Concentrations of anesthetics across the water-membrane interface; the Meyer-Overton hypothesis revisited

Toxicology Letters

Volumn 100-101, Issue , 1998, Pages 421-430

  Pohorille, Andrew ^a,b   Wilson, Michael A ^a,b   New, Michael H ^a,b   Chipot, Christophe ^a,c  

^a NASA AMES RESEARCH CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Free energy; Mechanism of anesthetic action; Meyer Overton relation; Water membrane interface; Water oil interface

Indexed keywords

ALCOHOL; ALKANE; ALKANOL; ANESTHETIC AGENT; ANESTHETIC GAS; ARGON; BUTANE; BUTANOL; CARBON TETRACHLORIDE; CYCLOBUTANE; CYCLOPROPANE; DESFLURANE; ENFLURANE; FLUOROMETHANE; HEXANOL; ISOFLURANE; KRYPTON; METHANE; METHANOL; NITROUS OXIDE; OCTANOL; XENON;

CONFERENCE PAPER; DRUG MECHANISM; DRUG POTENCY; HYPOTHESIS; LIPID SOLUBILITY; MEMBRANE TRANSPORT; PRIORITY JOURNAL;

NASA CENTER ARC; NASA DISCIPLINE EXOBIOLOGY;

ALGORITHMS; ANESTHETICS; CHEMISTRY, PHYSICAL; COMPUTER SIMULATION; LIPIDS; MEMBRANES, ARTIFICIAL; OILS; SOLUBILITY; WATER;

EID: 0032445164     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00216-1     Document Type: Conference Paper

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