Activity of oral and intravenous 9-aminocamptothecin in SCID mice engrafted with human leukemia

Leukemia and Lymphoma

Volumn 32, Issue 1-2, 1998, Pages 159-164

  Jeha, Sima ^a   Kantarjian, Hagop ^a   O'Brien, Susan ^a   Vitek, Lauren ^b   Beran, Miloslav ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b Pharmacia/Adria   (United States)

Author keywords

9 AC; Acute myeloblastic leukemia; Aminocamptothecin; AML; SCID mouse

Indexed keywords

9 AMINOCAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; DNA DETERMINATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCID MOUSE;

EID: 0032450840     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199809059256     Document Type: Article

References (17)

1. Giovanella, B.C., Stehlin, J.S., Wall M.E., Wani, M.C., Nicholas, A.W., Liu, L.F., Silber, R. and Pomesil, M. (1989) DNA Topoisomerase I-targeted chemotherapy of human colon cancer xenografts. Science 246:1046-1048.
2. Hsiang, Y.H., Hertzberg, R., Hecht, S. and Liu, L.F. (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 260:14873-14878.
3. Hsiang, Y.H. and Liu, L.F. (1988) Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res 48:1722-1726.
4. Hertzberg, R.P., Caranfa, M.J. and Hecht, S.M. (1989) On the mechanism of topoisomerase I inhibition by camptothecin: evidence of binding to an enxyme-DNA complex. Biochem 28:4629-4638.
5. Pantazis, P., Hinz, H.R., Mendoza, J.T., Kozielski, A.S., Williams, L.J., Stehlin, J.S., Jr. and Giovanella, B.C. (1992) Complete inhibition of growth followed by death of human malignant melanoma cells in vitro and regression of human xenografts in immunodeficient mice induced by camptothecins. Cancer Res 52:3980-3987.
6. Wani, M.C., Nicholas, A.W. and Wall, M.E. (1986) Plant antitumor agents: synthesis and antileukemic activity of camptothecin analogues. J Med Chem 29:2353-2363.
7. Saiki, N.K., Brigawan, T.L., Horn, G.T., Mullis, K.B. and Ehlich, H.A. (1986) Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotides probes. Nature 324:163.
8. Kawasaki, E.S. (1990) Sample preparation from blood, cells and other fluids. In PCR Protocols. A Guide to Methods and Applications, edited by M.A. Innis, D.H. Gelfand, J.J. Snishy and T.H. White, p. 146. San Diego: Academic.
9. Beran, M., Pisa, P., Kantarjian, H., Porwit, A and Björkholm, M. (1994) Growth of sensitive and drug-resistant human myeloid leukemia cells in SCID mice. Hematol Pathol 8:135.
10. Hsu, H.M., Raine, L. and Fanger, H. (1981) Use of avidin-biotin-peroxidase techniques: a comparison between ABC and unlabeled (PAP) procedures. J Histochem Cytochem 29:577.
11. Champlin, R and Gale, R.P. (1987) Acute myelogenous leukemia: recent advances in therapy. Blood 69:1551-1562.
12. Vogler, W.R., Velez-Garcia, E., Weiner, R.S., Flaum, M.A., Bartolucci, A.A., Omura, G.A., Gerber, M.C. and Banks, P.L.C. (1992) A phase III trial comparing Idarubicin and Daunorubicin in combination with Cytarabine in acute myelogenous leukemia: a Southeastern Cancer Study Group study. J Clin Oncol 10:1103-1111.
13. Jeha, S., Kantarjian, H., O'Brien, S., Huh, Y., Pisa, P., Ordonez, N. and Beran, M. (1995) Growth and biologic properties of karyotypically defined subcategories of adult acute lymphocytic leukemia in mice with severe combined immunodeficiency. Blood 86(11) :4278-4285.
14. Cesano, A., O'Connor, R., Lange, B., Finan, J., Rovera, G. and Santoli, D. (1991) Homing and progression patterns of childhood acute lymphoblastic leukemias in severe combined immunodeficiency mice. Blood 77:2463.
15. Kamel-Reid, S., Letarte, M., Doedens, M., Greaves, A., Murdoch, B., Grenberger, T., Lapidot, T., Thorner, P., Freedman, M.H., Phillips, R.A. and Dick, J.E. (1991) Bone marrow from children in relapse with pre-B acute lymphoblastic leukemia proliferates and disseminates rapidly in SCID mice. Blood 79:2973.
16. Uckun, F. (1996) Severe combined immunodeficicnt mouse models of human leukemia. Blood 96:1135-1146.
17. Beran, M., Jeha, S., O'Brien, S., Estey, E., Vitek, L., Zurlo, M.G., Rios, M.B., Keating, M.J. and Kantarjian, H.M. (1997) Tallimustine, an effective antileukemic agent in severe combined immunodeficient mouse model of adult myelogenous leukemia, induces remissions in a Phase I study. Clin Cancer Res 3:2377-2384.