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Volumn 6, Issue 4, 1998, Pages 239-247

2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin (TCDD); Apoptosis; C src; p53; Rat hepatocytes; Tumour promotion

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; PHOSPHOTRANSFERASE; PROTEIN P53;

EID: 0032433399     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1382-6689(98)00040-4     Document Type: Article
Times cited : (18)

References (54)
  • 1
    • 0028883726 scopus 로고
    • The liver-specific response to phenobarbital involves a transient increase in phosphorylation of a 34-kd nuclear protein in rat liver and in hepatocytes in culture
    • Baffet, G., Corcos, L., 1995. The liver-specific response to phenobarbital involves a transient increase in phosphorylation of a 34-kd nuclear protein in rat liver and in hepatocytes in culture. Biochem. Biophys. Res. Commun. 216, 947.
    • (1995) Biochem. Biophys. Res. Commun. , vol.216 , pp. 947
    • Baffet, G.1    Corcos, L.2
  • 2
    • 0031567124 scopus 로고    scopus 로고
    • The ability to alter the gap junction protein expression outside GST-P positive foci in liver of rats was associated to the tumour promotion potency of different polychlorinated biphenyls
    • Bager, Y., Kato, Y., Kenne, K., Warngard, L., 1997. The ability to alter the gap junction protein expression outside GST-P positive foci in liver of rats was associated to the tumour promotion potency of different polychlorinated biphenyls. Chem. Biol. Interact. 103, 199.
    • (1997) Chem. Biol. Interact. , vol.103 , pp. 199
    • Bager, Y.1    Kato, Y.2    Kenne, K.3    Warngard, L.4
  • 3
    • 0026534111 scopus 로고
    • Specific protein dephosphorylation in apoptosis induced by ionizing radiation and heat shock in human lymphoid tumor lines
    • Baxter, G.D., Lavin, M.F., 1992. Specific protein dephosphorylation in apoptosis induced by ionizing radiation and heat shock in human lymphoid tumor lines. J. Immunol. 148, 1949.
    • (1992) J. Immunol. , vol.148 , pp. 1949
    • Baxter, G.D.1    Lavin, M.F.2
  • 4
    • 0028208243 scopus 로고
    • Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin
    • Bayly, A., Roberts, R., Dive, C., 1994. Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin. J. Cell Biol. 125, 197.
    • (1994) J. Cell Biol. , vol.125 , pp. 197
    • Bayly, A.1    Roberts, R.2    Dive, C.3
  • 5
    • 0016333916 scopus 로고
    • Ethoxyresorufin direct fluorimetric assay of a microsomal O-dealkylation which is prererentially inducible by 3-methylcholanthrene
    • Burke, D., Mayer, R., 1974. Ethoxyresorufin direct fluorimetric assay of a microsomal O-dealkylation which is prererentially inducible by 3-methylcholanthrene. Drug Metab. Dispos. 2, 583.
    • (1974) Drug Metab. Dispos. , vol.2 , pp. 583
    • Burke, D.1    Mayer, R.2
  • 6
    • 0021248961 scopus 로고
    • Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters
    • Bursch, W., Lauer, B., Timmermann-Trosiener, I., Barthel, G., Schuppler, J., Schulte-Hermann, R., 1984. Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 5, 43.
    • (1984) Carcinogenesis , vol.5 , pp. 43
    • Bursch, W.1    Lauer, B.2    Timmermann-Trosiener, I.3    Barthel, G.4    Schuppler, J.5    Schulte-Hermann, R.6
  • 7
    • 0028837970 scopus 로고
    • Evidence for a second pathway in the action mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    • Enan, E., Matsumura, F., 1995. Evidence for a second pathway in the action mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Biochem. Pharmacol. 49, 249.
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 249
    • Enan, E.1    Matsumura, F.2
  • 8
    • 0030598390 scopus 로고    scopus 로고
    • Identification of c-src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway
    • Enan, E., Matsumura, F., 1996. Identification of c-src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway. Biochem. Pharmacol. 52, 1599.
