Efficacy and tolerance of lysine clonixinate versus paracetamol/codeine following inguinal hernioplasty

International Journal of Tissue Reactions

Volumn 20, Issue 2, 1998, Pages 71-81

  De Los Santos, A R ^a,b   Di Girolamo, G ^a   Marti M L ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b NONE   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CLONIXIN LYSINE; COCODAMOL; CYCLOOXYGENASE 2;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERANCE; ENZYME INHIBITION; EPIGASTRIC PAIN; FEMALE; HEADACHE; HERNIOPLASTY; HUMAN; INGUINAL HERNIA; MALE; POSTOPERATIVE PAIN; RANDOMIZED CONTROLLED TRIAL;

ACETAMINOPHEN; ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; CLONIXIN; CODEINE; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FEMALE; HERNIA, INGUINAL; HUMANS; LYSINE; MALE; MIDDLE AGED; PAIN, POSTOPERATIVE; PROSPECTIVE STUDIES;

EID: 0032432019     PISSN: 02500868     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Vane J.R., Botting R.M. The mode of action of anti-inflammatory drugs. Postgrad. Med. J., 66 (Suppl. 4), S2, 1990.
2. Vane J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature, 231, 232, 1971.
3. Ferreira S.H., Moncada S., Vane J.R. Indomethacin and aspirin abolish prostaglandin release from spleen. Nature, 231, 237, 1971.
4. Ferreira S.H. Peripheral analgesia: mechanism of the analgesic action of aspirin-like drugs and opiate-antagonists. Br. J. Clin. Pharmacol., 10, 237S, 1980.
5. Hemler M., Lands W.E.M., Smith W.L. Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme. J. Biol. Chem., 251, 2629, 1976.
6. Smith W.L. Prostanoid biosynthesis and mechanism of action. Am. J. Physiol., 26B: F181-F191, 1992.
7. Akarasereenont P., Mitchell J.A., Bakhle Y.S., Thiemermann C., Vane J.R. Comparison of the induction of cyclooxygenase and nitric oxide synthase by endotoxin in endothelial cells and macrophages. Eur. J. Pharmacol., 273, 121, 1995.
8. Arias-Negrette S., Keller K., Chadee K. Proinflammatory cytokines regulate cyclooxygenase-2 mHNA expression in human macrophages. Biochem. Biophys. Res. Commun., 208, 582, 1995.
9. Crofford L.J., Wilder R.L., Ristimäki A.P., et al. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interteukin-1β, phorbol ester, and corticosteroids. Clin. Invest., 93, 1095, 1994.
10. Frölich J.C. A classification of nonsteroidal antiinflammatory drugs according to the relative inhibition of cyclooxygenase isoenzymes. TIPS, 18 (1), 30, 1997.
11. Ferrari P.N., Gallo Pecca J., Martinez M., Pico J.C. El clonixinato de lisina. I. Study on analgesic action (In Spanish). Communication to the 5th. Latin American Congress on Therapeutic Pharmacology, Lima, Peru, October 1974.
12. Ferrari P.N., Gallo Pecca J., Martinez M., Pico J.C. Antiprostaglandin action of RL-104 (In Spanish). Communication to the 5th. Latin American Congress on Therapeutic Pharmacology, Lima, Peru, October 1974.
13. Franchi A., Di Girolamo G., de los Santos A.R., Marti M.L., Gimeno M. Lysine clonixinate (LC) inhibits 5-HETE production in human colon. 10th International Conference on Prostaglandins and Related Compounds, Vienna, Austria, September 22-27, 1996.
14. Franchi A., Di Girolamo G., de los Santos A.R., Marti M.L., Gimeno M. Effect of lysine clonixinate (LC) on cyclooxygenase (COX)-I and -II in rat lung and stomach preparations. Prostaglandis Leukot Essent Fatty Acids (In Press, 1998).
15. Franchi A., Di Girolamo G., de los Santos A.R., Marti M.L., Gimeno M. Effect of lysine clonixinate (LC) and indomethacin in vivo on cyclooxygenase-I (COX-I) and -II (COX-II) in rat lung and stomach preparations. 4th International Congress on Essential Fatty Acids and Eicoisanoids, Edinburgh, Scotland, July 20-24, 1997.