메뉴 건너뛰기




Volumn 4, Issue 4, 1998, Pages 361-375

Animal model of brain aging: Senescence-accelerated mouse (SAM)

Author keywords

Anxiety; Behavioral depression; Circadian rhythm; Emotional behavior; Learning and memory; Oxidative stress; SAMP10; SAMP8; Senescence accelerated mouse

Indexed keywords

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; BRAIN FUNCTION; CIRCADIAN RHYTHM; CONTROLLED STUDY; EMOTION; INBRED STRAIN; LEARNING; MEMORY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PASSIVE AVOIDANCE; REVIEW; SENESCENCE; TASK PERFORMANCE;

EID: 0032445560     PISSN: 1080563X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3458.1998.tb00076.x     Document Type: Review
Times cited : (12)

References (71)
  • 1
    • 0027969281 scopus 로고
    • Defects of immune cells in the senescence-accelerated mouse: A model for learning and memory deficits in the aged
    • Abe Y, Yuasa M, Kajiwara Y, et al. Defects of immune cells in the senescence-accelerated mouse: A model for learning and memory deficits in the aged. Cell Immunol 1994;157:59-69.
    • (1994) Cell Immunol , vol.157 , pp. 59-69
    • Abe, Y.1    Yuasa, M.2    Kajiwara, Y.3
  • 2
    • 0022869476 scopus 로고
    • Periodic acid-Schiff (PAS)-positive, granular structures increase in the brain of senescence-accelerated mouse (SAM)
    • Akiyama H, Kameyama K, Akiguchi I, et al. Periodic acid-Schiff (PAS)-positive, granular structures increase in the brain of senescence-accelerated mouse (SAM). Acta Neuropathol 1986;72:124-129.
    • (1986) Acta Neuropathol , vol.72 , pp. 124-129
    • Akiyama, H.1    Kameyama, K.2    Akiguchi, I.3
  • 3
    • 0029125857 scopus 로고
    • Aging, energy, and oxidative stress in neurodegenerative diseases
    • Beal MF. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 1995;38:357-366.
    • (1995) Ann Neurol , vol.38 , pp. 357-366
    • Beal, M.F.1
  • 4
    • 0031029393 scopus 로고    scopus 로고
    • Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-α-phenylnitrone
    • Butterfield DA, Howard BJ, Yatin S, et al. Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-α-phenylnitrone. Proc Natl Acad Sci USA 1997;94:674-678.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 674-678
    • Butterfield, D.A.1    Howard, B.J.2    Yatin, S.3
  • 5
    • 0024432917 scopus 로고
    • Age-related changes in the temporomandibular joint of the senescence-accelerated mouse (SAM) SAM-P/3 as a new murine model of degenerative joint disease
    • Chen WHM, Hosokawa M, Tsuboyama T, et al. Age-related changes in the temporomandibular joint of the senescence-accelerated mouse (SAM) SAM-P/3 as a new murine model of degenerative joint disease. Am J Pathol 1989;135:379-387.
    • (1989) Am J Pathol , vol.135 , pp. 379-387
    • Chen, W.H.M.1    Hosokawa, M.2    Tsuboyama, T.3
  • 6
    • 0027536961 scopus 로고
    • Phase-shifting mechanisms in the mammalian arcadian system: New light on the carbachol paradox
    • Colwell CS, Kaufman CM, Menaker M. Phase-shifting mechanisms in the mammalian arcadian system: New light on the carbachol paradox. J Neurosci 1993;13:1454-1459.
    • (1993) J Neurosci , vol.13 , pp. 1454-1459
    • Colwell, C.S.1    Kaufman, C.M.2    Menaker, M.3
  • 7
    • 0029058728 scopus 로고
    • The spin-trap N-tert-α-phenyl-butylnitrone prolongs the life span of the senescence accelerated mouse
    • Edamatsu R, Mori A, Packer L. The spin-trap N-tert-α-phenyl-butylnitrone prolongs the life span of the senescence accelerated mouse. Biochem Biophys Res Commun 1995;211:847-849.
    • (1995) Biochem Biophys Res Commun , vol.211 , pp. 847-849
    • Edamatsu, R.1    Mori, A.2    Packer, L.3
  • 8
    • 0026575905 scopus 로고
    • Early onset of age-related impairment of aversive and appetitive learning in the SAM-P/8 mouse
    • Flood JF, Merely JE. Early onset of age-related impairment of aversive and appetitive learning in the SAM-P/8 mouse. J Gerontol 1992;47:B52-B59.
