Developmental changes in synthesis of and responsiveness to prostaglandins I2 and E2 in hypoxic lamb lungs

Canadian Journal of Physiology and Pharmacology

Volumn 76, Issue 7-8, 1998, Pages 764-771

  De Cléty, Stéphan Clément ^a   Decell, Mary K ^a   Tod, Mary L ^b   Sirois, Pierre ^c   Gordon, John B ^a,b,d  

^a MONTREAL CHILDREN S HOSPITAL   (Canada)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SHERBROOKE   (Canada)

^d CHILDREN S HOSPITAL OF WISCONSIN   (United States)

Author keywords

Cyclooxygenase inhibition; Hypoxic pulmonary vasoconstriction; Pulmonary vascular development; Segmental vascular resistances

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; OXYGEN; PROSTACYCLIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PH; CARBON DIOXIDE TENSION; CONTROLLED STUDY; ENZYME INHIBITION; HYPOXIA; LAMB; LUNG DEVELOPMENT; LUNG VASCULAR RESISTANCE; LUNG VASOCONSTRICTION; NEWBORN; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS;

EID: 0032449325     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y98-092     Document Type: Article

References (33)

1. Abman, S.H., and Stenmark, K.R. 1992. Changes in lung eicosanoid content during normal and abnormal transition in perinatal lambs. Am. J. Physiol. 262: L214-L222.
2. Abman, S.H., Chatfield, B.A., Hall, S.L., and McMurtry, I.F. 1990. Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth. Am. J. Physiol. 259: H1921-H1927.
3. Albertini, M., Vanelli, G., and Clement, M.G. 1996. PGI2 and nitric oxide involvement in the regulation of systemic and pulmonary basal vascular tone in the pig. Prostaglandins Leukotrienes Essent. Fatty Acids, 54: 273-278.
4. 2. Am. J. Physiol. 236: H828-H832.
5. Cassin, S., Gause, G., Davis, T., ter Riet, M., and Baker, R. 1989. Do inhibitors of lipoxygenase and cyclooxygenase block neonatal hypoxic pulmonary vasoconstriction. J. Appl. Physiol. 66: 1779-1784.
6. Chida, M., and Voelkel, N.F. 1996. Effects of acute and chronic hypoxia on rat lung cyclooxygenase. Am. J. Physiol. 270: L872-L878.
7. Cornfield, D.N., Chatfield, B.A., McQueston, J.A., McMurtry, I.F., and Abman, S.H. 1992. Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus. Am. J. Physiol. 262: H1474-H1481.
8. Durmowicz, A.G., Orton, E.C., and Stenmark, K.R. 1993. Progressive loss of vasodilator responsive component of pulmonary hypertension in neonatal calves exposed to 4,570 m. Am. J. Physiol. 265: H2175-H2183.
9. Fike, C.D., and Kaplowitz, M.R. 1994. Developmental differences in vascular responses to hypoxia in lungs of rabbits. J. Appl. Physiol. 77: 507-516.
10. Fike, C.D., Gordon, J.B., and Kaplowitz, M.R. 1993. Micropipette and vascular occlusion pressures in isolated lungs of newborn lambs. J. Appl. Physiol. 75: 1854-1860.
11. Gordon, J.B., Tod, M.L., Wetzel, R.C., McGeady, M.L., Adkinson, N.F., Jr., and Sylvester, J.T. 1988. Age-dependent effects of indomethacin on hypoxic vasoconstriction in neonatal lamb lungs. Pediatr. Res. 23: 580-584.
12. Gordon, J.B., Hortop, J., and Hakim, T.S. 1989. Developmental effects of hypoxia and indomethacin on distribution of vascular resistances in lamb lungs. Pediatr. Res. 26: 325-329.
13. Gordon, J.B., Martinez, F.R., O'Donnell, D.C., and Tod, M.L. 1995. Effects of hypoxia and vascular tone on endothelium-dependent and -independent responses in developing lungs. J. Appl. Physiol. 79: 824-830.
