DNA minor groove targeted alkylating agents based on bisbenzimidazole carriers: Synthesis, cytotoxicity and sequence-specificity of DNA alkylation

Anti-Cancer Drug Design

Volumn 13, Issue 8, 1998, Pages 857-880

  Smaill, Jeff B ^a   Fan, Jun Yao ^a   Denny, William A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Aniline mustard; Bis(hydroxymethyl) pyrrole; Bisbenzimidazole; Cytotoxicity; Sequence specific DNA alkylation

Indexed keywords

ADENINE; ALKYLATING AGENT; ANILINE MUSTARD; CHLORAMBUCIL; DRUG CARRIER; GUANINE; IMIDAZOLE; OLIGONUCLEOTIDE; PIBENZIMOL;

ARTICLE; CHEMICAL STRUCTURE; CYTOTOXICITY; DNA ALKYLATION; DNA CLEAVAGE; DNA CROSS LINKING; DNA SEQUENCE; DNA STRAND; DRUG SYNTHESIS; GEOMETRY; ORIENTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BASE SEQUENCE; BENZIMIDAZOLES; CATTLE; DNA ADDUCTS; DRUG SCREENING ASSAYS, ANTITUMOR; LEUKEMIA P388; MUSTARD COMPOUNDS;

EID: 0032434967     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

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