Bradycardia and hypotension associated with severe hemorrhage are reversed by morphine given centrally or peripherally in anesthetized rats

Journal of Trauma - Injury, Infection and Critical Care

Volumn 45, Issue 6, 1998, Pages 1024-1030

  Ohnishi, Mitsuo ^b   Kirkman, Emrys ^a   Hiraide, Atsushi ^b   Little, Roderick A ^b  

^a DURHAM UNIVERSITY   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BRADYCARDIA; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; HYPOTENSION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; REFLEX;

EID: 0032441171     PISSN: 00225282     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005373-199812000-00009     Document Type: Article

References (33)

1. Barcroft H, Edholm OG, McMichael J, Sharpy-Schafer EP. Posthaemorrhagic fainting: Study by cardiac output and forearm flow. Lancet 1:489,1944.
2. Little RA, Marshall HW, Kirkman E. Attenuation of the acute cardiovascular-responses to haemorrhage by tissue-injury in the conscious rat. Q J Exp Physiol. 1989;74:825.
3. Secher NH, Bie P. Bradycardia during reversible hemorrhagic shock: a forgotten observation. Clin Physiol. 1985;5:315.
4. Sander-Jensen K, Secher NH, Bie P, Warberg J, Schwartz TW. Vagal slowing of the heart during haemorrhage: observations from 20 consecutive hypotensive patients. Br Med J. 1986;292:364.
5. Secher NH, Jacobsen J, Friedman DB, Matzen S. bradycardia during reversible hypovolemic shock -associated neural reflex mechanisms and clinical implications. Clin Exp Pharmacol Physiol. 1992;19:733.
6. Little RA, Randall PE, Redfern WS, Stoner HB, Marshall HW. Components of injury (haemorrhage and tissue ischaemia) affecting cardiovascular reflexes in man and rat. Q J Exp Physiol. 1984;69:753.
7. Hoffman RL. Rupture of the spleen. A review and report of a case following abdominal hysterectomy. Am J Obstet Gynecol. 1972;113:524.
8. Oberg B, Thoren P. Increased activity in left ventricular receptors during haemorrhage on occlusion of the caval veins in the cat: a possible cause of the vasovagal reaction. Acta Physiol Scand. 1972;85:164.
9. Scherrer U, Vissing S, Morgan BJ, Hanson P, Victor RG. Vasovagal syncope after infusion of a vasodilator in a heart-transplant recipient. N Engl J Med. 1990;322:603.
10. Kirkman E, Shiozaki T, Little RA. Methiothepin does not attenuate the bradycardia associated with severe haemorrhage in the anaesthetised rat. Br J Pharmacol. 1994; 112:111P.
11. Ohnishi M, Kirkman E, Marshall HW, Little RA. Morphine blocks the bradycardia associated with severe hemorrhage in the anesthetized rat. Brain Res. 1997;763:39.
12. Evans RG, Ludbrook J. Effects of mu-opioid receptor agonists on circulatory responses to simulated haemorrhage in conscious rabbits. Br J Pharmacol. 1990;100:421.
13. Evans RG, Ludbrook J. Chemosensitive cardiopulmonary afferents and the haemodynamic-response to simulated haemorrhage in conscious rabbits. Br J Pharmacol. 1991; 102:533.
14. Evans RG, Ludbrook J, Vanleeuwen AF. Role of central opiate receptor subtypes in the circulatory responses of awake rabbits to graded caval occlusions. J Physiol. 1989; 419:15.
15. Anthony PP, Clarke T, Sarsfield P. Pain, blood loss and death from leaking abdominal aortic aneurysms. J Clin Pathol. 1994;47:272.
16. Hoppe DE, Bekkar BE, Nager CW. Single-dose systemic methotrexate for the treatment of persistent ectopic pregnancy after conservative surgery. Obstet Gynecol. 1994; 83:51.
17. Elebute EA, Little RA. Effect of streptozotocin-diabetes on the local and general responses to injury in the rat. Clin Sci. 1978;54:431.
18. Ludblook J. Repeated measurements and multiple comparisons in cardiovascular research. Cardiovasc Res. 1994;28:303.
19. Ohnishi M, Kirkman E, Marshall HW, Little RA. Morphine reverses the bradycardia and hypotension associated with severe haemorrhage. J Accid Emerg Med. 1997;14:123.
20. Acker H, O'Regan RG. The effects of stimulation of autonomic nerves on carotid body blood flow in the cat. J Physiol. 1981;315:99.
21. Daly MB, Lambertsen CJ, Schweitzer A. Observations on the volume of blood flow and oxygen utilization of the carotid body of the cat. J Physiol. 1954;125:67.
22. Potter EK, McCloskey DI. Excitation of carotid-body chemoreceptors by neuropeptide-Y. Respir Physiol. 1987; 67:357.
23. Daly MB, Kirkman E. Cardiovascular-responses to stimulation of pulmonary C fibers in the cat: their modulation by changes in respiration. J Physiol. 1988; 402:43.
24. Daly MB, Kirkman E. Differential modulation by pulmonary stretch afferents of some reflex cardioinhibitory responses in the cat. J Physiol. 1989;417:323.
25. Daly MB, Kirkman E, Wood LM. Cardiovascular-responses to stimulation of cardiac receptors in the cat and their modification by changes in respiration. J Physiol. 1988; 407:349.
26. Blake DW, Evans RG, Ludbrook J, Petring OU. Interactions between the circulatory effects of central hypovolemia and arterial hypoxia in conscious rabbits. Clin Exp Pharmacol Physiol. 1994;21:383.
27. Mansour A, Fox CA, Thompson RC, Akil H, Watson SJ. Mu-opioid receptor messenger-RNA expression in the rat CNS: comparison to mu-receptor binding. Brain Res. 1994; 643:245.
28. McAllen RM, Badoer E, Shafton AD, Oldfield BJ, McKinley, MJ. Hemorrhage induces c-fos immunoreactivity in spinally projecting neurons of cat subretrofacial nucleus. Brain Res. 1992;575:329.
29. Marshall HW, Prehar S, Kirkman E, Little RA, Ohnishi M. Morphine increases mortality after haemorrhage in the rat. J Accid Emerg Med. 1998;15:133.
30. Stern SA, Dronen SC, Birrer P, Wang X. Effect of blood -pressure on hemorrhage volume and survival in a near-fatal hemorrhage model incorporating a vascular injury. Ann Emerg Med. 1993;22:155.
31. Bickell WH, Wall MJ, Pepe PE, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med. 1994;331:1105.
32. Prys-Roberts C. Anaesthesia for major vascular surgery. In: Prys-Roberts C, Brown BR Jr, eds. International Practice of Anaesthesia. Oxford, UK: Butterworth-Heinemann; 1996: 1/49/1-1/49/21.
33. Holder KJ. Preterm labour, instrumental delivery, malpresentation, multiple births and ectopic pregnancy. In: Prys-Roberts C, Brown BR Jr, eds. International Practice of Anaesthesia. Oxford, UK: Butterworth-Heinemann; 1996: 2/97/1-2/97/11.