    • (1992) J Gerontol , vol.47
    • Flood, J.F.1    Merely, J.E.2
  • 9
    • 0027476481 scopus 로고
    • Age-related changes in footshock avoidance acquisition and retention in senescence accelerated mouse (SAM)
    • Flood JF, Morley JE. Age-related changes in footshock avoidance acquisition and retention in senescence accelerated mouse (SAM). Neurobiol Aging 1993;14:153-157.
    • (1993) Neurobiol Aging , vol.14 , pp. 153-157
    • Flood, J.F.1    Morley, J.E.2
  • 10
    • 0027410175 scopus 로고
    • Age-related changes in the pharmacological involvement of retention in senescence accelerated mouse (SAM)
    • Flood JF, Merely JE, La Reginna M. Age-related changes in the pharmacological involvement of retention in senescence accelerated mouse (SAM). Neurobiol Aging 1993;14:159-166.
    • (1993) Neurobiol Aging , vol.14 , pp. 159-166
    • Flood, J.F.1    Merely, J.E.2    La Reginna, M.3
  • 11
    • 0032566721 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions under conditions of oxidative stress as aging-related abnormalities in the brain of senescence accelerated mouse
    • Fujibayashi Y, Yamamoto S, Waki A, et al. Mitochondrial DNA deletions under conditions of oxidative stress as aging-related abnormalities in the brain of senescence accelerated mouse. Neurosci Lett 1998;254:109-112.
    • (1998) Neurosci Lett , vol.254 , pp. 109-112
    • Fujibayashi, Y.1    Yamamoto, S.2    Waki, A.3
  • 12
    • 0031926483 scopus 로고    scopus 로고
    • Age-related changes in blood pressure in the senescence-accelerated mouse (SAM): Aged SAMP1 mice manifest hypertensive vascular disease
    • Han J, Hosokawa M, Umezawa M, et al. Age-related changes in blood pressure in the senescence-accelerated mouse (SAM): Aged SAMP1 mice manifest hypertensive vascular disease. Lab Anim Sci 1998;48:256-263.
    • (1998) Lab Anim Sci , vol.48 , pp. 256-263
    • Han, J.1    Hosokawa, M.2    Umezawa, M.3
  • 13
    • 0028223426 scopus 로고
    • Free-radical theory of aging: Increasing the functional life span
    • Harman D. Free-radical theory of aging: Increasing the functional life span. Ann NY Acad Sci 1994;717:1-15.
    • (1994) Ann NY Acad Sci , vol.717 , pp. 1-15
    • Harman, D.1
  • 14
    • 0023024888 scopus 로고
    • SAM is an apoA-II apolipoprotein of mouse high density apolipoproteins
    • SAM is an apoA-II apolipoprotein of mouse high density apolipoproteins. J Biol Chem 1986;261:12834-12840.
    • (1986) J Biol Chem , vol.261 , pp. 12834-12840
    • Higuchi, K.1    Yonezu, T.2    Kogishi, K.3
  • 15
    • 0026052592 scopus 로고
    • Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice: Relationship between the molecular type of apoA-II and mouse senile amyloidosis
    • Higuchi K, Kitagawa K, Naiki H, et al. Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice: Relationship between the molecular type of apoA-II and mouse senile amyloidosis. Biochem J 1991;279:427-433.
    • (1991) Biochem J , vol.279 , pp. 427-433
    • Higuchi, K.1    Kitagawa, K.2    Naiki, H.3
  • 16
    • 0343471557 scopus 로고    scopus 로고
    • Management and design of the maintenance of SAM mouse strains: An animal model for accelerated senescence and age-associated disorders
    • Hosokawa M, Abe T, Higuchi K, et al. Management and design of the maintenance of SAM mouse strains: An animal model for accelerated senescence and age-associated disorders. Exp Gerontol 1997;32:111-116.
    • (1997) Exp Gerontol , vol.32 , pp. 111-116
    • Hosokawa, M.1    Abe, T.2    Higuchi, K.3
  • 17
    • 0023718745 scopus 로고
    • Cataract in senescence accelerated mouse (SAM). 2. Development of a new strain of mouse with late-appearing cataract
    • Hosokawa M, Ashida Y, Tsuboyama T, et al. Cataract in senescence accelerated mouse (SAM). 2. Development of a new strain of mouse with late-appearing cataract. Exp Eye Res 1988;47:629-640.