    • (1996) Biochem. Pharmacol. , vol.52 , pp. 1599
    • Enan, E.1    Matsumura, F.2
  • 9
    • 0027174142 scopus 로고
    • Gene expression and cell proliferation in rat liver after 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure
    • Fox, T.R., Best, L.L., Goldsworthy, S.M., Mills, J.J., Goldsworthy, T.L., 1993. Gene expression and cell proliferation in rat liver after 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Cancer Res. 53, 2265.
    • (1993) Cancer Res. , vol.53 , pp. 2265
    • Fox, T.R.1    Best, L.L.2    Goldsworthy, S.M.3    Mills, J.J.4    Goldsworthy, T.L.5
  • 10
    • 0027500246 scopus 로고
    • Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents
    • Fritsche, M., Haessler, C., Brandner, G., 1993. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene 8, 307.
    • (1993) Oncogene , vol.8 , pp. 307
    • Fritsche, M.1    Haessler, C.2    Brandner, G.3
  • 12
    • 0028832233 scopus 로고
    • Early initiating and promoting effects in 2-AAF-induced rat liver carcinogenesis: An immunohistochemical study
    • Hadjiolov, N., Bitsch, A., Neumann, H.-G., 1995. Early initiating and promoting effects in 2-AAF-induced rat liver carcinogenesis: an immunohistochemical study. Cancer Lett. 98, 39.
    • (1995) Cancer Lett. , vol.98 , pp. 39
    • Hadjiolov, N.1    Bitsch, A.2    Neumann, H.-G.3
  • 13
    • 0029944721 scopus 로고    scopus 로고
    • Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation
    • Hall, S.R., Campbell, L.E., Meek, D.W., 1996. Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation. Nucleic Acids Res. 24, 1119.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 1119
    • Hall, S.R.1    Campbell, L.E.2    Meek, D.W.3
  • 14
    • 0029922621 scopus 로고    scopus 로고
    • P53 Tumor suppressor gene: From the basic research laboratory to the clinic-an abridged historical perspective
    • Harris, C., 1996. P53 Tumor suppressor gene: from the basic research laboratory to the clinic-an abridged historical perspective. Carcinogenesis 17, 1187.
    • (1996) Carcinogenesis , vol.17 , pp. 1187
    • Harris, C.1
  • 15
    • 0024592297 scopus 로고
    • Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism
    • Haystead, T.A.J., Sim, A.T.R., Carling, D., et al., 1989. Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337, 78.
    • (1989) Nature , vol.337 , pp. 78
    • Haystead, T.A.J.1    Sim, A.T.R.2    Carling, D.3
  • 16
    • 0029864618 scopus 로고    scopus 로고
    • Complex regulation of the DNA-binding activity of p53 by phosphorylation: Differential effects of individual phosphorylation sites on the interaction with different binding motivs
    • Hecker, D., Page, G., Lohrum, M., Weiland, S., Scheidtmann, K.H., 1996. Complex regulation of the DNA-binding activity of p53 by phosphorylation: differential effects of individual phosphorylation sites on the interaction with different binding motivs. Oncogene 12, 953.
    • (1996) Oncogene , vol.12 , pp. 953
    • Hecker, D.1    Page, G.2    Lohrum, M.3    Weiland, S.4    Scheidtmann, K.H.5
  • 18
    • 0025277669 scopus 로고
    • Constitutive phosphorylation of the receptor for insulin-like growth factor 1 in cells transformed by the src oncogene
    • Kozma, L.M., Weber, M.J., 1990. Constitutive phosphorylation of the receptor for insulin-like growth factor 1 in cells transformed by the src oncogene. Mol. Cell. Biol. 10, 3626.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 3626
    • Kozma, L.M.1    Weber, M.J.2
  • 19
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K., 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680.
