Recombinant platelet factor 4, an angiogenic marker for human breast carcinoma

Anticancer Research

Volumn 18, Issue 6 A, 1998, Pages 4035-4041

  Borgström, Per ^a   Discipio, Richard ^b   Maione, Theodore E ^c  

^a SIDNEY KIMMEL CANCER CENTER   (United States)

^b La Jolla Experimental Medicine   (United States)

^c Repligen   (United States)

Author keywords

Angiogenesis marker; Angiostatic; Anti angiogenic; Breast carcinoma; Human; Intravital microscopy; Platelet factor 4; Skinfold; Tumor spheroid

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; HEPARIN; RECOMBINANT THROMBOCYTE FACTOR 4;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOMA; CANCER SCREENING; CANCER STAGING; CONTROLLED STUDY; ENDOTHELIUM; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IMAGING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BINDING; SKINFOLD; TUMOR SPHEROID;

ANIMALS; BREAST NEOPLASMS; ENDOTHELIUM, VASCULAR; FEMALE; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; INJECTIONS, INTRA-ARTERIAL; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; PLATELET FACTOR 4; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY; SKIN; TRANSPLANTATION, HETEROLOGOUS;

EID: 0032429979     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Sailors DM, Crabtree JD, Land RL, Rose WB, Burns RP, Barker DE: Needle localization for nonpalpable breast lesions. Am-Surg 60(3): 186-9, 1994.
2. Gautherie M, Haehnel P, Walter JP, Keith LG: Thermovascular changes associated with in situ and minimal breast cancers. Results of an ongoing prospective study after four years. J-Reprod-Med. 833-42, 1987
3. Folkman J: Angiogenesis. In: Biology of Endothelial Cells, E.A. Jaffe, Ed. (Nijhoff, Boston), 412-428, 1984.
4. Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4-6, 1990.
5. Chodak GW, Haudenschild C, Gittes RF and Folkman J: Angiogenic activity as a marker of neoplastic and of preneoplastic lesions of the human bladder. Ann Surg 192: 762-71, 1980.
6. Folkman J: In: XIth Congress of Thrombosis and Haemostasis (Verstraete, M, Vermylen, J, Liijnan, R and Amout, J, eds.) Leuven, Belgium: Leuven University Press 583-96, 1987.
7. Weidner N, Semple J and Folkman J: Tumor angiogenesis correlates with metastasis in invasive breast carcinoma. New Engl J Med 324: 1-8, 1991.
8. Hayes DF: Tumor markers for breast cancer. Ann-Oncol 4(10): 807-19, 1993.
9. Hansell P, Olofsson M, Maione M, Arfors K-E, and Borgstrom P: Differences in binding of platelet factor 4 to vascular endothelium in vivo and proliferating endothelial cells in vitro. Acta Physiol Scand 154: 449-459, 1995.
10. Hansell P, Maione TE and Borgstrom P: Selective binding of platelet factor 4 to regions of active angiogenesis in vivo. Am J Physiol 269: H829-36, 1995
11. Torres Filho IP, Hartley-Asp B and Borgstrom P: Quantitative angiogenesis in a syngeneic tumor spheroid model. Microvasc Res 49: 212-226, 1995.
12. Dehmer GJ, Fisher M, Tate, DA, Teo S, Bonnem E: Reversal of Heparin Anticoagulation by Recombinant Platelet Factor 4 in Humans. Circulation vol: 91, pp: 2188-2194, 1995.
13. Northfelt DW, Robles R, Lang W, Wagner B, Kahn J and Bonnem E: Multicenter Phase II Study of Intravenous (A/) Recombinant Platelet Factor 4 (rPF4 in AIDS-Related Kaposi's Sarcoma(AIDS-KS) Proceedings of the American Society of Clinical Oncologists (ASCO), vol 14, p. 288 (abstract), 1995.
14. Arap W, Pasqualini R, Ruoslathi E: Cancer Treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 279: 377-389, 1998.
15. Srivastava A, Laidler P, Davies RP, Horgan K and Hughes LE: The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. A quantitative histologic study. Am J Pathol 133(2): 419-23, 1988.
16. Weidner N, Caroll PR, Flax J, Blumenfeld W and Folkman J: Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol 143: 401-409, 1993.
17. Macchiarini P, Fontanini G, Hardin MJ, Squartini F and Angeletti CA: Relation of neovascularisation to metastasis of non-small-cell lung cancer. Lancet 340(8812): 145-6, 1992.