Fetal cells from maternal blood: Purpose, biological questions, technical challenges

Intervirology

Volumn 41, Issue 4-5, 1998, Pages 226-231

  Bohmer, Ralph M ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

Cell traffic, fetomaternal; Diagnosis, prenatal; DNA, fetal; Immunity, fetomaternal; Infections, fetal

Indexed keywords

CELL ISOLATION; CELL STRUCTURE; FETUS; FETUS CELL; GENETIC DISORDER; HUMAN; INTRAUTERINE INFECTION; MATERNAL BLOOD; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; REVIEW;

BLOOD SPECIMEN COLLECTION; DNA; FEMALE; FETAL DISEASES; FETOMATERNAL TRANSFUSION; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PRENATAL DIAGNOSIS;

EID: 0032448010     PISSN: 03005526     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024941     Document Type: Review

References (14)

1. Bianchi DW, Williams JM, Sullivan SM, Hanson FW, Klinger KW, Shuber AP: PCR quantitation of fetal cells in maternal blood in normal and aneuploid pregnancies. Am J Hum Genet 1997;61:822-829.
2. Bianchi DW: Current knowledge about fetal blood cells in the maternal circulation. J Perinat Med 1998;26:175-185.
3. Wood GW: Is restricted antigen presentation the explanation for fetal allograft survival? Immunol Today 1994;15:16.
4. Bonney EA, Matzinger P: The maternal immune system's interaction with circulating fetal cells. J Immunol 1997;158:40.
5. Williams GT, Smith CA, Spooncer E, Dexter TM, Taylor DR: Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 1990;343:76.
6. Bianchi DW, Zickwolf GK, Weil GJ, Sylvester S, DeMaria MA: Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc Natl Acad Sci USA 1996;93: 705-708.
7. Nelson JL, Furst DE, Maloney S, Gooley T, Evans PC, Smith A, Bean MA, Ober C, Bianchi DW: Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. Lancet 1998;351:559-562.
8. Thomas MR, Tutschek B, Frost A, Rodeck CH, Yazdani N, Craft I, Williamson R: The time of appearance and disappearance of fetal DNA from the maternal circulation. Prenat Diagn 1995;15:641.
9. Hahn S, Sant R, Holzgreve W: Fetal cells in maternal blood: current and future perspectives. Mol Hum Reprod 1998;4:515.
10. Zheng YL, DeMaria M, Zhen DK, Vadnais TJ, Bianchi DW: Flow sorting of fetal erythroblasts using intracytoplasmic anti-fetal haemoglobin: Preliminary observations on maternal samples. Prenat Diagn 1995;15:897-905.
11. Mayani H, Little MT, Dragowska W, Thornbury G, Lansdorp PM: Differential effects of the hematopoietic inhibitors MIP-1α, TGF-β, and TNF-α on cytokine-induced proliferation of subpopulations of CD34+ cells purified from cord blood and fetal liver. Exp Hematol 1995; 23:422-427.
12. Bohmer RM, Zhen DK, Bianchi DW: Differential development of fetal and adult haemoglobin profiles in colony culture: isolation of fetal nucleated red cells by two-color fluorescence labelling. Br J Haematol 1998;103:351-360.
13. Bohmer RM, Zhen DK, Bianchi DW: Identification of fetal nucleated red cells in co-cultures from fetal and adult peripheral blood: Differential effects of serum on fetal and adult erythropoiesis. Prenat Diagn 1999, in press.
14. Valerio D, Aiello R, Altieri V, Malato AP, Fortunato A, Canazio A: Culture of fetal erythroid progenitor cells from maternal blood for non-invasive prenatal genetic diagnosis. Prenat Diagn 1996;16:1073-1082.