    • (1988) Exp Eye Res , vol.47 , pp. 629-640
    • Hosokawa, M.1    Ashida, Y.2    Tsuboyama, T.3
  • 18
    • 0023468886 scopus 로고
    • Immune responses in newly developed short-lived SAM mice. I. Age-associated early decline in immune activities of cultured spleen cells
    • Hosokawa M, Hosono M, Higuchi K, et al. Immune responses in newly developed short-lived SAM mice. I. Age-associated early decline in immune activities of cultured spleen cells. Immunology 1987;625:419-423.
    • (1987) Immunology , vol.625 , pp. 419-423
    • Hosokawa, M.1    Hosono, M.2    Higuchi, K.3
  • 19
    • 0023465996 scopus 로고
    • Immune responses in newly developed short-lived SAM mice. II. Selectivity impaired T-helper cell activity in in vivo antibody response
    • Hosokawa M, Hosono M, Hanada K, et al. Immune responses in newly developed short-lived SAM mice. II. Selectivity impaired T-helper cell activity in in vivo antibody response. Immunology 1987;625:424-429.
    • (1987) Immunology , vol.625 , pp. 424-429
    • Hosokawa, M.1    Hosono, M.2    Hanada, K.3
  • 20
    • 0020444391 scopus 로고
    • Effects of age and stress on regional noradrenaline metabolism in the brain
    • Ida Y, Tanaka M, Kohno Y, et al. Effects of age and stress on regional noradrenaline metabolism in the brain. Neurobiol Aging 1982;3:233-236.
    • (1982) Neurobiol Aging , vol.3 , pp. 233-236
    • Ida, Y.1    Tanaka, M.2    Kohno, Y.3
  • 21
    • 0022385403 scopus 로고
    • Attenuating effect of diazepam on stress-induced increases in noradrenaline turnover in specific brain regions of rats. Antagonism by Ro 15-1788
    • Ida Y, Tanaka M, Tsuda A, et al. Attenuating effect of diazepam on stress-induced increases in noradrenaline turnover in specific brain regions of rats. Antagonism by Ro 15-1788. Life Sci 1985;37:2491-2498.
    • (1985) Life Sci , vol.37 , pp. 2491-2498
    • Ida, Y.1    Tanaka, M.2    Tsuda, A.3
  • 22
    • 0020286904 scopus 로고
    • Circadian rhythmicity and sleep: Effects of aging in laboratory animals
    • Ingram DK, London ED, Reynolds MA. Circadian rhythmicity and sleep: Effects of aging in laboratory animals. Neurobiol Aging 1982;3:287-297.
    • (1982) Neurobiol Aging , vol.3 , pp. 287-297
    • Ingram, D.K.1    London, E.D.2    Reynolds, M.A.3
  • 23
    • 0029928698 scopus 로고    scopus 로고
    • Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence
    • Jilka RL, Weinstein RS, Takahashi K, et al. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. J Clin Invest 1996;97:1732-1740.
    • (1996) J Clin Invest , vol.97 , pp. 1732-1740
    • Jilka, R.L.1    Weinstein, R.S.2    Takahashi, K.3
  • 24
    • 0024330780 scopus 로고
    • 3H]nitrendipine to cerebral cortical and hippocampal membranes of senescence accelerated mouse
    • 3H]nitrendipine to cerebral cortical and hippocampal membranes of senescence accelerated mouse. Neurosci Lett 1989;106:334-338.
    • (1989) Neurosci Lett , vol.106 , pp. 334-338
    • Kitamura, Y.1    Zhao, X.H.2    Ohnuki, T.3    Nomura, Y.4
  • 25
    • 0028208836 scopus 로고
    • Age-related changes in lung structure and function in the senescence-accelerated mouse (SAM): SAM-P/1 as new murine model of senile hyperinflation
    • Kurozumi M, Matsushita M, Hosokawa M, et al. Age-related changes in lung structure and function in the senescence-accelerated mouse (SAM): SAM-P/1 as new murine model of senile hyperinflation. Am J Respir Crit Care Med 1994;149:776-782.
