Anesthetic-induced structural changes in the nicotinic acetylcholine receptor

Toxicology Letters

Volumn 100-101, Issue , 1998, Pages 179-183

  Ryan, Stephen E ^a   Nguyen, Hoa P ^a   Baenziger, John E ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Anesthetics; Binding site; Carbamylcholine; Nicotinic acetylcholine receptor

Indexed keywords

ANESTHETIC AGENT; CARBACHOL; CINCHOCAINE; LOCAL ANESTHETIC AGENT; NICOTINIC RECEPTOR; PROPANOL;

BINDING SITE; CONFERENCE PAPER; DRUG RECEPTOR BINDING; INFRARED SPECTROSCOPY; NONHUMAN; PRIORITY JOURNAL; TORPEDO;

ANESTHETICS; ANIMALS; CARBACHOL; ELECTRIC ORGAN; PARASYMPATHOMIMETICS; PROTEIN CONFORMATION; RECEPTORS, NICOTINIC; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TORPEDO;

EID: 0032430085     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00183-0     Document Type: Conference Paper

References (12)

1. Arias, H.R., 1996. Luminal and non-luminal non-competitive inhibitor binding sites on the nicotinic acetylcholine receptor. Mol. Membr. Biol. 13, 1-17.
2. Baenziger, J.E., Miller, K.W., Rothschild, K.J., 1992a. Incorporation of the nicotinic acetylcholine receptor into planar multilamellar films: characterization by fluorescence and fourier transform infrared difference spectroscopy. Biophys. J. 61, 983-992.
3. Baenziger, J.E., Miller, K.W., McCarthy, M.P., Rothschild, K.J., 1992b. Probing conformational changes in the nicotinic acetylcholine receptor by Fourier transform infrared difference spectroscopy. Biophys. J. 62, 64-66.
4. Baenziger, J.E., Miller, K.W., Rothschild, K.J., 1993. Fourier transform infrared difference spectroscopy of the nicotinic acetylcholine receptor: evidence for specific protein struc-tural changes upon desensitization. Biochemistry 32, 5448-5454.
5. Baenziger, J.E., Chew, J.P., 1997. Desensitization of the nicotinic acetylcholine receptor mainly involves a structural change in solvent-accessible regions of the polypeptide backbone. Biochemistry 36, 3617-3624.
6. Blanchard, S.G., Elliot, J., Raferty, M.A., 1979. Interaction of local anesthetics with Torpedo californica membrane-bound acetylcholine receptor. Biochemistry 18, 5880-5885.
7. + ion fluxes. Biochemistry 23, 4023-4033.
8. Braiman, M.S., Rothschild, K.J., 1988. Fourier transform infrared techniques for probing membrane protein structure. Annu. Rev. Biophys. Chem. 17, 541-570.
9. Forman, S.A., Miller, K.W., 1989. Molecular sites of anesthetic action in postsynaptic nicotinic membranes. Trends Pharmacol. Sci. 10, 447-452.
10. Krodel, E.K., Beckman, R.A., Cohen, J.B., 1979. Identification of a local anesthetic binding site in nicotinic post-synaptic membranes isolated from Torpedo marmorata electric tissue. Mol. Pharmacol. 15, 294-312.
11. Meyer, H., 1899. Welche eigenschafte der anasthetica bedingt ihre norkitische wirkung? Naunyn-Schmiedeberg's Arch. Exp. Pathol. Pharmacol. 42, 109.
12. Ryan, S.E., Demers, C.N., Chew, J.P., Baenziger, J.E., 1996. Structural effects of neutral and anionic lipids on the nicotinic acetylcholine receptor. J. Biol. Chem. 271, 24590-24597.