Recognition of bactericidal/permeability-increasing protein by perinuclear anti-neutrophil cytoplasmic antibody-positive sera from ulcerative colitis patients: Prevalence and clinical significance

Scandinavian Journal of Gastroenterology

Volumn 33, Issue 12, 1998, Pages 1284-1288

  Vecchi, Maurizio ^a   Sinico, A ^b   Bianchi, M B ^b   Radice, A ^b   Gionchetti, P ^b   Campieri, M ^b   De Franchis, R ^b  

^a Istituto di Medicina Interna   (Italy)

^b NONE

Author keywords

Anti neutrophil cytoplasmic antibodies; Autoantibodies; Bactericidal permeability increasing protein; Inflammatory bowel disease; Ulcerative colitis

Indexed keywords

BACTERICIDAL PERMEABILITY INCREASING PROTEIN; NEUTROPHIL CYTOPLASMIC ANTIBODY;

ADOLESCENT; ADULT; AGED; ANTIBODY DETECTION; ARTICLE; AUTOIMMUNITY; CHILD; COLITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; ILEITIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROCTOCOLECTOMY; ULCERATIVE COLITIS;

ADOLESCENT; ADULT; AGED; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIMICROBIAL CATIONIC PEPTIDES; BLOOD BACTERICIDAL ACTIVITY; BLOOD PROTEINS; CHILD; COLITIS, ULCERATIVE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED;

EID: 0032428570     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365529850172377     Document Type: Article

References (30)

