Staphylococcus aureus serotype 5 capsular polysaccharide is antiphagocytic and enhances bacterial virulence in a murine bacteremia model

Infection and Immunity

Volumn 66, Issue 11, 1998, Pages 5183-5189

  Thakker, Manoj ^a   Park, Jin Sir ^a   Carey, Vincent ^a   Lee, Jean C ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CHANNING LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL POLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTEREMIA; BACTERIAL GROWTH; BACTERIAL VIRULENCE; CONTROLLED STUDY; FEMALE; MOUSE; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION;

EID: 0032435634     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.11.5183-5189.1998     Document Type: Article

References (5)

1. Adlam, C., J. C. Anderson, J. P. Arbuthnott, C. S. F. Easmon, and W. C. Noble. 1983. Animal and human models of staphylococcal infection, p. 357-384. In C. S. F. Easmon and C. Adlam (ed.), Staphylococci and staphylococcal infections, vol. 1. Academic Press, New York, N.Y.
2. Albus, A., R. D. Arbeit, and J. C. Lee. 1991. Virulence of Staphylococcus aureus mutants altered in type 5 capsule production. Infect. Immun. 59:1008-1014.
3. Albus, A., J. M. Fournier, C. Wolz, A. Boutonnier, M. Ranke, N. Hoiby, H. Hochkeppel, and G. Doring. 1988. Staphylococcus aureus capsular types and antibody response to lung infection in patients with cystic fibrosis. J. Clin. Microbiol. 26:2505-2509.
4. Arbeit, R. D., W. W. Karakawa, W. F. Vann, and J. B. Robbins. 1984. Predominance of two newly described capsular polysaccharide types among clinical isolates of Staphylococcus aureus. Diagn. Microbiol. Infect. Dis. 2:85-91.
5. Baddour, L. M., C. Lowrance, A. Albus, J. H. Lowrance, S. K. Anderson, and J. C. Lee. 1992. Staphylococcus aureus microcapsule expression attenuates bacterial virulence in a rat model of experimental endocarditis. J. Infect. Dis. 165:749-753.