    • (1970) Nature , vol.227 , pp. 680
    • Laemmli, U.K.1
  • 20
    • 0029097316 scopus 로고
    • Molecular controls of growth arrest and apoptosis: P53-dependent and independent pathways
    • Liebermann, D.A., Hoffman, B., Steinmann, A., 1995. Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways. Oncogene 11, 199.
    • (1995) Oncogene , vol.11 , pp. 199
    • Liebermann, D.A.1    Hoffman, B.2    Steinmann, A.3
  • 22
    • 0027332996 scopus 로고
    • Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
    • Lu, X., Lane, D., 1993. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell 75, 765.
    • (1993) Cell , vol.75 , pp. 765
    • Lu, X.1    Lane, D.2
  • 23
    • 0025904447 scopus 로고
    • Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis
    • Lucier, G.W., Tritscher, A., Goldsworthy, T., et al., 1991. Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis. Cancer Res. 51, 1391.
    • (1991) Cancer Res. , vol.51 , pp. 1391
    • Lucier, G.W.1    Tritscher, A.2    Goldsworthy, T.3
  • 24
    • 0021616838 scopus 로고
    • UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
    • Maltzman, W., Czyzyk, L., 1984. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol. 4, 1689.
    • (1984) Mol. Cell. Biol. , vol.4 , pp. 1689
    • Maltzman, W.1    Czyzyk, L.2
  • 25
    • 0024402595 scopus 로고
    • Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase
    • McConkey, D.J., Hartzell, P., Jondal, M., Orrenius, S., 1989. Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase. C. J. Biol. Chem. 264, 13399.
    • (1989) C. J. Biol. Chem. , vol.264 , pp. 13399
    • McConkey, D.J.1    Hartzell, P.2    Jondal, M.3    Orrenius, S.4
  • 26
    • 0029860159 scopus 로고    scopus 로고
    • DNA-damaging agents induce both p53-dependent and p53-independent apoptosis in immature thymocytes
    • McFarlane, M., Jones, N., Dive, C., Cohen, G., 1996. DNA-damaging agents induce both p53-dependent and p53-independent apoptosis in immature thymocytes. Mol. Pharmacol. 50, 900.
    • (1996) Mol. Pharmacol. , vol.50 , pp. 900
    • McFarlane, M.1    Jones, N.2    Dive, C.3    Cohen, G.4
  • 27
    • 0026786235 scopus 로고
    • Nuclear protein phosphorylation and growth control
    • Meek, D.W., Street, A., 1992. Nuclear protein phosphorylation and growth control. Biochem. J. 287, 1.
    • (1992) Biochem. J. , vol.287 , pp. 1
    • Meek, D.W.1    Street, A.2
  • 28
    • 0029993161 scopus 로고    scopus 로고
    • Murine p53 is phosphorylated within the Pab421 epitope by protein kinase C in vitro, but not in vivo, even after stimulation with the phorbol ester o-tetradecanoylphorbol 13-acetate
    • Milne, D.M., McKenderick, L., Jardine, L.J., et al., 1996. Murine p53 is phosphorylated within the Pab421 epitope by protein kinase C in vitro, but not in vivo, even after stimulation with the phorbol ester o-tetradecanoylphorbol 13-acetate. Oncogene 13, 205.
    • (1996) Oncogene , vol.13 , pp. 205
    • Milne, D.M.1    McKenderick, L.2    Jardine, L.J.3
  • 29
    • 0027922810 scopus 로고
    • Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction
    • Nebert, D.W., Puga, A., Vasiliou, V., 1993. Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction. Ann. N.Y. Acad. Sci. 685, 624.
    • (1993) Ann. N.Y. Acad. Sci. , vol.685 , pp. 624
    • Nebert, D.W.1    Puga, A.2    Vasiliou, V.3
  • 30
    • 0028177936 scopus 로고
    • Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver
    • Neveu, M.J., Hully, J.R., Babcock, K.L., et al., 1994. Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver. J. Cell Sci. 107, 83.
