Hyperthermic isolated limb perfusion with tumour necrosis factor-α and melphalan as palliative limb-saving treatment in patients with locally advanced soft-tissue sarcomas of the extremities with regional or distant metastases. Is it worthwhile?

Archives of Orthopaedic and Trauma Surgery

Volumn 118, Issue 1-2, 1998, Pages 70-74

  Olieman, A F T ^a   Van Ginkel, R J ^a   Molenaar, W M ^a   Schraffordt Koops, H ^a   Hoekstra, H J ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MELPHALAN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTERY RUPTURE; ARTERY THROMBOSIS; ARTICLE; CANCER GROWTH; CANCER RECURRENCE; CANCER SURGERY; CLINICAL ARTICLE; FEMALE; FOLLOW UP; HUMAN; HYPERTHERMIC THERAPY; ILIAC ARTERY; LIMB PERFUSION; LIMB SALVAGE; LYMPH NODE METASTASIS; MALE; MORBIDITY; MORTALITY; PRIORITY JOURNAL; SOFT TISSUE SARCOMA; WOUND INFECTION;

ADULT; AGED; ANTINEOPLASTIC AGENTS, ALKYLATING; ARM; CHEMOTHERAPY, CANCER, REGIONAL PERFUSION; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTHERMIA, INDUCED; LEG; MALE; MELPHALAN; MIDDLE AGED; NEOPLASM METASTASIS; PALLIATIVE CARE; SALVAGE THERAPY; SARCOMA; SOFT TISSUE NEOPLASMS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032432389     PISSN: 09368051     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004020050314     Document Type: Article

References (35)

