Hybrid peptides constructed from RES-701-1, an endothelin B receptor antagonist, and endothelin; binding selectivity for endothelin receptors and their pharmacological activity

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 12, 1998, Pages 2459-2467

  Shibata, Kenji ^a   Suzawa, Toshiyuki ^a   Ohno, Tetsuji ^a   Yamada, Koji ^a   Tanaka, Takeo ^a   Tsukuda, Eiji ^a   Matsuda, Yuzuru ^a   Yamasaki, Motoo ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Agonists; Antagonists; Peptides and polypeptides; Receptors

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR AGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; HYBRID PROTEIN; RECEPTOR SUBTYPE; RES 701 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DEPRESSOR RESPONSE; DOSE RESPONSE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; HUMAN; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PEPTIDE SYNTHESIS; PROTEIN STRUCTURE; RAT; VASOCONSTRICTION;

EID: 0032442833     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)80020-5     Document Type: Article

References (25)

1. Simonson, M. S.; Dunn, M. J. Hypertension 1991, 17, 856.
2. Rubanyi, G. M.; Parker Botelho, L. H. FASEB J. 1991, 5, 2713.
3. Yanagisawa, M.; Kurihara, H.; Kimura, S.; Tomobe, Y.; Kobayashi, M.; Mitsui, Y.; Yazaki, Y.; Goto, K.; Masaki, T. Nature 1988, 332, 411.
4. Miller, R. C.; Pelton, J. T.; Muggins, J. P. Trends Pharmacol. Sci. 1993, 14, 54.
5. Bax, W. A.; Saxena, P. R. ibid. 1994, 15, 379.
6. Haynes, W. G.; Davenport, A. P.; Webb, D. J. ibid. 1993, 14, 225.
7. Douglas, S. A. ibid. 1997, 18, 408.
8. Morishita, Y.; Chiba, S.; Tsukuda, E.; Tanaka, T; Ogawa, T.; Yamasaki, M.; Yoshida, M.; Kawamoto, I.; Matsuda, Y. J. Antibiot. 1994, 47, 269.
9. Yamasaki, M.; Yano, K.; Matsuda, Y.; Yamaguchi, K. ibid. 1994, 47, 276.
10. Karaki, H.; Matsuda, Y. Cardiovasc. Drug Rev. 1996, 14, 17.
11. Suzawa, T.; Shibata, K.; Tanaka, T.; Matsuda, Y.; Yamasaki, M. Bioorg. Med. Chem. Lett. 1997, 7, 1715.
12. Takai, M.; Umemura, I.; Yamasaki, K.; Watakabe, T.; Fujitani, Y.; Oda, K.; Urade, Y.; Inui, T.; Yamamura, T.; Okada, T. Biochem. Biophys. Res. Commun. 1992, 184, 953.
13. James, A. F.; Urade, Y.; Webb, R. L.; Karaki, H.; Umemura, I.; Fujitani, Y.; Oda, K.; Okada, T.; Lappe, R. W.; Takai, M. Cardiovasc. Drug Rev. 1993, 11, 253.
14. He, J. X.; Cody, W. L.; Flynn, M. A.; Welch, K. M.; Reynolds, E. E.; Doherty, A. M. Bioorg. Med. Chem. Lett. 1995, 5, 621.
15. Ihara, M.; Fukuroda, T.; Saeki, T.; Nishikibe, M.; Kokiri, K.; Suda, A.; Yano, M. Biochem. Biophys. Res. Commun. 1991, 178, 132.
16. Kikuchi, T.; Kubo, K.; Ohtaki, T.; Suzuki, N.; Asami, T.; Shimamoto, N.; Wakimasu, M.; Fujino, M. J. Med. Chem. 1993, 36, 4087.
17. Katahira, R.; Shibata, K.; Yamasaki, M.; Matsuda, Y.; Yoshida, M. Bioorg. Med. Chem. 1995, 3, 1273.
18. Kimura, S.; Kasuya, Y.; Sawamura, T.; Shinmi, O.; Sugita, Y.; Yanagisawa, M.; Goto, K.; Masaki, T. Biochem. Biophys. Res. Commun. 1988, 156, 1182.
19. Shibata, K.; Yano, K.; Tanaka, T.; Matsuda, Y.; Yamasaki, M. Bioorg. Med. Chem. Lett. 1996, 6, 775.
20. Urade, Y.; Fujitani, Y.; Oda, K.; Watakabe, T.; Umemura, I.; Takai, M.; Okada, T.; Sakata, K.; Karaki, H. FEBS Lett. 1992, 311, 12.
21. Tanaka, T.; Tsukuda, E.; Nozawa, M.; Nonaka, H.; Ohno, T.; Kase, H.; Yamada, K.; Matsuda, Y. Mol. Pharmacol. 1994, 45, 724.
22. Sudjarwo, S. A.; Hori, M.; Tanaka, T.; Matsuda, Y.; Okada, T.; Karaki, H. Biochem. Biophys. Res. Commun. 1994, 200, 627.
23. Natarajan, S.; Hunt, J. T.; Festin, S.; Serafino, R.; Zhang, R. A.; Moreland, S. Life Sci. 1995, 56, 1251.
24. Nomenclature and Symbolism for Amino Acids and Peptides. Eur. J. Biochem. 1984, 138, 9.
25. Fields, G. B; Noble, R. L. Int. J. Peptide Protein Res. 1990, 35, 161.