Cephalosporin C production by Cephalosporium acremonium: The methionine story

Critical Reviews in Biotechnology

Volumn 18, Issue 4, 1998, Pages 283-294

  Demain, Arnold L ^a   Zhang, Jinyou ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Acremonium chrysogenum; Cephalosporin C; Cephalosporium acremonium; Enzyme induction; Fermentation; Methionine

Indexed keywords

CEPHALOSPORIN C; CYSTATHIONINE GAMMA LYASE; DEACETOXYCEPHALOSPORIN C; ISOPENICILLIN N SYNTHETASE; METHIONINE; NORLEUCINE; SULFUR; SYNTHETASE;

ANTIBIOTIC BIOSYNTHESIS; AUXOTROPHY; BACTERIUM MUTANT; CELL STRUCTURE; CEPHALOSPORIUM ACREMONIUM; ENZYME INDUCTION; FERMENTATION; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ACREMONIUM; CEPHALOSPORINS; CYSTATHIONINE; CYSTEINE; DRUG RESISTANCE, MICROBIAL; ENZYME INDUCTION; FERMENTATION; LIGASES; METHIONINE; SELENOMETHIONINE; SULFUR;

ACREMONIUM CEPHALOSPORIUM; ACREMONIUM CHRYSOGENUM; BACTERIA (MICROORGANISMS); CEPHALOSPORIUM;

EID: 0032435476     PISSN: 07388551     EISSN: None     Source Type: Journal    
DOI: 10.1080/0738-859891224176     Document Type: Review

References (49)

