Novel system for real-time ex vivo lactate monitoring in human whole blood

Biosensors and Bioelectronics

Volumn 13, Issue 12, 1998, Pages 1271-1278

  Gfrerer, R J ^a,d   Brunner, G A ^a   Trajanoski, Z ^a   Schaupp, L ^a   Sendlhofer, G ^a   Skrabal, F ^b   Jobst, G ^c   Moser, I ^c   Urban, G ^c   Pieber, T R ^a   Wach, P ^a,d  

^a UNIVERSITY OF GRAZ   (Austria)

^b KRANKENHAUS DER BARMHERZIGEN BRÜDER   (Austria)

^c UNIVERSITY OF FREIBURG   (Germany)

^d LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

Biosensor array; Blood lactate monitoring; Heparin coating

Indexed keywords

AMINO ACIDS; AMPEROMETRIC SENSORS; BLOOD; CATHETER TIP SENSORS; MICROSENSORS; PLASTIC COATINGS; POLYSACCHARIDES;

HEPARIN; LACTATE;

ENZYME SENSORS;

HEPARIN; LACTIC ACID;

ADULT; AMPEROMETRY; ARTICLE; BIOSENSOR; BLOOD SAMPLING; CATHETER; COMPUTER ASSISTED DIAGNOSIS; COMPUTER SYSTEM; ENZYME ASSAY; HUMAN; HUMAN EXPERIMENT; LACTATE BLOOD LEVEL; MALE; NORMAL HUMAN; SERODIAGNOSIS;

ADULT; BIOSENSING TECHNIQUES; HEPARIN; HUMANS; LACTIC ACID; MALE;

EID: 0032436507     PISSN: 09565663     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0956-5663(98)00090-6     Document Type: Article

References (17)

1. Bland, J.M., Altman, D.G., 1989. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet, i, 307-310.
2. Brückel J., Zier H., Kerner W., Pfeiffer E.F. Progress in practical endocrinology. The glucose sensor Unitec Ulm - a portable monitor for continuous blood glucose measurement. Horm. Metab. Res. 22:1990;382-384.
3. Hakanson H., Kyröläinen M., Mattiasson B. Portable System for continuous ex vivo measurements of lactate. Biosensors and Bioelectronics. 8:1993;213-217.
4. Hoffmann J., Larm O., Scholander E. A new method for covalent coupling of heparin and other glycosaminoglycans to substances containing primary amino groups. Carbohydrate Research. 117:1983;328-331.
5. Jobst G., Moser I., Svasek P., Varahram M., Trajanoski Z., Wach P., Kotanko P., Skrabal F., Urban G. Mass producible miniaturized flow through device with biosensor array. Sensors and Actuators. B43:1997;121-125.
6. Jobst G., Moser I., Varahram M., Svasek P., Aschauer E., Trajanoski Z., Wach P., Kotanko P., Skrabal F., Urban G. Thin-film microbiosensors for glucose-lactate monitoring. Anal. Chem. 68:1996;3173-3179.
7. Larm O., Larsson R., Olsson P. A new non-thrombogenic surface prepared by selective covalent binding of heparin via a modified reducing terminal residue. Biomat. Med. dev. Art. Org. 11(2)(3):1983;161-173.
8. Larm, O., Larsson, R. and Olsson, P., 1989. Surface immobilized heparin, chemical and biological properties, Clinical Applications, 597-608.
9. Li-Chien H. Biocompatibility in heparin-coated extracorporeal circuits. Perfusion. 11:1996;256-263.
10. Lindhout T., Blezer R., Schoen P., Willems G.M., Fouache B., Verhoeven M., Hendriks M., Calahan L., Calahan P.T. Antithrombin activity of surface-bound heparin studied under flow conditions. Journal of Biomedical Materials Research. 29:1995;1255-1266.
11. Matheve C. Clinical evidence of improved biocompatibility using heparin-coated surfaces. Perfusion. 11:1996;264-269.
12. Sheppard A.M., Lesho M.J., McNally P., Francomacaro A.S. Microfabricated conductimetric pH sensor. Sensors and Actuators B. 28:1995;95-102.
13. Trajanoski Z., Wach P., Gfrerer R., Jobst G., Urban G., Kotanko P., Skrabal F. Portable device for continuous fractionated blood sampling and continuous ex vivo blood glucose monitoring. Biosensors and Bioelectronics. 11:1996;479-487.
14. Urban G., Jobst G., Keplinger F., Aschauer E., Fasching R., Svasek P. Miniaturized integrated biosensors, Technol. Hlth Care. 1:1994;215-218.
15. Urban G., Jobst G., Keplinger F., Aschauer E., Tilado O., Fasching R., Kohl F. Miniaturized multi-enzyme biosensors integrated with pH-sensors of flexible polymer carriers for in vivo applications. Biosensors and Bioelectronics. 7:1992;733-739.
16. Yang Q., Atanasov P., Wilkins E. A needle-type sensor for monitoring glucose in whole blood. Biomed Instrum Technol. 31(1):1997;54-62.
17. Yii M., Gourlay T., Fleming J. Evaluation of Carmeda® Bioactive Surface (CBAS®), Duraflo II and a novel nonspecific protease-modified surface using a new in vitro model simulating cardiopulmonary bypass. Perfusion. 11:1996;229-240.