Regulation of expression of GLT1, the gene encoding glutamate synthase in Saccharomyces cerevisiae

Journal of Bacteriology

Volumn 180, Issue 14, 1998, Pages 3533-3540

  Valenzuela, Lourdes ^a   Ballario, Paola ^b   Aranda, Cristina ^a   Filetici, Patrizia ^b   González, Alicia ^a  

^a INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE SYNTHASE; GLUTAMIC ACID; TRANSCRIPTION FACTOR;

AMINO ACID SYNTHESIS; ARTICLE; ENZYME SUBUNIT; GENE EXPRESSION REGULATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0032448052     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.180.14.3533-3540.1998     Document Type: Article

References (47)

1. André, B. 1990. The UGA3 gene regulating the GABA catabolic pathway in Saccharomyces cerevisiae codes for a putative zinc-finger protein acting on RNA amount. Mol. Gen. Genet. 220:269-276.
2. Avendaño, A., A. DeLuna, H. Olivera, L. Valenzuela, and A. González. 1997. GDH3 encodes a glutamate dehydrogenase isozyme, a previously unrecognized route for glutamate biosynthesis in Saccharomyces cerevisiae. J. Bacteriol. 179:5594-5597.
3. Barel, I., and D. W. MacDonald. 1993. Enzyme defects in glutamate-requiring strains of Schizosaccharomyces pombe. FEMS Microbiol. Lett. 113:267-272.
4. Blinder, D., and B. Magasanik. 1995. Recognition of nitrogen-responsive upstream activation sequences of Saccharomyces cerevisiae by the product of the GLN3 gene. J. Bacteriol. 177:4190-4193.
5. Blinder, D., P. W. Coschigano, and B. Magasanik. 1996. Interaction of the GATA factor Gln3p with the nitrogen regulator Ure2p in Saccharomyces cerevisiae. J. Bacteriol. 178:4734-4736.
6. Bohannon, D. E., and A. L. Sonenshein. 1989. Positive regulation of glutamate biosynthesis in Bacillus subtilis. J. Bacteriol. 171:4718-4727.
7. Bohannon, D. E., M. S. Rosenkrantz, and A. L. Sonenshein. 1985. Regulation of Bacillus subtilis glutamate synthase genes by the nitrogen source. J. Bacteriol. 163:957-964.
8. Bravo, A., and J. Mora. 1988. Ammonium assimilation in Rhizobium phaseoli by glutamine synthetase-glutamate synthase pathway. J. Bacteriol. 170:980-984.
9. Castaño, I., F. Bastarrachea, and A. A. Covarrubias. 1988. gltBDF operon of Escherichia coli. J. Bacteriol. 170:821-827.
10. Castaño, I., N. Flores, F. Valle, A. A. Covarrubias, and F. Bolivar. 1992. gltF, a member of the gltBDF operon of Escherichia coli, is involved in nitrogen regulated gene expression. Mol. Microbiol. 6:2733-2741.
11. Coffman, J. A., R. Rai, D. M. Loprete, T. Cunninham, V. Svetlov, and T. G. Cooper. 1997. Cross regulation of four GATA factors that control nitrogen catabolic gene expression in Saccharomyces cerevisiae. J. Bacteriol. 179:3416-3429.
12. Cogoni, C., L. Valenzuela, D. González-Halphen, H. Olivera, G. Macino, P. Ballario, and A. González. 1995. Saccharomyces cerevisiae has a single glutamate synthase gene coding for a plant-like high-molecular-weight polypeptide. J. Bacteriol. 177:792-798.
13. Coornaert, D., S. Vissers, B. Andre, and M. Grenson. 1992. The UGA43 negative regulatory gene of Saccharomyces cerevisiae contains both a GATA-1 type zinc finger and a putative leucine zipper. Curr. Genet. 21:301-307.
14. Csonka, L. N., T. P. Ikeda, S. A. Fletcher, and S. Kustu. 1994. The accumulation of glutamate is necessary for optimal growth of Salmonella typhimurium in media of high osmolality but not induction of the proU operon. J. Bacteriol. 176:6324-6333.
15. GATA). J. Bacteriol. 175:5851-5861.
16. Ernsting, B. R., J. W. Denninger, R. M. Blumenthal, and R. G. Matthews. 1993. Regulation of the gltBDF operon of Escherichia coli: how is a leucine-insensitive operon regulated by the leucine responsive regulatory protein? J. Bacteriol. 175:7160-7169.
17. Filetici, P., M. P. Martegani, L. Valenzuela, A. González, and P. Ballario. 1996. Sequence of the GLT1 gene from Saccharomyces cerevisiae reveals the domain structure of yeast glutamate synthase. Yeast 12:1359-1366.
18. Folch, J. L., A. Antaramián, L. Rodríguez, A. Bravo, A. Brunner, and A. González. 1989. Isolation and characterization of a Saccharomyces cerevisiae mutant with impaired glutamate synthase activity. J. Bacteriol. 171:6776-6781.
19. Harbury, P. A. B., and K. Struhl. 1989. Functional distinctions between yeast TATA elements. Mol. Cell. Biol. 9:5298-5304.
20. Helling, R. B. 1994. Why does Escherichia coli have two primary pathways for synthesis of glutamate? J. Bacteriol. 176:4664-4668.