    • (1994) Am J Respir Crit Care Med , vol.149 , pp. 776-782
    • Kurozumi, M.1    Matsushita, M.2    Hosokawa, M.3
  • 26
    • 0031858787 scopus 로고    scopus 로고
    • Behavioral assessment of senescence-accelerated mouse (SAMP8 and R1)
    • Markowska A, Spangler EL, Ingram DK. Behavioral assessment of senescence-accelerated mouse (SAMP8 and R1). Physiol Behav 1998;64:15-26.
    • (1998) Physiol Behav , vol.64 , pp. 15-26
    • Markowska, A.1    Spangler, E.L.2    Ingram, D.K.3
  • 27
    • 0022966848 scopus 로고    scopus 로고
    • Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis
    • Matsushita M, Tsuboyama R, Kasai R, et al. Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis. Am J Pathol 1996;215:276-283.
    • (1996) Am J Pathol , vol.215 , pp. 276-283
    • Matsushita, M.1    Tsuboyama, R.2    Kasai, R.3
  • 28
    • 0024381083 scopus 로고
    • The neurophysiology of the suprachiasmatic circadian pacemaker in rodents
    • Meijer JH, Rietveld WJ. The neurophysiology of the suprachiasmatic circadian pacemaker in rodents. Physiol Rev 1989;69:671-708.
    • (1989) Physiol Rev , vol.69 , pp. 671-708
    • Meijer, J.H.1    Rietveld, W.J.2
  • 29
    • 0028013332 scopus 로고
    • Morning bright light therapy for sleep and behavior disorders in elderly patients with dementia
    • Mishima K, Okawa M, Hishikawa Y, et al. Morning bright light therapy for sleep and behavior disorders in elderly patients with dementia. Acta Psychiatr Scand 1994;89:1-7.
    • (1994) Acta Psychiatr Scand , vol.89 , pp. 1-7
    • Mishima, K.1    Okawa, M.2    Hishikawa, Y.3
  • 30
    • 0002729907 scopus 로고
    • Characteristics of memory and behavioral disorders in SAMP8 mice
    • Takeda T, ed. Amsterdam: Elsevier
    • Miyamoto M. Characteristics of memory and behavioral disorders in SAMP8 mice. In: Takeda T, ed. The SAM model of Senescence. Amsterdam: Elsevier, 1994;61-66.
    • (1994) The SAM Model of Senescence , pp. 61-66
    • Miyamoto, M.1
  • 31
    • 0030896788 scopus 로고    scopus 로고
    • Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10
    • Miyamoto M. Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10. Exp Gerontol 1997;32:139-148.
    • (1997) Exp Gerontol , vol.32 , pp. 139-148
    • Miyamoto, M.1
  • 32
    • 0026692163 scopus 로고
    • Senescence-accelerated mouse (SAM): Age-related reduced anxiety-like behavior in the SAM-P/8 strain
    • Miyamoto M, Kiyota Y, Nishiyama M, Nagaoka A. Senescence-accelerated mouse (SAM): Age-related reduced anxiety-like behavior in the SAM-P/8 strain. Physiol Behav 1992;51:979-985.
    • (1992) Physiol Behav , vol.51 , pp. 979-985
    • Miyamoto, M.1    Kiyota, Y.2    Nishiyama, M.3    Nagaoka, A.4
  • 33
    • 0022970786 scopus 로고
    • Age-related changes in learning and memory in the senescence-accelerated mouse (SAM)
    • Miyamoto M, Kiyota Y, Yamazaki N, et al. Age-related changes in learning and memory in the senescence-accelerated mouse (SAM). Physiol Behav 1986;38:399-406.
    • (1986) Physiol Behav , vol.38 , pp. 399-406
    • Miyamoto, M.1    Kiyota, Y.2    Yamazaki, N.3
  • 34
    • 0028596022 scopus 로고
    • Prolongation of life span and improved learning in the senescence accelerated mouse produced by aged garlic extract
    • Moriguchi T, Takashina K, Chu P-J, et al. Prolongation of life span and improved learning in the senescence accelerated mouse produced by aged garlic extract. Biol Pharm Bull 1994;17:1589-1594.
