. Cell. Phys. 152:430-1-10; 1992.
11. Moustakas, A.; Lin, H. Y.; Henis, Y. I., et al. The transforming growth factor β receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand. J. Biol. Chem. 268:22215-22218; 1993.
12. Pepin, M.-C.; Beauchemin, M.; Collins, C., et al. Mutagenesis analysis of the membrane-proximal ligand binding site of the TGFβ receptor type III extracellular domain. FEES Lett. 377:368-372; 1995.
13. Pepin, M.-C.; Beauchemin, M.; Plamondon, J., et al. Mapping of the ligand binding domain of the transforming growth factor β receptor type III by deletion mutagenesis. Proc. Natl. Acad. Sci. USA 91:6997-7001; 1994.
14. Weis-Garcia, F.; Massague, J. Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling. EMBO J. 15:276-289; 1996.
15. Wrana, J. L.; Attisano, L.; Carcama, J., et al. TGFβ signals through a heteromeric protein kinase receptor complex. Cell 71:1003-1014; 1992.
16. Yamashita, H.; Hidenori, I.; Grimsby, S., et al. Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-β. J. Biol. Chem. 269:1995-2001; 1994.
17. Yamashita, H.; ten Dijke, P.; Franzen, P., et al. Formation of heterooligomeric complexes of type I and type II receptors for transforming growth factor-β. J. Biol. Chem. 269:20172-20178; 1994.