21. Hinnebusch, A. G. 1985. A hierarchy of trans-acting factors modulated translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 5:2349-2360.
22. Hinnebusch, A. G. 1986. The general control of amino acid biosynthetic genes in the yeast Saccharomyces cerevisiae. Crit. Rev. Biochem. 21:277-317.
23. Holmes, A. R., A. Collings, K. J. F. Farnden, and M. G. Sheperd. 1989. Ammonium assimilation by Candida albicans and other yeasts: evidence for activity of glutamate synthase. J. Gen. Microbiol. 135:1423-1430.
24. Holzer, H., and S. Schneider. 1957. Anreicherung und Trennung einer DPN-spezifischen und einer TPN-spezifischen Glutaminosaure Dehydrogenase aus Hefe. Biochem. Z. 329:361-367.
25. Hummelt, G., and J. Mora. 1980. Regulation and function of glutamate synthase in Neurospora crassa. Biochem. Biophys. Res. Commun. 96:1688-1694.
26. Ito, H., Y. Fukuda, K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153:163-168.
27. 6 binuclear cluster proteins recognize DNA. Mol. Cell. Biol. 16:3773-3780.
28. Lomnitz, A., J. Calderón, G. Hernandez, and J. Mora. 1987. Functional analysis of ammonium assimilation enzymes in Neurospora crassa. J. Gen. Microbiol. 133:2333-2340.
29. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
30. Marqués, S., F. J. Florencio, and P. Candau. 1992. Purification and characterization of the ferredoxin-glutamate synthase from the unicellular cyanobacterium Synechoccus sp. PCC 6301. Eur. J. Biochem. 206:69-77.
31. Mavrothalassitis, G., G. Beal, and T. S. Papas. 1990. Defining target sequences of DNA-binding proteins by random selection and PCR: determination of the GCN4 binding sequence repertoire. DNA Cell. Biol. 9:783-788.
32. Miflin, B. J., P. J. Lea, and R. M. Wallsgrove. 1980. The role of glutamine in amonnium assimilation and reassimilation in plants, p. 213-234. In J. Mora and R. Palacios (ed.), Glutamine: metabolism, enzymology and regulation. Academic Press, Inc., New York, N.Y.
33. Miller, S. M., and B. Magasanik. 1990. Role of NAD-linked glutamate dehydrogenase in nitrogen metabolism in Saccharomyces cerevisiae. J. Bacteriol. 172:4927-4935.
34. Minehart, P. L., and B. Magasanik. 1991. Sequence and expression of GLN3, a positive regulatory gene of Saccharomyces cerevisiae encoding a protein with a putative zinc finger DNA-binding domain. Mol. Cell. Biol. 11:6216-6228.
35. Myers, A. M., A. Tzagaloff, D. M. Kinney, and C. J. Lusty. 1986. Yeast shuttle integrative vectors with multiple cloning sites suitable for construction of lacZ fusions. Gene 45:299-310.
36. NTR functioning in combination with other UAS elements underlies exceptional patterns of nitrogen regulation in Saccharomyces cerevisiae. Yeast 11:247-260.
37. Rose, M., and D. Botstein. 1983. Construction and use of gene fusions lacZ (β-galactosidase) which are expressed in yeast. Methods Enzymol. 101:167-180.
38. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
39. 6 zinc cluster family of transcriptional regulators. Nucleic Acids Res. 24:4599-4607.
40. Senior, P. J. 1975. Regulation of nitrogen metabolism in Escherichia coli and Klebsiella aerogenes: studies with the continuous-culture technique. J. Bacteriol. 123:407-418.
41. Stanbrough, M., and B. Magasanik. 1996. Two transcription factors, Gln3p and Nil1p, use the same GATAAG sites to activate the expression of GAP1 of Saccharomyces cerevisiae. J. Bacteriol. 178:2465-2468.
42. Stanbrough, M., R. D. W. Rowen, and B. Magasanik. 1995. Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes. Proc. Natl. Acad. Sci. USA 92:9450-9454.
43. Struhl, K. 1985. Naturally occurring poly(dA-dT) sequences are upstream promoter elements for constitutive transcription in yeast. Proc. Natl. Acad. Sci. USA 82:8419-8423.
44. Tavernarakis, N., and G. Thireos. 1997. The DNA target sequence influences the dependence of the yeast transcriptional activator GCN4 on cofactors. Mol. Gen. Genet. 253:766-769.
45. Tempest, D. W., J. L. Meers, and C. M. Brown. 1970. Synthesis of glutamate in Aerobacter aerogenes by hitherto unknown route. Biochem. J. 117:405-507.
46. +-glutamate dehydrogenase mutant of the petit-negative yeast Kluyveromyces lactis uses the glutamine synthase-glutamate synthase pathway for glutamate biosynthesis. Microbiology 141:2443-2447.
47. Vishwanath, I., and K. Struhl. 1995. Poly (dA:dT), a ubiquitous promoter element that stimulates transcription via its intrinsec DNA structure. EMBO J. 14:2570-2579.