    • (1994) Biol Pharm Bull , vol.17 , pp. 1589-1594
    • Moriguchi, T.1    Takashina, K.2    Chu, P.-J.3
  • 35
    • 0028804767 scopus 로고
    • Monoamine oxidase-B-positive granular structures in the hippocampus of aged senescence-accelerated mouse (SAMP8)
    • Nakamura S, Akiguchi I, Seriu N, et al. Monoamine oxidase-B-positive granular structures in the hippocampus of aged senescence-accelerated mouse (SAMP8). Acta Neuropathol 1995;90:626-632.
    • (1995) Acta Neuropathol , vol.90 , pp. 626-632
    • Nakamura, S.1    Akiguchi, I.2    Seriu, N.3
  • 36
    • 0342526274 scopus 로고
    • Senescence-accelerated mouse (SAMP8): An animal model for age-related circadian rhythm disorder
    • Takeda T, ed. Amsterdam: Elsevier
    • Nishiyama M, Takahashi H, Miyamoto M. Senescence-accelerated mouse (SAMP8): An animal model for age-related circadian rhythm disorder. In: Takeda T, ed. The SAM Model of Senescence. Amsterdam: Elsevier, 1994;393-396.
    • (1994) The SAM Model of Senescence , pp. 393-396
    • Nishiyama, M.1    Takahashi, H.2    Miyamoto, M.3
  • 37
    • 0027970715 scopus 로고
    • Ameliorative effects of chronic treatment using DX9386, a traditional Chinese prescription, on learning performance and lipid peroxide content in senescence accelerated mouse
    • Nishiyama N, Zhou Y, Saito H. Ameliorative effects of chronic treatment using DX9386, a traditional Chinese prescription, on learning performance and lipid peroxide content in senescence accelerated mouse. Biol Pharm Bull 1994;17:1481-1484.
    • (1994) Biol Pharm Bull , vol.17 , pp. 1481-1484
    • Nishiyama, N.1    Zhou, Y.2    Saito, H.3
  • 38
    • 0024529369 scopus 로고
    • Biochemical changes related to aging in the senescence accelerated mouse
    • Nomura Y, Wang B-X, Qi S-B, et al. Biochemical changes related to aging in the senescence accelerated mouse. Exp Gerontol 1989;24:49-55.
    • (1989) Exp Gerontol , vol.24 , pp. 49-55
    • Nomura, Y.1    Wang, B.-X.2    Qi, S.-B.3
  • 39
    • 0024434242 scopus 로고
    • Behavioral characteristics of the SAM-P/8 strain in Sidman active avoidance task
    • Ohta A, Hirano T, Yagi H, et al. Behavioral characteristics of the SAM-P/8 strain in Sidman active avoidance task. Brain Res 1989;498:195-198.
    • (1989) Brain Res , vol.498 , pp. 195-198
    • Ohta, A.1    Hirano, T.2    Yagi, H.3
  • 40
    • 0029806047 scopus 로고    scopus 로고
    • Relationship of impaired brain glucose metabolism to learning deficit in the senescence-accelerated mouse
    • Ohta H, Nishikawa H, Hirai K, et al. Relationship of impaired brain glucose metabolism to learning deficit in the senescence-accelerated mouse. Neurosci Lett 1996;217:37-40.
    • (1996) Neurosci Lett , vol.217 , pp. 37-40
    • Ohta, H.1    Nishikawa, H.2    Hirai, K.3
  • 41
    • 0029741622 scopus 로고    scopus 로고
    • Protection against impairment of memory and immunoreactivity in senescence-accelerated mice by acidic fibroblast growth factor
    • Oomura Y, Sasaki K, Li A, et al. Protection against impairment of memory and immunoreactivity in senescence-accelerated mice by acidic fibroblast growth factor. Ann NY Acad Sci 1996;786:337-347.
    • (1996) Ann NY Acad Sci , vol.786 , pp. 337-347
    • Oomura, Y.1    Sasaki, K.2    Li, A.3
  • 43
    • 0022374863 scopus 로고
    • Validation of open closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
    • Pellow S, Chopin P, File SE, Briley M. Validation of open closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. Neurosci Methods 1985;14:149-165.
    • (1985) Neurosci Methods , vol.14 , pp. 149-165
    • Pellow, S.1    Chopin, P.2    File, S.E.3    Briley, M.4
  • 44
    • 0022620470 scopus 로고
    • Anxiolytic and anxiogenic drug effects in exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat
    • Pellow S, File SE. Anxiolytic and anxiogenic drug effects in exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat. Pharmacol Biochem Behav 1987;24:525-529.