    • (1994) J. Cell Sci. , vol.107 , pp. 83
    • Neveu, M.J.1    Hully, J.R.2    Babcock, K.L.3
  • 31
    • 0026769457 scopus 로고
    • Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1
    • Oberhammer, F.A., Pavelka, M., Sharma, S., et al., 1992. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc. Natl. Acad. Sci. USA 89, 5408.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5408
    • Oberhammer, F.A.1    Pavelka, M.2    Sharma, S.3
  • 32
    • 0019230565 scopus 로고
    • The stages of initiation and promotion in hepatocarcinogenesis
    • Pitot, H.C., Sirica, A.E., 1980. The stages of initiation and promotion in hepatocarcinogenesis. Biochim. Biophys. Acta 605, 191.
    • (1980) Biochim. Biophys. Acta , vol.605 , pp. 191
    • Pitot, H.C.1    Sirica, A.E.2
  • 33
    • 0018932459 scopus 로고
    • Quantitative evalution of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethynitrosamine
    • Pitot, H.C., Goldsworthy, T., Campbell, H.A., Poland, A., 1980. Quantitative evalution of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethynitrosamine. Cancer Res. 40, 3616-3620.
    • (1980) Cancer Res. , vol.40 , pp. 3616-3620
    • Pitot, H.C.1    Goldsworthy, T.2    Campbell, H.A.3    Poland, A.4
  • 34
    • 0019996971 scopus 로고
    • Clonal growth of carcinogen-induced, enzyme-deficient preneoplastic cell populations in mouse liver
    • Rabes, H.M., Bücher, T., Hartmann, A., Linke, I., Dünnwald, M., 1982. Clonal growth of carcinogen-induced, enzyme-deficient preneoplastic cell populations in mouse liver. Cancer Res. 42, 3220.
    • (1982) Cancer Res. , vol.42 , pp. 3220
    • Rabes, H.M.1    Bücher, T.2    Hartmann, A.3    Linke, I.4    Dünnwald, M.5
  • 35
    • 0030864507 scopus 로고    scopus 로고
    • Polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin induce intrachromosomal recombination in vitro and in vivo
    • Schiestl, R.H., Aubrecht, J., Yap, W.Y., Kandikonda, S., Sidhom, S., 1997. Polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin induce intrachromosomal recombination in vitro and in vivo. Cancer Res. 57, 4378.
    • (1997) Cancer Res. , vol.57 , pp. 4378
    • Schiestl, R.H.1    Aubrecht, J.2    Yap, W.Y.3    Kandikonda, S.4    Sidhom, S.5
  • 36
    • 0026550571 scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin and ethinylestradiol as comitogens in cultured rat hepatocytes
    • Schrenk, D., Karger. A., Lipp, H.-P., Bock, K.W., 1992. 2,3.7.R-Tetrachlorodibenzo-p-dioxin and ethinylestradiol as comitogens in cultured rat hepatocytes. Carcinogenesis 13, 453.
    • (1992) Carcinogenesis , vol.13 , pp. 453
    • Schrenk, D.1    Karger, A.2    Lipp, H.-P.3    Bock, K.W.4
  • 37
    • 0028105722 scopus 로고
    • Promotion of preneoplastic foci in rat liver with 2,3,7,8-tetrachlordibenzo-p-dioxin, 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin and a defined mixture of 49 polychlorinated dibenzo-p-dioxins
    • Schrenk, D., Buchmann, A., Dietz, K., et al., 1994. Promotion of preneoplastic foci in rat liver with 2,3,7,8-tetrachlordibenzo-p-dioxin, 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin and a defined mixture of 49 polychlorinated dibenzo-p-dioxins. Carcinogenesis 15, 509.
    • (1994) Carcinogenesis , vol.15 , pp. 509
    • Schrenk, D.1    Buchmann, A.2    Dietz, K.3
  • 38
    • 0022414636 scopus 로고
    • Tumour promotion in the liver
    • Schulte-Hermann, R., 1985. Tumour promotion in the liver. Arch. Toxicol. 57, 147.