1. van der Woude FJ, Rasmussen N, Lobatto S, Wiik A, Permin H, van es LA, et al. Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet 1985;1:425-9.
2. Savage COS, Winearls CG, Jones S, Marshall PD, Lockwood CM. Prospective study of radioimmunoessay for antibodies directed against neutrophil cytoplasm in diagnosis of systemic vasculitis. Lancet 1987;1:1389-93.
3. Falk RJ, Jennette JC. Antineutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 1988;318:1651-7.
4. Saxon A, Shanahan F, Landers C, Ganz T, Targan S. A distinct subset of anti-neutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol 1990;86:202-10.
5. Rump JA, Scholmerich J, Gross V, Roth M, Helfesrieder R, Rautmann A, et al. A new type of perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) in active ulcerative colitis but not in Crohn's disease. Immunobiology 1990;181:406-13.
6. Duerr RH, Targan S, Landers C, Sutherland LR, Shanahan F. Anti-neutrophil cytoplasmic antibodies in ulcerative colitis. Comparison with other colitides/diarrheal ilnesses. Gastroenterology 1991;100:1590-6.
7. Colombel JF, Reumaux D, Duthilleul P, Noel LH, Gower-Rousseau C, Paris JC, et al. Anti-neutrophil cytoplasmic autoantibodies in inflammatory bowel diseases. Gastroenterol Clin Biol 1992;16:656-60.
8. Oudkerk Pool M, Ellerbroek PM, Ridwan BU, Goldschmeding R, von Blomberg BM, Pena AS, et al. Serum anti-neutrophil cytoplasmic autoantibodies in inflammatory bowel disease are mainly associated with ulcerative colitis: a correlation study between perinuclear antineutrophil cytoplasmic autoantibodies and clinical parameters, medical, and surgical treatment. Gut 1993;34:46-50.
9. Cambridge G, Rampton DS, Stevens TR, McCarthy DA, Kamm M, Leaker B. Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut 1992;33:668-74.
10. Seibold F, Weber P, Klein R, Berg PA, Wiedmann KH. Clinical significance of antibodies against neutrophils in patients with inflammatory bowel disease and primary sclerosing cholangitis. Gut 1992;33:657-62.
11. Hardarson S, Labrecque DR, Mitros FA, Neil GA, Goeken JA. Anti-neutrophil cytoplasmic antibody in inflammatory bowel and hepatobiliary diseases: high prevalence in ulcerative colitis, primary sclerosing cholangitis and autoimmune hepatitis. Am J Clin Pathol 1993;92:77-81.
12. Vecchi M, Bianchi MB, Sinico RA, Radice A, Meucci G, Torgano G, et al. Antibodies to neutrophil cytoplasm in Italian patients with ulcerative colitis: sensitivity, specificity and recognition of putative antigens. Digestion 1994;55:34-9.
13. Lesavre P. Antineutrophil cytoplasmic autoantibodies antigen specificity. Am J Kidney Dis 1991;18:159-63.
14. Hagen EC, Ballieux EPB, van Es LA, Daha MR, van der Woude FJ. Antineutrophil cytoplasmic antibodies: a review of the antigens involved, the assays, and the clinical and possible pathogenetic consequences. Blood 1993;81:1996-2002.
15. Halbwachs-Mecarelli L, Nusbaum P, Noel LH, Reumaux D, Erlinger S, Grunfeld JP. Anti-neutrophil cytoplasmic antibodies (ANCA) directed against cathepsine G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis. Clin Exp Immunol 1992;90:79-84.
16. Peen E, Almer S, Bodemar G, Ryden BO, Sjiolin C, Tejle K. Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis and Crohn's disease. Gut 1993;34:56-62.
17. Kossa K, Coulthart A, Ives CT, Pusey CD, Hodgson HJF. Antigen specificity of circulating anti-neutrophil cytoplasmic antibodies in inflammatory bowel disease. Eur J Gastroenterol Hepatol 1995;7:783-9.
18. Nassberger L, Ljungh A, Schumacher G, Kollberg B. Betaglucuronidase antibodies in ulcerative colitis. Lancet 1992;340: 734-5.
19. Zhao MH, Jones SJ, Lockwood CM. Bactericidal/permeability-increasing protein (BPI) is an important antigen for antineutrophil cytoplasmic autoantibodies (ANCA) in vasculitis. Clin Exp Immunol 1995;99:49-56.
20. Zhao MH, Jayne DRW, Arilles LG, Culley F, Hodson ME, Lockwood CM. Autoantibodies against bactericidal/permeability-increasing protein in patients with cystic fibrosis. Q J Med 1996;89:259-65.
21. Monajemi H, Meenan J, Lamping R, Obradov DO, Radema SA, Trown PW, et al. Inflammatory bowel disease is associated with increased mucosal levels of bactericidal/permeability-increasing protein. Gastroenterology 1996;110:733-9.
22. Stoffell MP, Csernok E, Herzberg C, Johnston T, Carroll SF, Gross WL. Anti-neutrophil cytoplasmic antibodies (ANCA) directed against bactericidal/permeability increasing protein (BPI): a new seromarker for inflammatory bowel disease and associated disorders. Clin Exp Immunol 1996;104:54-9.
23. Walmsley RS, Zhao MH, Hamilton MI, Brownlee A, Chapman P, Pounder RE, et al. Antineutrophil cytoplasm autoantibodies against bactericidal/permeability-increasing protein in inflammatory bowel disease. Gut 1997;40:105-9.
24. Sandborn WJ, Tremaine WJ, Batts KP, Pemberton JH, Phillips SF. Pouchitis after ileal pouch-anal anastomosis: a Pouchitis Disease Activity Index. Mayo Clin Proc 1994;69:409-15.
25. Seibold F, Slametschka D, Gregor M, Weber P. Neutrophil autoantibodies: a genetic marker in primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 1994;107:532-6.
26. Jones SJ, Zhao MH, Elliott JD, Lockwood CM. The antigenicity of bactericidal/permeability increasing protein (BPI) is threatened by serine proteases. Clin Exp Immunol 1995;101 Suppl 1:36.
27. Sandborn WJ, Landers CJ, Tremaine WJ, Targan SR. Association of antineutrophil cytoplasmic antibodies with resistance to treatment of left-sided ulcerative colitis: results of a pilot study. Mayo Clin Proc 1996;71:431-6.
28. Vecchi M, Bianchi MB, Calabresi C, Meucci G, Tatarella M, de Franchis R. Long-term observation of the perinuclear antineutrophil cytoplasmic antibody status in ulcerative colitis patients. Scand J Gastroenterol 1998;33:170-3.
29. Vecchi M, Gionchetti P, Bianchi MB, Belluzzi A, Meucci G, Campieri M, et al. p-ANCA and development of pouchitis in ulcerative colitis patients after proctocolectomy and ileoanal pouch anastomosis [letter]. Lancet 1994;344:886-7.
30. Sandborn WJ, Landers CJ, Tremaine WJ, Targan SR. Antineutrophil cytoplasmic antibody correlates with chronic pouchitis after ileal pouch-anal anastomosis. Am J Gastroenterol 1995;90:740-7.