    • (1987) Pharmacol Biochem Behav , vol.24 , pp. 525-529
    • Pellow, S.1    File, S.E.2
  • 45
    • 0027298509 scopus 로고
    • Monoamine depletion alters the entrainment and the response to light of circadian activity rhythm in hamsters
    • Penev PD, Turk FW, Zee PC. Monoamine depletion alters the entrainment and the response to light of circadian activity rhythm in hamsters. Brain Res 1993;612:156-164.
    • (1993) Brain Res , vol.612 , pp. 156-164
    • Penev, P.D.1    Turk, F.W.2    Zee, P.C.3
  • 46
    • 0032229327 scopus 로고    scopus 로고
    • Reactive oxygen species mediate cellular damage in Alzheimer disease
    • Perry G, Castellani RJ, Hirai K, Smith MA. Reactive oxygen species mediate cellular damage in Alzheimer disease. J Alzheim Dis 1998;1:45-55.
    • (1998) J Alzheim Dis , vol.1 , pp. 45-55
    • Perry, G.1    Castellani, R.J.2    Hirai, K.3    Smith, M.A.4
  • 47
    • 0343052684 scopus 로고    scopus 로고
    • Differences between the circadian rhythm of two strains of senescence-accelerated mice (SAM)
    • Sáchez-Barceló EJ, Magias M, Verduga R, Crespo D. Differences between the circadian rhythm of two strains of senescence-accelerated mice (SAM). Physiol Behav 1997;62:1225-1229.
    • (1997) Physiol Behav , vol.62 , pp. 1225-1229
    • Sáchez-Barceló, E.J.1    Magias, M.2    Verduga, R.3    Crespo, D.4
  • 48
    • 0028348987 scopus 로고
    • Age-related hearing impairment in senescence-accelerated mouse (SAM)
    • Saitoh Y, Hosokawa M, Shimada A, et al. Age-related hearing impairment in senescence-accelerated mouse (SAM). Hear Res 1994;75:27-37.
    • (1994) Hear Res , vol.75 , pp. 27-37
    • Saitoh, Y.1    Hosokawa, M.2    Shimada, A.3
  • 49
    • 0028970068 scopus 로고
    • Age-related cochlear degeneration in senescence-accelerated mouse
    • Saitoh Y, Hosokawa M, Shimada A, et al. Age-related cochlear degeneration in senescence-accelerated mouse. Neurobiol Aging 1995;16:129-136.
    • (1995) Neurobiol Aging , vol.16 , pp. 129-136
    • Saitoh, Y.1    Hosokawa, M.2    Shimada, A.3
  • 50
    • 0030032553 scopus 로고    scopus 로고
    • Early and transient increase in oxidative stress in the cerebral cortex of senescence-accelerated mouse
    • Sato E, Oda N, Ozaki N, et al. Early and transient increase in oxidative stress in the cerebral cortex of senescence-accelerated mouse. Mech Ageing Dev 1996;86:105-114.
    • (1996) Mech Ageing Dev , vol.86 , pp. 105-114
    • Sato, E.1    Oda, N.2    Ozaki, N.3
  • 51
    • 0026776419 scopus 로고
    • Inbred SAM-P/10 as a mouse model of spontaneous inherited brain atrophy
    • Shimada A, Ohta A, Akiguchi I, Takeda T. Inbred SAM-P/10 as a mouse model of spontaneous inherited brain atrophy. J Neuropathol Exp Neurol 1992;51:440-450.
    • (1992) J Neuropathol Exp Neurol , vol.51 , pp. 440-450
    • Shimada, A.1    Ohta, A.2    Akiguchi, I.3    Takeda, T.4
  • 52
    • 0027467103 scopus 로고
    • Age-related deterioration in conditional avoidance task in the SAM-P/10 mouse, an animal model of spontaneous brain atrophy
    • Shimada A, Ohta A, Akiguchi I, Takeda T. Age-related deterioration in conditional avoidance task in the SAM-P/10 mouse, an animal model of spontaneous brain atrophy. Brain Res 1993;608:266-272.
    • (1993) Brain Res , vol.608 , pp. 266-272
    • Shimada, A.1    Ohta, A.2    Akiguchi, I.3    Takeda, T.4
  • 53
    • 0007627726 scopus 로고    scopus 로고
    • Oxidative stress in Alzheimer's
    • Smith MA, Perry G, Richey PL, et al. Oxidative stress in Alzheimer's. Nature 1996;382:120-121.
