Evidence for functional native NMDA receptors activated by glycine or D-serine alone in the absence of glutamatergic coagonist

European Journal of Neuroscience

Volumn 10, Issue 9, 1998, Pages 2934-2944

  Paudice, Paolo ^a   Gemignani, Anita ^a   Raiteri, Maurizio ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Glutamate receptor subtypes; Neuropeptide release; NMDA receptor subunits; Rat neocortex; Strychnine insensitive glycine receptors

Indexed keywords

CHOLECYSTOKININ; DEXTRO SERINE; GLYCINE; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPEPTIDE; SOMATOSTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EVOKED RESPONSE; IMMUNOREACTIVITY; MALE; NEOCORTEX; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTOSOME;

ANIMALS; CEREBRAL CORTEX; CHOLECYSTOKININ; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GLUTAMIC ACID; GLYCINE; MALE; N-METHYLASPARTATE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SERINE; SOMATOSTATIN; STEREOISOMERISM; SYNAPTOSOMES;

EID: 0032449646     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1998.00302.x     Document Type: Article

References (21)

1. Bandopadhyay, R. & de Belleroche, J. (1991) Regulation of CCK release in cerebral cortex by N-methyl-d-aspartate receptors: Sensitivity to APV, MK-801, kynurenate, magnesium and zinc ions. Neuropeptides, 18, 159-163.
2. Beinfeld, M.C. (1995) Cholecystokinin/gastrin. In Bloom, F.E. & Kupfer, D.J. (eds), Psychopharmacology: the Fourth Generation of Progress. Raven Press, New York, pp. 585-594.
3. B receptors. Trends Pharmacol. Sci., 14, 259-261.
4. Bonanno, G., Raiteri, M. & Emson, P.C. (1988) In vitro release of somatostatin from cerebral cortical slices: characterization of electrically-evoked release. Brain Res., 447, 92-97.
5. Bonanno, G., Parodi, B., Cafaggi, S. & Raiteri, M. (1991) Somatostatin release from rat cerebral cortex synaptosomes. J. Neurochem., 57, 1258-1264.
6. Bormann, J. (1989) Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channel. Eur. J. Pharmacol., 166, 591-592.
7. Bradford, M.M. (1976) A rapid and sensitive method for quantitation of microgram quantities of proteins utilizing the principles of protein-dye binding. Anal. Biochem., 72, 248-254.
8. Buller, A.L., Larson, H.C., Schneider, B.E., Beaton, J.A., Morrisett, R.A. & Monaghan, D.T. (1994) The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition. J. Neurosci., 14, 5471-5484.
9. Carter, C.J., Lloyd, K.G., Zivkovic, B. & Scatton, B. (1990) Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex. J. Pharmacol. Exp. Ther., 253, 475-482.
10. Chen, N., Moshaver, A. & Raymond, L.A. (1997) Differential sensitivity of recombinant N-methyl-D-aspartate receptor subtypes to zinc inhibition. Mol. Pharmacol., 51, 1015-1023.
11. Chen, H.S.V., Pellegrini, J.W., Aggarwal, S.K., Lei, S.Z., Warach, S., Jensen, F.E. & Lipton, S.A. (1992) Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J. Neurosci., 12, 4427-4436.
12. 3H]dopamine release. Br. J. Pharmacol., 117, 595-606.
13. Crawley, J.N. & Corwin, R.L. (1994) Biological actions of cholecystokinin. Peptides, 15, 731-755.
14. Dawbarn, D., DeQuidt, M.F. & Emson, P.C. (1985) Survival of basal ganglia neuropeptide Y/somatostatin neurones in Huntington's disease. Brain Res., 340, 251-260.
15. Desce, J.M., Godeheu, G., Galli, T., Artaud, F., Chéramy, A. & Glowinski, J. (1992) L-Glutamate-evoked release of dopamine from synaptosomes of the rat striatum: involvement of AMPA and N-methyl-D-aspartate receptors. Neuroscience, 47, 333-339.
16. 3H]GABA from cultured mouse cerebral cortex interneurons. J. Neurosci., 7, 2910-2916.
17. Durand, G.M., Gregor, P., Zheng, X., Bennett, M.L., Uhl, G.R. & Zukin, R.S. (1992) Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators protein kinase C. Proc. Natl Acad. Sci. USA, 89, 9359-9363.
18. Ebert, B., Wong, E.H.F. & Krogsgaard-Larsen, P. (1991) Identification of a novel NMDA receptor in rat cerebellum. Eur. J. Pharmacol. Mol. Pharmacol., 208, 49-52.
19. Fadda, E., Danysz, W., Wroblewski, J.T. & Costa, E. (1988) Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes. Neuropharmacology, 27, 1183-1185.
20. Fink, K., Bönisch, H. & Göthert, M. (1990) Presynaptic NMDA receptors stimulate noradrenaline release in the cerebral cortex. Eur. J. Pharmacol., 185, 115-117.
21. Fink, K., Schmitz, V., Boing, C. & Göthert, M. (1995) Stimulation of serotonin release in the rat brain cortex by activation of ionotropic glutamate receptors and its modulation via α2 heteroreceptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 352, 394-401.