Synthesis and dihydrofolate reductase inhibitory activity of N4-2-L- glutaryl-N1-heteroaryl thiosemicarbazones

Medicinal Chemistry Research

Volumn 8, Issue 9, 1998, Pages 542-553

  Foye, William O ^a   Dabade, Sunil V ^a   Kelley, Charles J ^a   Lebrun, Evelyne ^b   Van Rapenbusch, Roland ^b  

^a MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b UNIVERSITÉ DE ROUEN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; GLUTARIC ACID DERIVATIVE; METHOTREXATE; N4 [(2 ACETOXYETHOXY)METHYL]N1 2 ACETYLPYRIDINE THIOSEMICARBAZONE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CATTLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG EFFECT; DRUG MECHANISM; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; GROWTH INHIBITION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TUMOR CELL LINE;

EID: 0032442339     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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