Analysis of allelic association between D6S461 marker and multiple sclerosis in Ashkenazi and Iraqi Jewish patients

Journal of Molecular Neuroscience

Volumn 11, Issue 3, 1998, Pages 265-269

  Shinar, Yael ^a,d   Pras, Elon ^b   Siev Ner, Itzhak ^a   Gamus, Dorit ^a   Brautbar, Chaim ^c   Israel, Shoshana ^c   Achiron, Anat ^a  

^a SHEBA MEDICAL CENTER   (Israel)

^b GERTNER INSTITUTE FOR EPIDEMIOLOGY AND HEALTH POLICY RESEARCH   (Israel)

^c HEBREW UNIVERSITY   (Israel)

^d HELLER INSTITUTE OF MEDICAL RESEARCH   (Israel)

Author keywords

Allelic asociation; Ashkenazi; D6S461 genetic marker; Genetic susceptibility; Iraqi Jewish; Juvenile; Linkage disequilibrium; Multiple sclerosis; Population based study; Relapsing remitting

Indexed keywords

ALLELISM; ARTICLE; GENETIC LINKAGE; HUMAN; JEW; MARKER GENE; MULTIPLE SCLEROSIS; PATHOGENESIS; POLYMERASE CHAIN REACTION; RELAPSE;

ADOLESCENT; ADULT; AGE OF ONSET; ALLELES; EUROPE; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HUMANS; IRAQ; JEWS; LINKAGE DISEQUILIBRIUM; MATCHED-PAIR ANALYSIS; MULTIPLE SCLEROSIS;

EID: 0032443791     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:11:3:265     Document Type: Article

References (21)

1. Bacon K. B. (1997) Analysis of signal transduction following lymphocyte activation by chemokines. Methods Enzymol. 288, 340-361.
2. Barcellos L. F., Thomson G., Carrington M., Schafer J., Begovich A. B., Lin P., Xu X. H., Min B. Q., Marti D., and Klitz W. (1997) Chromosome 19 single locus and multilocus haplotype associations with multiple sclerosis: evidence of a new susceptibility locus in Caucasian and Chinese patients. JAMA 278, 1256-1261.
3. Bonné-Tamir B., Zoossmann-Diskin A., and Ticher A. (1992) Genetic diversity among Jews reexamined: preliminary analyses at the DNA level, in Genetic Diversity Among Jews: Diseases and Markers at the DNA Level (Bonné-Tamir B. and Adam A., eds.), Oxford University Press, New York, pp. 80-94.
4. Bundey S. (1996) Multiple sclerosis and other demyelinating disorders, in Principles and Practice of Medical Genetics (Remoin D. L., Connor J. M., and Pyeritz R. E., eds.), Churchill Livingstone, New York, pp. 2303-2311.
5. Dawson G., Dawson S. A., and Post G. R. (1993) Regulation of phospholipase D activity in a human oligodendroglioma cell line (HOG). J. Neurosci. Res. 34, 324-330.
6. Ebers G. C, Bulman E. D., Sadovnick A. D., Paty D. W., Warren S., Hader W., Murray T. J., Seland T. P., Duquette P., Grey T., et al. (1986) A population-based study of multiple sclerosis in twins. N. Engl. J. Med. 315, 1638-1642.
7. Ebers G. C., Kukay K., Bulman D. E., Sadovnick A. D., Rice G., Anderson C., Amstrong H., et al. (1996) A full genome search in multiple sclerosis. Nature Genetics 13, 472-476.
8. Ghezzi A., Deplano V., Faroni J., Grasso M. G., Liguori M., Marrosu G., Pozzilli C., Simone I. L., and Zaffaroni M. (1997) Multiple sclerosis in childhood: clinical features of 149 cases. Multiple Sclerosis 3, 43-46.
9. Haines J. L., ter-Minassian M., Bazyc A., Gusell F. J., et al. (1996) A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nature Genetics 13, 469-471.
10. Hillert J. and Olerup O. (1993) Multiple sclerosis is associated with genes within or close to the HLA-DR-DQ-subregion on a normal DR15,DQ6,Dw2 haplotype. Neurology 43, 163-168.
11. Jersild C., Dupont B., Fog T., et al. (1975) Histocompatibility determinants in multiple sclerosis. Transplant Rev. 22, 148-163.
12. Jorde L. B. (1995) Linkage disequilibrium as a gene-mapping tool. Am. J. Hum. Genet. 56, 11-14.
13. Kelly M. A., Cavan D. A., Penny M. A., et al. (1993) The influence of HLA-DR and -DQ alleles on progression to multiple sclerosis following a clinically isolated syndrome. Hum. Immunol. 37, 185-191.
14. Kuokkanen S., Sundvall M., Terwilliger J. D., Tienari P. J., Wikstrom J., Holmdahl R., Pettersson U., and Peltonen L. (1996) A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to murine locus Eae2. Nature Genet. 13, 477-480.
15. Min D. S., Park S. K., and Exton J. H. (1998) Characterization of a rat brain phopsholipase D isozyme. J. Biol. Chem. 273, 7044-7051.
16. Morris A. J., Hammond S. M., Colley C., Sung T.-C., Jenco J. M., Sciorra V. A., Rudge S. A., and Frohman M. A. (1997) Regulation and functions of phospholipase D. Biochem. Soc. Trans. 25, 1152-1157.
17. Pinhas-Hamiel O., Barak Y., Siev-Ner I., and Achiron A. (1998) Juvenile multiple sclerosis: clinical features and prognostic characteristics. J. Pediatr. 132, 735-737.
18. Poser C. M., Paty D. W., Scheinberg L., et al. (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 13, 227-231.
19. Sadovnick A. D., Yee I. M., Ebers G. C., and Rich N. J. (1988) Effect of age at onset and parental disease status on sibling risks for MS. Neurology 50, 719-723.
20. Sawcer S., Jones H. B., Feakes R., Gray J., Smaldon N., Chataway J., Robertson N., Clayton D., Goodfellow P. N., and Compston A. (1996) A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nature Genet. 13, 464-468.
21. Sindren E., Hass J., Stark E., and Wurster U. (1992) Early onset MS under the age of 16: clinical and paraclinical features. Acta Neurol Scand. 86, 280-284.