14. Gordon, J.B., Moreira, G.A., O'Donnell, D.C., Aldinger, A.M., and Tod, M.L. 1997. Relative effects of cyclooxygenase and nitric oxide synthase inhibition in neonatal lamb lungs. Pediatr. Res. 42: 738-743.
15. Green, R.S., and Leffler, C.W. 1984. Hypoxia stimulates prostacyclin synthesis by neonatal lungs. Pediatr. Res. 18: 832-835.
16. Haworth, S.G., and Hislop, A.A. 1981. Normal structural and functional adaptation to extrauterine life. J. Pediatr. 98: 915-918.
17. Hyman, A.L., and Kadowitz, P.J. 1988. Tone-dependent responses to acetylcholine in the feline pulmonary vascular bed. J. Appl. Physiol. 64: 2002-2009.
18. Leffler, C.W., Hessler, J.R., and Green, R.S. 1984. The onset of breathing stimulates pulmonary vascular prostacyclin synthesis. Pediatr. Res. 18: 938-942.
19. Lock, J.E., Olley, P.M., and Coceani, F. 1980. Direct pulmonary vascular responses to prostaglandins in the conscious newborn lamb. Am. J. Physiol. 238: H631-H638.
20. Michel, R.P., Gordon, J.B., and Chu, K. 1991. Development of the pulmonary vasculature in newborn lambs: structure-function relationships. J. Appl. Physiol. 70: 1255-1264.
21. North, A.J., Brannon, T.S., Wells, L.B., Campbell, W.B., and Shaul, P.W. 1994. Hypoxia stimulates prostacyclin synthesis in newborn pulmonary artery endothelium by increasing cyclooxygenase-1 protein. Circ. Res. 75: 33-40.
22. Olson, D.M., Lye, S.J., and Challis, J.R.G. 1986. Prostaglandin concentrations in ovine maternal and fetal tissues at late gestation. Pediatr. Res. 20: 83-86.
23. Owen-Thomas, J.B., and Reeves, J.T. 1969. Hypoxia and pulmonary artery pressure in the rabbit. J. Physiol. (London), 201: 665-672.
24. Pradelles, P.J., Grassi, J., and Maclouf, J. 1985. Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay. Anal. Chem. 57: 1170-1173.
25. Printz, M.P., Skidgel, R.A., and Friedman, W.F. 1984. Studies of pulmonary prostaglandin biosynthetic and catabolic enzymes as factors in ductus arteriosus patency and closure. Evidence for a shift in products with gestational age. Pediatr. Res. 18: 19-24.
26. Rendas, A., Branthwaite, M., Lennox, S., and Reid, L. 1982. Response of the pulmonary circulation to acute hypoxia in the growing pig. J. Appl. Physiol. 52: 811-814.
27. Shaul, P.W., Farrar, M.A., and Magness, R.R. 1993. Oxygen modulation of pulmonary arterial prostacyclin synthesis is developmentally regulated. Am. J. Physiol. 265: H621-H628.
28. 2 in perinatal rabbit lungs. Prostaglandins, 26: 275-285.
29. Tod, M.L., and Sylvester, J.T. 1989. Distribution of pulmonary vascular pressure as a function of perinatal age in lambs. J. Appl. Physiol. 66: 79-87.
30. Tod, M.L., Yoshimura, K., and Rubin, L.J. 1991. Indomethacin prevents ventilation-induced decreases in pulmonary vascular resistance of the middle region in fetal lambs. Pediatr. Res. 29: 449-454.
31. 1α in the canine lung. Prostaglandins Leukotrienes Med. 20: 275-282.
32. Tyler, T., Wallis, R., Leffler, C., and Cassin, S. 1975. The effects of indomethacin on the pulmonary vascular response to hypoxia in the premature and mature newborn goat (39108). Exp. Biol. Med. 150: 695-698.
33. 2, from isolated rat lung during vasoconstriction. Circ. Res. 48: 207-213.