Systemic administration of rIL-12 synergistically enhances the therapeutic effect of a TNF gene-transduced cancer vaccine

Gene Therapy

Volumn 5, Issue 12, 1998, Pages 1677-1684

  Taniguchi, F ^a   Yamagishi, H ^a   Fujiwara, H ^a   Ueda, Y ^a   Fuji, N ^a   Yoshimura, T ^a   Oka, T ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Adjuvant; Cancer vaccine; Gene therapy; rIL 12; TNF

Indexed keywords

CANCER VACCINE; CYTOKINE; GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 12; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER IMMUNIZATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; FIBROSARCOMA; GENE THERAPY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALIA; MURINAE;

EID: 0032428469     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300779     Document Type: Article

References (6)

1. Asher AL et al. Murine tumor cells transduced with the gene for tumor necrosis factor-α. Evidence for paracrine immune effects of tumor necrosis factor against tumors. J Immunol 1991; 146: 3227-3234.
2. Fearon ER et al. Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell 1990; 60: 397-403.
3. Gansbacher B et al. Retroviral vector-mediated γ-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity. Cancer Res 1990; 50: 7820-7825.
4. Porgador A et al. Combined vaccination with major histocompatibility class I and interleukin 2 gene-transduced melanoma cells synergizes the cure of postsurgical established lung metastases. Cancer Res 1995; 55: 4941-4949.
5. + T cells by B7-transfected melanoma cells. Science 1993; 259: 368-370.
6. Connor J et al. Regression of bladder tumors in mice treated with interleukin 2 gene-modified tumor cells. J Exp Med 1993; 177: 1127-1134.