1. Alonso, M. J. and Luengo, J. M. 1987. Interference by methionine on valine uptake in Acremonium chrysogenum. Antimicrob. Agents Chemother. 31: 357-359.
2. Banko, G., Wolfe, S. and Demain, A. L. 1986. Cell-free synthesis of δ-(L-α-aminoadipyl)-L-cysteine, the first intermediate of penicillin and cephalosporin biosynthesis. Biochem. Biophys. Res. Commun. 137: 528-535.
3. Banko, G., Demain, A. L. and Wolfe, S. 1987. δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase: a multi-functional enzyme with broad substrate specificity for synthesis of penicillin and cephalosporin precursors. J. Am. Chem. Soc. 109: 2858-2860.
4. Bartoshevich, Y. E., Zaslavskaya, P. L., Novak, M. J., and Yudina, O. D. 1990. Acremonium chrysogenum differentiation and biosynthesis of cephalosporin,. J. Basic Microbiol. 30: 313-320.
5. Caltrider, P. G. and Niss, H. F. 1966. Role of methionine in cephalosporin synthesis. Appl. Microbiol. 14: 746-753.
6. Caltrider, P.G., Huber, F. M., and Day, L. E. 1968. Effect of methionine on the metabolism of Cephalosporium acremonium. Appl. Microbiol. 16: 1913-1918.
7. Dennen, D. W. and Carver, D. D. 1969. Sulfatase regulation and antibiotic synthesis in Cephalosporium acremonium. Can. J. Microbiol. 15: 175-181.
8. Demain, A. L. and Newkirk, J. F. 1962. Biosynthesis of cephalosporin C. Appl. Microbiol. 10: 321-325.
9. Demain, A. L. 1963. Synthesis of cephalosporin C by resting cells of Cephalosporium sp. Clin. Med. 70: 2045-2051.
10. Demain, A. L. Newkirk, J. F., and Hendlin, D. 1963. Effect of methionine, norleucine, and lysine derivatives on cephalosporin C formation in chemically defined media. J. Bacteriol. 85: 339-344.
11. Drew, S. W. and Demain, A. L. 1973. Methionine control of cephalosporin C formation. Biotechnol. Bioeng. 15: 743-754.
12. Drew, S. W. and Demain, A. L. 1975a. The obligatory role of methionine in the conversion of sulfate to cephalosporin C. Eur. J. Appl. Microbiol. 2: 121-128.
13. Drew, S. W. and Demain, A. L. 1975b. Production of cephalosporin C by single and double sulfur auxotrophic mutants of Cephalosporium acremonium. Antimicrob. Agents Chemother. 8: 5-10.
14. Drew, S. W. and Demain, A. L. 1975c. Stimulation of cephalosporin production by methionine peptides in a mutant blocked in reverse transsulfuration. J. Antibiot. 28: 889-895.
15. Drew, S. W., Winstanley, D. J., and Demain, A. L. 1976. Effect of norleucine on mycelial fragmentation in Cephalosporium acremonium. Appl. Environ. Microbiol. 31: 143-145.
16. Gygax, D., Döbeli, H., and Nüesch, J. 1980. Correlation between β-lactam antibiotics production and γ-cystathionase activity. Abstract. Experientia 36: 487.
17. Kavanagh, F., Tunin, D., and Wild, G. 1958. D-Methionine and the biosynthesis of cephalosporin N. Arch. Biochem. Biophys. 77: 268-274.
18. Komatsu, K.-I., Mizuno, M., and Kodaira, R. 1975. Effect of methionine on cephalosporin C and penicillin N production by a mutant of Cephalosporium acremonium. J. Antibiot. 28: 881-888.
19. Lee, K., Choi, S. H., Lee, J. J., and Mheen, T. I. 1987a. Characterization of methionine analogue-resistant mutant of Cephalosporium acremonium. Kor. J. Microbiol. 25: 205-211.
20. Lee, K., Choi, S. H., Lee, J. J., and Mheen, T. I. 1987b. Regulation of sulfur metabolism in Cephalosporium acremonium. Kor. J. Appl. Microbiol. Bioeng. 15: 361-367.
21. Liersch, M., Treichler, H. J., and Nüesch, J. 1980. Correlation between cysteine synthase activity and cephalosporin production in Cephalosporium acremonium. Abstract. Experientia 36: 487.
22. Malmberg, L. H. and Hu, W.-S. 1990. Kinetic analysis of cephalosporin C biosynthesis. (Abstr.) 200th Amer. Chem. Soc. Mtg., Div. Biochem. Technol., American Chemical Society, Washington, DC.
23. Malmberg, L. H. and Hu, W.-S. 1992. Identification of rate-limiting steps in cephalosporin C biosynthesis in Cephalosporium acremonium: a theoretical analysis. Appl. Microbiol. Biotechnol. 38: 122-128.
24. Malmberg, L. H., Sherman, D. H. and Hu, W.-S. 1992. Analysis of rate-limiting reactions in cephalosporin biosynthesis. Ann. N.Y. Acad. Sci. 665: 16-26.
25. Martin, J. F. and Demain, A. L. 1980. Control of antibiotic biosynthesis. Microbiol. Rev. 44: 230-251.
26. Matsumura, M., Imanaka, T., Yoshida, T., and Taguchi, H. 1978. Effect of glucose and methionine consumption on cephalosporin C production by Cephalosporium acremonium. J. Ferm. Technol. 56: 345-353.
27. Matsumura, M., Imanaka, T., Yoshida, T., and Taguchi, H. 1980a. Morphological differentiation in relation to cephalosporin C synthesis by Cephalosporium acremonium. J. Ferm. Technol. 58: 197-204.