    • (1996) Nature , vol.382 , pp. 120-121
    • Smith, M.A.1    Perry, G.2    Richey, P.L.3
  • 54
    • 0021990491 scopus 로고
    • The tail suspension test: A new method for screening antidepressants in mice
    • Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology 1985;85:367-370.
    • (1985) Psychopharmacology , vol.85 , pp. 367-370
    • Steru, L.1    Chermat, R.2    Thierry, B.3    Simon, P.4
  • 55
    • 0008438681 scopus 로고
    • Effects of chronic administration of idebenone on age-related behavioral disorders in senescence-accelerated mice (SAMP8)
    • Takeda T, ed. Amsterdam: Elsevier
    • Takahashi H, Nishiyama M, Takami K, et al. Effects of chronic administration of idebenone on age-related behavioral disorders in senescence-accelerated mice (SAMP8). In: Takeda T, ed. The SAM model of senescence. Amsterdam: Elsevier, 1994;427-430.
    • (1994) The SAM Model of Senescence , pp. 427-430
    • Takahashi, H.1    Nishiyama, M.2    Takami, K.3
  • 56
    • 0025938219 scopus 로고
    • Senescence-accelerated mouse (SAM): A novel murine model of accelerated senescence
    • Takeda T, Hosokawa M, Higuchi K. Senescence-accelerated mouse (SAM): A novel murine model of accelerated senescence. J Am Geriatr Soc 1991;39:911-919.
    • (1991) J Am Geriatr Soc , vol.39 , pp. 911-919
    • Takeda, T.1    Hosokawa, M.2    Higuchi, K.3
  • 57
    • 0030896787 scopus 로고    scopus 로고
    • Senescence-accelerated mouse (SAM): A novel murine model of senescence
    • Takeda T, Hosokawa M, Higuchi K. Senescence-accelerated mouse (SAM): A novel murine model of senescence. Exp Gerontol 1997;32:105-109.
    • (1997) Exp Gerontol , vol.32 , pp. 105-109
    • Takeda, T.1    Hosokawa, M.2    Higuchi, K.3
  • 58
    • 0002904277 scopus 로고
    • Senescence-accelerated mouse (SAM). A novel murine model of aging
    • Takeda T, ed. Amsterdam: Elsevier
    • Takeda T, Hosokawa M, Higuchi K. Senescence-accelerated mouse (SAM). A novel murine model of aging. In: Takeda T, ed. The SAM model of senescence. Amsterdam: Elsevier, 1994;15-22.
    • (1994) The SAM Model of Senescence , pp. 15-22
    • Takeda, T.1    Hosokawa, M.2    Higuchi, K.3
  • 59
    • 0019850002 scopus 로고
    • A new murine model of accelerated senescence
    • Takeda T, Hosokawa M, Takeshita S, et al. A new murine model of accelerated senescence. Mech Ageing Dev 1981;17:183-194.
    • (1981) Mech Ageing Dev , vol.17 , pp. 183-194
    • Takeda, T.1    Hosokawa, M.2    Takeshita, S.3
  • 60
    • 0030899547 scopus 로고    scopus 로고
    • Pathobiology of the senescence-accelerated mouse (SAM)
    • Takeda T, Matsushita T, Kurozumi M, et al. Pathobiology of the senescence-accelerated mouse (SAM). Exp Gerontol 1997;32:117-127.
    • (1997) Exp Gerontol , vol.32 , pp. 117-127
    • Takeda, T.1    Matsushita, T.2    Kurozumi, M.3
  • 61
    • 0026724511 scopus 로고
    • Age-related changes in GSH content of eyes in mice - A comparison of senescence-accelerated mouse (SAM) and C57BL/J mice
    • Teramoto S, Fukuchi Y, Uejima X, et al. Age-related changes in GSH content of eyes in mice - A comparison of senescence-accelerated mouse (SAM) and C57BL/J mice. Comp Biochem Physiol 1992;102A:693-696.
    • (1992) Comp Biochem Physiol , vol.102 A , pp. 693-696
    • Teramoto, S.1    Fukuchi, Y.2    Uejima, X.3
  • 63
    • 0030917786 scopus 로고    scopus 로고
    • Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients
    • Van Someren EJW, Kessler A, Mirmiran M, Swaab DF. Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients. Biol Psychiatry 1997;41:955-963.
