Positive inotropic, negative chronotropic, and coronary vasoconstrictor effects of acetylcholine in isolated rat hearts: Role of muscarinic receptors, prostaglandins, protein kinase C, influx of extracellular Ca2+, intracellular Ca2+ release, and endothelium

Japanese Journal of Physiology

Volumn 48, Issue 6, 1998, Pages 483-491

  Ateş, Sadiye ^a   Kaygisiz, Ziya ^a  

^a ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

Author keywords

Acetylcholine; Coronary flow; Heart rate; Isolated perfused rat heart; Myocardial contractility

Indexed keywords

ACETYLCHOLINE; CALCIUM ION; MUSCARINIC RECEPTOR; NITRIC OXIDE; PROSTAGLANDIN; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CALCIUM TRANSPORT; CHRONOTROPISM; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CONSTRICTION; FEMALE; HEART CONTRACTION; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE PERFUSION; HEART RATE; INOTROPISM; MALE; NONHUMAN; PERFUSION PRESSURE; RAT; VASCULAR ENDOTHELIUM;

EID: 0032443961     PISSN: 0021521X     EISSN: None     Source Type: Journal    
DOI: 10.2170/jjphysiol.48.483     Document Type: Article

References (30)

1. Furchgott RF and Zawadzki JV: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376, 1980
2. Cherry PD, Furchgott RF, Zawadzki JV, and Jothianandan D: The role of endothelial cells in the relaxation of isolated arteries by bradykinin. Proc Natl Acad Sci USA 79: 2105-2110, 1982
3. Furchgott RF: Role of the endothelium in responses of vascular smooth muscle. Giro Res 53: 557-573, 1983
4. Furchgott RF and Vanhoutte PM: Endothelium derived relaxing and contracting factors. FASEB J 3: 2007-2018, 1989
5. Kalsner S: Cholinergic mechanisms in human coronary artery preparations : implications of species differences. J Physiol (Lond) 358 : 509-526, 1985
6. Akahane K, Furukawa Y, Ogiwara Y, Itaniuda M, Takeda M, and Chiba S: Pharmacological analysis of chorono- and inotropic responses to diazepem in the isolated blood perfused canine atrium. Arch Int Pharmacodyn Ther 290: 173-184, 1987
7. Chiba S, Karasawa Y, Adahane K, and Ken LM: Pharmacological analysis of cardiac effects of a central cholinergic agent, WEB 1881-FU, in isolated canine heart preparations. Jpn Heart J 290: 173-184, 1990
8. Jeck D, Lindmar R, Loffeholz K, and Wanke M: Subtypes of muscarinic receptor on cholinergic nerves and atrial cells of chicken and guinea pig hearts. Br J Pharmacol 93: 357-366, 1988
9. Ogiwara Y, Furukawa Y, Takeda M, and Chiba S: Blocking effects of alinidine on negative chronotropic and inotropic responses to vagal stimulation and injected acetylcholine and carbachol in dogs. J Pharmacol Exp Ther 243: 1113-1120, 1987
10. Hohl CM and Hearse DJ: Vascular and contractile response to extracellular ATP: studies in the isolated rat heart. Can J Cardiol 1: 207-216, 1985
11. Karakulluçku YE, Ozçelik T, and Gökhan N: Changes in cyclic nucleotides during the calcium paradox in the isolated rat heart. Pflügers Arch 410: 657-663, 1987
12. Nakata T, Hearse DJ, and Curtis MJ: Are reperfusion-induced arrhytmias caused by disinhibition of an arrhytmogenic component of ischemia? J Mol Cell Cardiol 22: 843-858, 1990
13. Alpoim NC, Almedia AP, Santos PE, and Freira-Maia L: Oscillations of cardiac rate induced by acetylcholine in the isolated guinea pig heart. Braz J Med Biol Res 22: 87-96, 1989
14. Ozçelik T, Karakullukçu YE, Unal T, and Gökhan N: Positive inotropy seen following calcium-free, acetylcholine added perfusion in cardiac muscle of the rat. IRSC Med Sci 13: 128, 1985
15. Yang BC, Nichols WW, and Mehta JL: Cardiac effects of acetylcholine in rat hearts: role of endothelium-derived relaxing factor and prostaglandins. Am J Physiol 264: H1388-H1393, 1993
16. Tsuji Y, Tajima T, Yuen J, and Pappano AJ: Positive inotropic effects of acetylcholine and BY K 8644 in embryonic chick ventricle. Am J Physiol 252: H 807-H 815, 1987
17. Korth M and Kühlkamp V: Muscarinic receptors mediate negative and positive inotropic effects in mammalian ventricular myocardium: differentiation by agonists. Br J Pharmacol 90: 81-90, 1987
18. 2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-triphosphate. Biochem J 223: 229-236, 1984
19. 2+ from a non-mitochondrial intracellular store in pancreatic acinar cells by inositol 1,4,5-trisphosphate Nature 306 : 67-69, 1983
20. Volpe P, Salviati G, Di Virgilio F, and Pozzan T: Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum of sketal muscle. Nature 316: 347-349, 1985
21. Limas CJ: Calcium-binding sites in rat myocardial sarcolemma. Arch Biochim Biophys 179: 302-309, 1977
22. Canadian Council on Animal Care: Guide to the Care and Use of Experimental Animals, CCAC, Ottawa, Vol 2, pp 176-187, 1984
23. Neely JR, Libermeister H, Battersby EJ, and Morgan EH: Effect of pressure development on oxygen consumption by isolated rat hearts. Am J Physiol 212: 804-814, 1967
24. Langendorff O: Untersuchungen am überlebenden Säugetierherzen. Pflügers Arch 61: 291-332, 1895
25. George WJ, Wilkerson RD, and Kadowitz PJ: Influence of acetylcholine on contractile force and cyclic nucleotide levels in the isolated perfused rat heart. J Pharmacol Exp Ther 184 : 228-235, 1973
26. Gilmour RF Jr and Zipes DP: Positive inotropic effect of acetylcholine in canine cardiac purkinje fibers. Am J Physiol 249 : H735-H740, 1985
27. Ascuitto RJ, Ross-Ascuitto NT, Ramage D, McDonough KH, and Kadowitz PJ: Acetylcholine-induced coronary vasoconstriction and negative inotropy in the neonatal pig heart. Pediatr Res 32: 236-242, 1992
28. Corr L, Burnstock G, and Poole-Wilson P: Responses of the rabbit epicardial coronary artery to acetylcholine and adrenoceptor agonists. Cardiovasc Res 25: 256-262, 1991
29. Sakai K: Coronary vasoconstriction by locally administered acetylcholine, carbachol and bethanechol in isolated, donor-perfused, rat hearts. Br J Pharmacol 68: 625-632, 1980
30. Stewart AG and Piper PJ: Vasodilator actions of acetylcholine, A 23187 and bradykinin in the guinea-pig isolated perfused heart are independent of prostacyclin. Br J Pharmacol 95: 379-384, 1988