28. Matsumura, M., Imanaka, T., Yoshida, T., and Taguchi, H. 1980b. Regulation of cephalosporin C production by endogenous methionine in Cephalosporium acremonium. J. Ferm. Technol. 58: 205-214.
29. Matsumura, M., Imanaka, T., Yoshida, T., and Taguchi, H. 1981. Modeling of cephalosporin C production and its application to fed-batch culture. J. Ferm. Technol. 59: 115-123.
30. Matsumura, M., Yoshida, T., and Taguchi, H. 1982. Synthesis of cephalosporin C by a methionine analogue resistant mutant of Cephalosporium acremonium. Eur. J. Appl. Microbiol. Biotechnol. 16: 114-118.
31. Miller, G. A., Kelly, B. K., and Newton, G. G. F. 1956. Cephalosporin Production. British Patent 759,624. Issued Oct. 24, 1956.
32. Nash, C. H. and Huber, F. M. 1971. Antibiotic synthesis and morphological differentiation of Cephalosporium acremonium. Appl. Microbiol. 22: 6-10.
33. Natorff, R., Balinska, M., and Paszewski, A. 1993. At least four regulatory genes control sulfur metabolite repression in Aspergillus nidulans. Mol. Gen. Genet. 238: 185-192.
34. Nüesch, J., Treichler, H. J., and Liersch, M. 1973. The biosynthesis of cephalosporin C. In: Genetics of Industrial Microorganisms: Actinomycetes and Fungi. pp. 309-334. Vanek, Z., Hostálek, Z., and Cudlín, J., Eds., American Elsevier, New York.
35. Nüesch, J., Heim, J., and Treichler, H.-J. 1987. The biosynthesis of sulfur-containing β-lactam antibiotics. Ann. Rev. Microbiol. 41: 51-75.
36. Ott, J. L., Godzeski, C. W., Pavey, D., Farran, J. D., and Horton, D. R. 1962. Biosynthesis of cephalosporin C. 1. Factors affecting the fermentation. Appl. Microbiol. 10: 515-523.
37. Queener, S. W., Wilkerson, S., Tunin, D. R., McDermott, J. P., Chapman, J. L., Nash, C., Platt, C., and Westpheling, J. 1984. Cephalosporin C fermentation: biochemical and regulatory aspects of sulfur metabolism, In: Biotechnology of Industrial Antibiotics. pp. 141-170. Vandamme, E. J., ed.. Marcel Dekker, New York,
38. Ramos, F. R., López-Nieto, M. J., and Martin, J. F. 1986. Coordinate increase of penicillin N synthetase, isopenicillin N epimerase and deacetoxycephalosporin C synthetase in a high cephalosporin-producing mutant of Acremonium chrysogenum and simultaneous loss of the three enzymes in a non-producing mutant. FEMS Microbiol. Lett. 35: 123-127.
39. Sawada, Y., Konomi, T., Solomon, N. A., and Demain, A. L. 1980. Increase in activity of β-lactam synthetases after growth of Cephalosporium acremonium with methionine or norleucine. FEMS Microbiol. Lett. 9: 281-284.
40. Shen, Y.-Q., Wolfe, S., and Demain, A. L. 1986. Levels of isopenicillin N synthetase and deacetoxycephalosporin C synthetase in Cephalosporium acremonium producing high and low levels of cephalosporin C. Bio/Technology 4: 61-63.
41. Shirafuji, H., Fujisawa, Y., Kida, M., Kanzaki, T., and Yoneda, M. 1979. Accumulation of tripeptide derivatives by mutants of Cephalosporium acremonium. Agric. Biol. Chem. 43: 155-160.
42. Smith, B., Warren, S. C., Newton, G. G. F., and Abraham, E. P. 1967. Biosynthesis of penicillin N and cephalosporin C. Antibiotic production and other features of the metabolism of a Cephalosporium sp. Biochem J. 103: 877-890.
43. Treichler, H. J., Liersch, M., and Nüesch, J. 1978. Genetics and biochemistry of cephalosporin biosynthesis. In: Antibiotics and Other Secondary Metabolites. pp. 177-199. Hütter, R., Leisinger, T., Nüesch, J., and Wehrli, W., Eds., Academic Press, London.
44. Treichler, H. J., Liersch, M., Nüesch, J., and Döbeli, H. 1979. Role of sulfur metabolism in cephalosporin C and penicillin biosynthesis. In: Genetics of Industrial Microorganisms. pp. 97-104. Sebek, O.K., and Laskin, A.L., Eds., American Society for Microbiology, Washington DC.
45. Velasco, J., Gutierrez, S., Fernandez, F. J., Marcos, A. T., Arenos, C., and Martin, J. F. 1994. Exogenous methionine increases levels of mRNAs transcribed from pcbAB, pcbC, and cefEF genes, encoding enzymes of the cephalosporin biosynthetic pathway, in Acremonium chrysogenum. J. Bacteriol. 176: 985-991.
46. Yoshida, M., Konomi, T., Kohsaka, M., Baldwin, J. E., Herchen, S., Singh, P., Hunt, N. A., and Demain, A. L. 1978. Cell-free ring expansion of penicillin N to deacetoxycephalosporin C by Cephalosporium acremonium CW-19 and its mutants. Proc. Natl. Acad. Sci. U.S.A. 75: 6253-6257.
47. Zhang, J. and Demain, A. L. 1991. ACV synthetase. Crit. Rev. Biotechnol. 12: 245-260.
48. Zhang, J. and Demain, A. L. 1992. Regulation of ACV synthetase in penicillin- and cephalosporin-producing microorganisms. Biotechnol. Adv. 9: 623-641.
49. Zhang, J., Banko, G., Wolfe, S., and Demain, A. L. 1987. Methionine induction of ACV synthetase in Cephalosporium acremonium. J. Indust. Microbiol. 2: 251-255.