    • (1997) Biol Psychiatry , vol.41 , pp. 955-963
    • Van Someren, E.J.W.1    Kessler, A.2    Mirmiran, M.3    Swaab, D.F.4
  • 64
    • 0027742807 scopus 로고
    • Non-pharmacological treatment of sleep and wake disturbances in aging and Alzheimer's disease: Chronological perspectives
    • Van Someren EJW, Mirmiran M, Swaab DF. Non-pharmacological treatment of sleep and wake disturbances in aging and Alzheimer's disease: Chronological perspectives. Behav Brain Res 1993;57:235-253.
    • (1993) Behav Brain Res , vol.57 , pp. 235-253
    • Van Someren, E.J.W.1    Mirmiran, M.2    Swaab, D.F.3
  • 65
    • 0015004136 scopus 로고
    • A simple and reliable conflict procedure for testing antianxiety agents
    • Vogel JR, Beer B, Clody DE. A simple and reliable conflict procedure for testing antianxiety agents. Psychopharmacologia 1971;4:1-7.
    • (1971) Psychopharmacologia , vol.4 , pp. 1-7
    • Vogel, J.R.1    Beer, B.2    Clody, D.E.3
  • 66
    • 0030049009 scopus 로고    scopus 로고
    • Efficiency and safety of idebenone in the long-term treatment of Alzheimer's disease: A double-blind, placebo controlled multicentre study
    • Weyer G, Erzigkeit H, Hadler D, Kubicki S. Efficiency and safety of idebenone in the long-term treatment of Alzheimer's disease: A double-blind, placebo controlled multicentre study. Human Psychopharmacol 1996;11:53-65.
    • (1996) Human Psychopharmacol , vol.11 , pp. 53-65
    • Weyer, G.1    Erzigkeit, H.2    Hadler, D.3    Kubicki, S.4
  • 67
    • 0032571747 scopus 로고    scopus 로고
    • Spontaneous and artificial lesions of magnocellular reticular formation of brainstem deteriorate avoidance learning in senescence-accelerated mouse SAM
    • Yagi H, Akiguchi I, Ohta A, et al. Spontaneous and artificial lesions of magnocellular reticular formation of brainstem deteriorate avoidance learning in senescence-accelerated mouse SAM. Brain Res 1998;791:90-98.
    • (1998) Brain Res , vol.791 , pp. 90-98
    • Yagi, H.1    Akiguchi, I.2    Ohta, A.3
  • 68
    • 0024211998 scopus 로고
    • Age-related deterioration of abnormality of acquisition in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbances in recent memory
    • Yagi H, Katoh I, Akiguchi I, et al. Age-related deterioration of abnormality of acquisition in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbances in recent memory. Brain Res 1988;474:86-93.
    • (1988) Brain Res , vol.474 , pp. 86-93
    • Yagi, H.1    Katoh, I.2    Akiguchi, I.3
  • 69
    • 85044550156 scopus 로고
    • Spontaneous spongy degeneration of the brainstem in SAM-P/8 mice, a newly developed memory-deficient strain
    • Yagi H, Irino M, Matsushita M, et al. Spontaneous spongy degeneration of the brainstem in SAM-P/8 mice, a newly developed memory-deficient strain. J Neuropathol Exp Neurol 1989;48:577-590.
    • (1989) J Neuropathol Exp Neurol , vol.48 , pp. 577-590
    • Yagi, H.1    Irino, M.2    Matsushita, M.3
  • 70
    • 0026496496 scopus 로고
    • Effects of aging on entrainment and rate of resynchronization of circadian locomotor activity
    • Zee PC, Rosenberg RS, Turek FW. Effects of aging on entrainment and rate of resynchronization of circadian locomotor activity. Am J Physiol 1992;263:R1099-R1103.
    • (1992) Am J Physiol , vol.263
    • Zee, P.C.1    Rosenberg, R.S.2    Turek, F.W.3
  • 71
    • 0024997585 scopus 로고
    • 3H]noradrenaline in brain slices of senescence accelerated mouse
    • 3H]noradrenaline in brain slices of senescence accelerated mouse. Int J Dev Neurosci 1990;8:267-272.
    • (1990) Int J Dev Neurosci , vol.8 , pp. 267-272
    • Zhao, X.H.1    Nomura, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.