    • (1985) Arch. Toxicol. , vol.57 , pp. 147
    • Schulte-Hermann, R.1
  • 39
    • 0019475270 scopus 로고
    • Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin
    • Schulte-Hermann, R., Ohde, G., Schuppler, J., Timmermann-Trosiener, I., 1981. Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin. Cancer Res. 41, 2556.
    • (1981) Cancer Res. , vol.41 , pp. 2556
    • Schulte-Hermann, R.1    Ohde, G.2    Schuppler, J.3    Timmermann-Trosiener, I.4
  • 40
    • 0025032340 scopus 로고
    • DNA synthesis, apoptosis and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion
    • Schulte-Hermann, R., Timmermann-Trosiener, I., Barthel, G., Bursch, W., 1990. DNA synthesis, apoptosis and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. Cancer Res. 50, 5127.
    • (1990) Cancer Res. , vol.50 , pp. 5127
    • Schulte-Hermann, R.1    Timmermann-Trosiener, I.2    Barthel, G.3    Bursch, W.4
  • 41
    • 0028037663 scopus 로고
    • Tumor-promoting phorbol ester transiently down-modulates the p53 level and blocks the cell cycle
    • Skouv, J., Jensen, P.O., Forchhammer, J., Larsen, J.K., Lund, L.R., 1994. Tumor-promoting phorbol ester transiently down-modulates the p53 level and blocks the cell cycle. Cell Growth Diff. 5, 329.
    • (1994) Cell Growth Diff. , vol.5 , pp. 329
    • Skouv, J.1    Jensen, P.O.2    Forchhammer, J.3    Larsen, J.K.4    Lund, L.R.5
  • 42
    • 0029153263 scopus 로고
    • GST-P-positive hepatocytes isolated from rats bearing enzyme-altered foci show no signs of p53 protein induction and replicate even when their DNA contains strand breaks
    • Stenius, U., Högberg, J., 1995. GST-P-positive hepatocytes isolated from rats bearing enzyme-altered foci show no signs of p53 protein induction and replicate even when their DNA contains strand breaks. Carcinogenesis 16, 1683.
    • (1995) Carcinogenesis , vol.16 , pp. 1683
    • Stenius, U.1    Högberg, J.2
  • 43
    • 0029010526 scopus 로고
    • Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated tumour promotion in rat liver
    • Stinchcombe, S., Buchmann, A., Bock, K.W., Schwarz, M., 1995. Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated tumour promotion in rat liver. Carcinogenesis 16, 1271.
    • (1995) Carcinogenesis , vol.16 , pp. 1271
    • Stinchcombe, S.1    Buchmann, A.2    Bock, K.W.3    Schwarz, M.4
  • 44
    • 0027382021 scopus 로고
    • Association of insulin-like growth-factor-I-induced DNA synthesis with phosphorylation and nuclear exclusion of p53 in human breast cancer MCF-7 cells
    • Takahashi, K., Suzuki, K., 1993. Association of insulin-like growth-factor-I-induced DNA synthesis with phosphorylation and nuclear exclusion of p53 in human breast cancer MCF-7 cells. Int. J. Cancer 55, 453.
    • (1993) Int. J. Cancer , vol.55 , pp. 453
    • Takahashi, K.1    Suzuki, K.2
  • 45
    • 0023750235 scopus 로고
    • Inhibition of radiation-induced apoptosis in vitro by tumor promoters
    • Tomei, L., Kanter, P., Wenner, C., 1988. Inhibition of radiation-induced apoptosis in vitro by tumor promoters. Biochem. Biophys. Res. Commun. 155, 324.
    • (1988) Biochem. Biophys. Res. Commun. , vol.155 , pp. 324
    • Tomei, L.1    Kanter, P.2    Wenner, C.3
  • 46
    • 0028318454 scopus 로고
    • Recovery from ultraviolet-induced growth arrest of primary rat hepatocytes by p53 antisense oligonucleotide treatment
    • Tsuji, K., Ogawa, K., 1994. Recovery from ultraviolet-induced growth arrest of primary rat hepatocytes by p53 antisense oligonucleotide treatment. Mol. Carcinog. 9, 167.
