Tau protein in cerebrospinal fluid: A new diagnostic and prognostic marker in Alzheimer disease?

Alzheimer Disease and Associated Disorders

Volumn 12, Issue 3, 1998, Pages 211-214

  Mecocci, Patrizia ^a   Cherubini, Antonio ^b   Bregnocchi, Mario ^c   Chionne, Fausto ^a   Cecchetti, Roberta ^a   Lowenthal, David T ^b   Senin, Umberto ^c  

^a UNIVERSITY OF PERUGIA   (Italy)

^b Department of Medical Physics Policlinico Montelnce   (Italy)

^c UNIVERSITY OF FLORIDA HEALTH JACKSONVILLE   (United States)

Author keywords

Alzheimer disease; Cerebrospinal fluid; Diagnostic marker; Senile dementia; Tau protein

Indexed keywords

TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FRONTAL LOBE; HUMAN; MALE; MULTIINFARCT DEMENTIA; ONSET AGE; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL;

EID: 0032433590     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002093-199809000-00015     Document Type: Article

References (23)

1. American Psychiatrie Association. Diagnostic and statistical manual of mental disorders, 3rd ed, rev. Washington, DC: American Psychiatrie Association, 1987.
2. Arai H, Terajima M, Miura M, et al. Tau in cerebrospinal fluid: a potential diagnostic marker in Alzheimer's disease. Ann Neural 1995;38:649-52.
3. Berg L, Morris JC. Diagnosis. In: Terry RD, Katzman R, Bick KL, eds. Alzheimer disease. New York: Raven Press, 1994:9-25.
4. Blennow K, Wallin A, Agren H, Spenger C, Siegfried J, Vanmechelen E. Tau protein in cerebrospinal fluid. A biochemical marker for axonal degeneration in Alzheimer disease? Mol Chem Neitwpathol 1995;26:231-41.
5. Blennow K, Wallin A, Gottfries CG. Confusional symptomatology distinguishes early- and late-onset Alzheimer's disease. Aging 1990;2:395-401.
6. Bouras C, Hof PR, Giannakopoulos P, Michel JP, Morrison JH. Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation in the hippocampus and the temporal neocortex: a study of one year autopsy population from a geriatric hospital. Cereb Cortex 1994;4:138-50.
7. Brun A. Frontal lobe degeneration of non-Alzheimer type revisited. Dementia 1993;4:126-31.
8. Giannakopoulos P, Hof PR, Surini M, Michel JP, Bouras C. Quantitative immunoistochemical analysis of the distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of nonagenarians and centenarians. Ada Neuropatliol 1993;85:602-10.
9. Goedert M, Spillantini MG, Cairns NJ, Cowther, RA. Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron 1992;8:159-68.
10. Gustafson L. Frontal lobe degeneration of non-Alzheimer type. 2. Clinical picture and differential diagnosis. Arch Gerontol Geriatr 1987;6:209-23.
11. Hock C, Golombowski S, Naser W, Müller-Spahn F. Increased levels of T protein in cerebrospinal fluid of patients with Alzheimer's disease. Correlation with degree of cognitive impairment. Ann NeumI I995;37:414-5.
12. Jensen M, Basun H, Lannfelt L. Increased cerebrospinal fluid tau in patients with Alzheimer's disease. Neurosci Lett 1995; 186:189-91.
13. Johnson GVW, Seubert P, Cox TM, Motter R, Brown JP, Galasko D. The T protein in human cerebrospinal fluid in Alzheimer's disease consists of proteolytically derived fragments. JNettrochem 1997;68:430-3.
14. Jorm AF, Körten AE, Henderson AS. The prevalence of dementia: a quantitative integration of the literature. Acta Pych Scand 1987;76:465-79.
15. Lund and Manchester Groups. Clinical and neuropathological criteria for frontotemporal dementia. J NeumI Neuwsurg Psychiatry 1994;57:416-8.
16. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984;34:939-44.
17. Mena R, Edwards PC, Harrington CR, Mukaetova-Ladinska EB, Wischik CM. Staging the pathological assembly of truncated tau protein into paired helical filaments in Alzheimer's disease. Acta Neuropathol 1996;91:633tl.
18. Mori H, Hosoda K, Matsubara E, et al. Tau in cerebrospinal fluid: establishment of the sandwich ELISA with antibody specific to repeat sequence in tau. Neurosci Lett 1995;186:181-3.
19. Roman GC, Tatemichi TK, Erkinjutti T, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neumlogy 1993;43:250-60.
20. Skoog I, Vanmechelen E, Andreasson LA, et al. A population-based study of tau protein and ubiquitin in cerebrospinal fluid in 85-year-olds: relation to severity of dementia and cerebral atrophy, but not to the apolipoprotein E4 allele. Neurodegeneration 1995;4:43342.
21. Tato RE, Frank A, Hernanz A. Tau protein concentrations in cerebrospinal fluid of patients with dementia of Alzheimer type. J NeumI Neuwsurg Psychiatry 1995;59:280-3.
22. Vandermeeren M, Mercken M, Vanmechelen E, et al. Detection of tau protein in normal and Alzheimer's disease cerebrospinal fluid with a sensitive sandwich enzyme-linked immunosorbent assay. JNeurochem 1993;61:1828-34.
23. Vigo-Pelfrey C, Seubert P, Barbour R, et al. Elevation of microtubuleassociated protein tau in the cerebrospinal fluid of patients with Alzheimer's disease. Neurology 1995;45:788-93.