Intravesical electromotive drug administration technique: Preliminary results and side effects

Journal of Urology

Volumn 159, Issue 6, 1998, Pages 1851-1856

  Riedl, Claus R ^a   Knoll, Marlies ^a   Plas, Eugen ^a   Pflüger, Heinz ^a  

^a LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

Administration; Bladder diseases; Intravesical; Iontophoresis

Indexed keywords

ADRENALIN; BETHANECHOL; DEXAMETHASONE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEPIVACAINE; MIDAZOLAM; MITOMYCIN C; OXYBUTYNIN; SEDATIVE AGENT;

ADULT; AGED; ARTICLE; BLADDER CANCER; BLADDER CATHETERIZATION; BLADDER CONTRACTION; BLADDER DISEASE; CLINICAL TRIAL; CYSTITIS; DETRUSOR MUSCLE; DYSURIA; FEMALE; HUMAN; INTERSTITIAL CYSTITIS; INTRAVENOUS DRUG ADMINISTRATION; INTRAVESICAL DRUG ADMINISTRATION; IONTOPHORESIS; MAJOR CLINICAL STUDY; MALE; NEUROGENIC BLADDER; PRIORITY JOURNAL; URGE INCONTINENCE; URODYNAMICS;

EID: 0032445856     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)63174-4     Document Type: Article

References (22)

1. Stillwell, G. K.: Electric Stimulation and iontophoresis. In: Handbook of Physical Medicine and Rehabilitation, 2nd ed. Edited by F. H. Krussen. St. Louis: W. B. Saunders Co., chapt. 14, 1971.
2. Teruo, M., Watanabe, H. and Kobayashi, T.: Absorption of anti-cancer drugs through bladder epithelium. Urology, 27: 148, 1986.
3. Hicks, R. M., Ketterer, B. and Warren, R. C.: The ultrastructure and chemistry of the luminal plasma membrane of the mammalian urinary bladder: a structure with low permeability to water and ions. Phil. Trans. Roy. Soc. London Biol. Sci., 268: 23, 1974.
4. Thiel, K. H.: Die intravesikale antineoplastische Iontophorese - Ein unblutiges Verfahren zur Therapie und Rezidivprophylaxe des Blasenkarzinoms. In: Verhandlungsbericht der Deutschen Gesellschaft für Urologie, 40. Tagung, Springer Verlag, 1988.
5. Lugnani, F., Mazza, G., Cerulli, N., Rossi, C. and Stephen, R. L.: Iontophoresis of drugs in the bladder wall: equipment and preliminary studies. Artif. Org., 17: 8, 1993.
6. Gürpinar, T., Truong, L. D., Wong, H. Y. and Griffith, D. P.: Electromotive drug administration to the urinary bladder: an animal model and preliminary results. J. Urol., 156: 1496, 1996.
7. Di Stasi, S. M., Vespasiani, G., Giannantoni, A., Massoud, R., Dolci, S. and Micali, F.: Electromotive delivery of mitomycin C into human bladder wall. Cancer Res., 57: 875, 1997.
8. Di Stasi, S. M., Giannantoni, A., Massoud, R., Cortese, C., Vespasiani, G. and Micali, F.: Electromotive administration of oxybutynin into the human bladder wall. J. Urol., 158: 228, 1997.
9. Riedl, C. R., Knoll, M. and Pflüger, H.: Detrusor stimulation by intravesical EMDA of bethanechol. J. Endourol., suppl. 10: P7-236, 1996.
10. Dasgupta, P., Fowler, C. J., Hoverd, P., Haslam, C., Penberthy, R., Shah, J. and Stephen, R. L.: Does electromotive drug administration (EMDA) with lignocaine before intravesical capsaicin confer benefit? J. Urol., part 2, 157: 186, abstract 724, 1997.
11. Gürpinar, T., Wong, H. Y. and Griffith, D. P.: Electromotive administration of intravesical lidocaine in patients with interstitial cystitis. J. Endourol., 10: 443, 1996.
12. Fontanella, U. A., Rossi, C. A. and Stephen, R. L.: Bladder and urethral anaesthesia with electromotive drug administration (EMDA): a technique for invasive endoscopic procedures. Brit. J. Urol., 79: 414, 1997.
13. Jewett, M. A. S., Valiquette, L., Katz, J., Fradet, Y., Redelmeier, D. A. and Sampson, H. A.: Electromotive drug administration (EMDA) of lidocaine as an alternative anesthesia for transurethral surgery. J. Urol., part 2, 157: 273, abstract 1059, 1997.
14. Fontanella, U. A., Rossi, C. A. and Stephen, R. L.: Iontophoretic local anesthesia for bladder dilatation in the treatment of interstitial cystitis. Brit. J. Urol., 69: 662, 1992.
15. Riedl, C. R., Knoll, M. and Pflüger, H.: Electromotive drug administration and hydrodistension for the treatment of interstitial cystitis. Unpublished data.
16. Sant, G. R. and LaRock, D. R.: Standard intravesical therapies for interstitial cystitis. Urol. Clin. N. Amer., 21: 73, 1994.
17. Hanno, P. M. and Wein, A. J.: Conservative therapy of interstitial cystitis. Sem. Urol., 9: 143, 1991.
18. Huland, H. and Otto, U.: Mitomycin C instillation to prevent recurrence of superficial bladder carcinoma. Results of a controlled, prospective study in 58 patients. Eur. Urol., 9: 84, 1983.
19. Tolley, D. A., Hargreave, T. B., Smith, P. H., Williams, J. L., Grigor, K. M., Parmar, M. K. B., Freedman, L. S. and Uscinska, B. M.: Effect of intravesical MMC on recurrence of newly diagnosed superficial bladder cancer: interim report from the Medical Research Council Subgroup on Superficial Bladder Cancer (Urological Cancer Working Party). Brit. Med. J., 296: 1759, 1988.
20. Lundholm, C., Norlén, B. J., Ekman, P., Jahnson, S., Lagerkvist, M., Lindeborg, T., Olsson, J. O., Tveter, K., Wijkström, H., Westberg, R. and Malmström, P.: A randomized prospective study comparing long-term intravesical instillations of mitomycin C and bacillus Calmette-Guerin in patients with superficial bladder carcinoma. J. Urol., 156: 372, 1996.
21. Weese, D. L., Roskamp, D. A., Leach, G. E. and Zimmern, P. E.: Intravesical oxybutynin chloride: experience with 42 patients. Urology, 41: 527, 1993.
22. Pavlakis, A. J., Siroky, M. B. and Krane, R. J.: Neurogenic detrusor areflexia: correlation of perineal electromyographia and betanechol chloride supersensitivity test. J. Urol., 129: 1182, 1983.