    • (1994) Mol. Carcinog. , vol.9 , pp. 167
    • Tsuji, K.1    Ogawa, K.2
  • 48
    • 0017608939 scopus 로고
    • A review of the genetic toxicology of chlorinated dibenzo-p-dioxins
    • Wassom, J.S., Huff, J.E., Loprieno, N.A., 1977. A review of the genetic toxicology of chlorinated dibenzo-p-dioxins. Mutat. Res. 47, 141.
    • (1977) Mutat. Res. , vol.47 , pp. 141
    • Wassom, J.S.1    Huff, J.E.2    Loprieno, N.A.3
  • 49
    • 0028915836 scopus 로고
    • Accumulation of p53 protein in chemically induced oval cells during early stages of rodent hepatocarcinogenesis
    • Wirnitzer, U., Enzmann, H., Rosenbruch, M., Bomhard, E.M, 1995. Accumulation of p53 protein in chemically induced oval cells during early stages of rodent hepatocarcinogenesis. Carcinogenesis 16, 697.
    • (1995) Carcinogenesis , vol.16 , pp. 697
    • Wirnitzer, U.1    Enzmann, H.2    Rosenbruch, M.3    Bomhard, E.M.4
  • 50
    • 0029878895 scopus 로고    scopus 로고
    • Influence of liver tumor promoters on apoptosis in rat hepatocytes induced by 2-acetylaminofluorene, ultraviolet light or transforming growth factor β1
    • Wörner, W., Schrenk, D., 1996. Influence of liver tumor promoters on apoptosis in rat hepatocytes induced by 2-acetylaminofluorene, ultraviolet light or transforming growth factor β1. Cancer Res. 56, 1272.
    • (1996) Cancer Res. , vol.56 , pp. 1272
    • Wörner, W.1    Schrenk, D.2
  • 51
    • 0027177415 scopus 로고
    • Nicotine inhibition of apoptosis suggests a role in tumor promotion
    • Wright, S., Zhong, J., Zheng, H., Larrick, J., 1993. Nicotine inhibition of apoptosis suggests a role in tumor promotion. FASEB J. 7, 1045.
    • (1993) FASEB J. , vol.7 , pp. 1045
    • Wright, S.1    Zhong, J.2    Zheng, H.3    Larrick, J.4
  • 52
    • 0028361211 scopus 로고
    • Inhibition of apoptosis as a mechanism of tumor promotion
    • Wright, S., Zhong, J., Larrick, J., 1994. Inhibition of apoptosis as a mechanism of tumor promotion. FASEB J. 8, 654.
    • (1994) FASEB J. , vol.8 , pp. 654
    • Wright, S.1    Zhong, J.2    Larrick, J.3
  • 53
    • 0027439761 scopus 로고
    • Hyperphosphorylation of retinoblastoma protein and p53 by okadaic acid, a tumor promoter
    • Yatsunami, J., Komori, A., Ohta, T., Suganuma, M., Fujiki, H., 1993. Hyperphosphorylation of retinoblastoma protein and p53 by okadaic acid, a tumor promoter. Cancer Res. 53, 239.
    • (1993) Cancer Res. , vol.53 , pp. 239
    • Yatsunami, J.1    Komori, A.2    Ohta, T.3    Suganuma, M.4    Fujiki, H.5
  • 54
    • 0028016179 scopus 로고
    • Hyperphosphorylation of p53 induced by okadaic acid attenuates its transcriptional activation function
    • Zhang, W., McClain, C., Gau, J.-P., Xiang-Yang, D.G., Deisseroth, A.B., 1994. Hyperphosphorylation of p53 induced by okadaic acid attenuates its transcriptional activation function. Cancer Res. 54, 4448.
    • (1994) Cancer Res. , vol.54 , pp. 4448
    • Zhang, W.1    McClain, C.2    Gau, J.-P.3    Xiang-Yang, D.G.4    Deisseroth, A.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.