1. Baas PC, Schraffordt Koops H, Hoekstra HJ, Oosterhuis JW, Weele LT van der, Oldhoff J (1988) Isolated regional perfusion in the treatment of local recurrence, satellitosis and intransit metastasis of the extremities. Reg Cancer Treat 1:33-36
2. Beatres OH, Henson DE, Huttec RV, Meyers MH (1988) Manual for staging of cancer. J.B. Lippincott, Philadelphia, pp 127-133
3. Bramwell V, Rouesse J, Steward W, Santoro A, Schraffordt-Koops H, Buesa J, Ruka W, Priario J, Wagener T, Burgers M, et al (1994) Adjuvant CYVADIC chemotherapy for adult soft tissue sarcoma - reduced local recurrence but no improvement in survival: a study of the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J Clin Oncol 12:1137-1149
4. Casson AG, Putnam JB, Natarajan G (1992) Five year survival after pulmonary metastasectomy for adult soft tissue sarcoma. Cancer 69:662-668
5. Chang AE, Sondak VK (1995) Clinical evaluation and treatment of soft tissue tumors. In: Enzinger FM, Weiss SW (eds) Soft tissue tumours, 3rd edn. C.V. Mosby, St Louis, pp 17-31
6. Creech OJ, Krementz ET, Ryan RF, Winblad JN (1958) Chemotherapy of cancer: regional perfusion utilizing an extracorporal circuit. Ann Surg 148: 616-632
7. Eggermont AMM, Schraffordt Koops H, Klausner J, Kroon BBR, Schlag PM, Lienard D, et al (1996) Isolated limb perfusion with tumour necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience. Ann Surg 224:756-765
8. Eggermont AMM, Schraffordt Koops H, Lienard D, Kroon BBR, Geel AN van, Hoekstra HJ, Lejeune FJ (1996) Isolated limb perfusion with high dose tumour necrosis factor-α in combination with interferon-γ and melphalan for nonresectable extremity soft tissue sarcomas: a multicenter trial. J Clin Oncol 14:2653-2665
9. Fong Y, Coit DG, Woodruff JM, Brennan MF (1993) Lymph node metastases from soft tissue sarcoma in adults. Analysis of data from a prospective database of 1772 sarcoma patients. Ann Surg 217:72-77
10. Fontijne WP, Mook PH, Schraffordt Koops H, Oldhoff J, Wildevuur CR (1985) Improved tissue perfusion during pressure regulated regional perfusion: a clinical study. Cancer 55: 1456-1461
11. Gadd MA, Casper ES, Woodruff JM, McCormack PM, Brennan MF (1993) Development and treatment of pulmonary metastases in adult patients with extremity soft tissue sarcoma. Ann Surg 218:705-712
12. Ginkel RJ van, Hoekstra HJ, Eggermont AMM, Pras E, Schraffordt Koops H, et al (1996) Isolated limb perfusion with TNF, interferon and melphalan of an irradiated foot: a dramatic local effect. Arch Surg 131: 672-674
13. Ginkel RJ van, Hoekstra HJ, Pruim J, Nieweg OE, Molenaar WM, Paans AMJ, et al (1996) FDG PET to evaluate the response to hyperthermic isolated limb perfusion for locally advanced soft tissue sarcoma. J Nucl Med 37:984-990
14. Ginkel RJ van, Schraffordt Koops H, Vries EGE de, et al (1996) Hyperthermic isolated limb perfusion with cis-platin for sarcomas of soft tissue and bone. Eur J Surg 22: 528-531
15. Gutman M, Inbar M, Lev-Shlush D, Abu-Abid S, Mozes M, Chaitchik S, et al. (1997) High dose tumor necrosis factor-α and melphalan administered via isolated limb perfusion for advanced limb soft tissue sarcoma results in a > 90% response rate and limb preservation. Cancer 79:1129-1137
16. Hoekstra HJ, Schraffordt Koops H, Molenaar WM, Oldhoff J (1987) Results of isolated regional perfusion in the treatment of malignant soft tissue tumours of the extremities. Cancer 60: 1703-1707
17. Hoekstra HJ, Naujocks T, Schraffordt Koops H, Beekhuis H, Van Groningen Stuling R, Ter Veen H, et al (1992) Continuous leakage monitoring during hyperthermic isolated regional perfusion of the lower limb: technique and results. Reg Cancer Treat 4:301-304
18. Hoekstra HJ, Schraffordt Koops H, Oldhoff J (1994) Soft tissue sarcoma of the extremity. Eur J Surg Oncol 20:3-6
19. Hogeboom WR, Hoekstra HJ, Mooyaart EL, Freling NJM, Schraffordt Koops H (1991) MRI or CT in the preoperative evaluation of soft tissue tumors. Arch Orthop Trauma Surg 110: 162-164
20. Lehti PM, Mosely HS, Janoff K, Stevens K, Fletcher WS (1986) Improved survival for soft tissue sarcoma of the extremities by regional hyperthermic perfusion, local excision and radiation therapy. Surg Gynecol Obstet 162:149-152
21. Lienard D, Delmotte JJ, Renard N, Ewalenko P, Lejeune FJ (1992) High-dose recombinant tumour necrosis factor-alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma. J Clin Oncol 10:52-60
22. Mazanet R, Antman KH (1991) Sarcomas of soft tissue and bone. Cancer 68:463-473
23. Molenaar WM, Berg E van den, Dolfin AC, Zorgdrager H, Hoekstra HJ (1995) Cytogenetics of fine needle aspiration biopsies of sarcomas. Cancer Genet Cytogenet 84:27-31
24. Nieweg OE, Pruim J, Hoekstra HJ, Paans AMJ, Vaalburg W, Oldhoff J, et al (1994) Positron emission tomography with fluorine-18-fluorodeoxygenase for the evaluation of therapeutic isolated regional limb perfusion in a patient with soft tissue sarcoma. J Nucl Med 35:90-92
25. Olieman AFT, Ginkel RJ van, Hoekstra HJ, Mooyaart EE, Molenaar WM, Schraffordt Koops H (1997) The angiographic response of locally advanced soft tissue sarcoma following hyperthermic isolated limb perfusion with tumor necrosis factor. Ann Surg Oncol 4:64-69
26. Olieman AFT, Pras E, Ginkel RJ van, Molenaar WM, Schraffordt Koops H, Hoekstra HJ (1998) Feasibility and efficacy of external beam radiotherapy after hyperthermic isolated limb perfusion with TNF-α, IFN-γ and melphalan for limb saving treatment in locally advanced extremity soft tissue sarcoma. Int J Rad Oncol Biol Phys 40:807-814
27. Pan M, Wasa M, Lind S, Gertler J, Abbott W, Suoba W (1995) TNF-stimulated arginine transport by human endothelium requires activation of protein kinase C. Ann Surg 221:590-601
28. Pavy JJ, Denekamp J, Letschert B, Littbrand F, Mornex J, Bernier J, et al (1995) Late effects toxicity scoring: the SOMA scale. Radiother Oncol 35:11-15
29. Pisters PWT, Leung DH, Woodruff J, Shi W, Brennan MF (1990) Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol 14:1679-1689
30. Potter DA, Glenn J, Kinsella T, Glatstein E, Lack EE, Restrepo C, White DE, Seipp CA, Wesley R, Rosenberg SA (1985) Patterns of recurrence in patients with high-grade soft-tissue sarcomas. J Clin Oncol 3:353-366
31. Renard N, Lienard D, Lespagnard L, Eggermont A, Heiman R, Lejeune F (1994) Early endothelium activation and polymorphonuclear cell invasion precede specific necrosis of human melanoma and sarcoma treated by intravascular high-dose tumour necrosis factor alpha (rTNFα). Int J Cancer 57:656-663
32. Schraffordt Koops H, Oldhoff J, Oosterhuis JW, Beekhuis J (1987) Isolated regional perfusion in malignant melanoma of the extremities. World J Surg 11: 527-533
33. Trojani M, Contesso G, Coindre JM, Goussot JF, David M, Bonichon F, Lagare C (1984) Soft-tissue sarcomas of adults; study of pathologic variables and definition of a histopathological grading system. Int J Cancer 33:37-42
34. Weingrad DN, Rosenberg SA (1978) Early lymphatic spread of osteogenic and soft-tissue sarcomas. Surgery 84:231-240
35. Wingo PA, Tong T, Bolder S (1995) Cancer statistics. CA Cancer J Clin 45:8-30