Effects of moguisteine on the cough reflex induced by afferent electrical stimulation of the superior laryngeal nerve in guinea pigs

European Journal of Pharmacology

Volumn 362, Issue 2-3, 1998, Pages 207-212

  Ishii, Ritsuko ^a   Furuta, Motoko ^a   Hashimoto, Masayo ^a   Naruse, Tomohiro ^a   Gallico, Licia ^b   Ceserani, Roberto ^b  

^a Maruho Co   (Japan)

^b Boehringer Ingelheim Italia SpA   (Italy)

Author keywords

Antitussive drug; Codeine; Cough; Moguisteine; Naloxone; Superior laryngeal nerve

Indexed keywords

CODEINE; CODEINE PHOSPHATE; MOGUISTEINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COUGHING; FEMALE; GUINEA PIG; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LARYNGEAL NERVE; NONHUMAN; PRIORITY JOURNAL;

AEROSOLS; ANIMALS; ANTICOAGULANTS; ANTITUSSIVE AGENTS; CITRIC ACID; CODEINE; COUGH; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; FEMALE; GUINEA PIGS; INJECTIONS, INTRAVENOUS; INJECTIONS, INTRAVENTRICULAR; LARYNGEAL NERVES; REFLEX; THIAZOLES; THIAZOLIDINES;

EID: 0032425897     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00760-2     Document Type: Article

References (17)

1. Charlier R., Prost M., Binon F., Deltour G. Etude pharmacologique d'un antitussif, le fumarate acide de phenethyl-1 (propyne-2-yl)-4 propionoxy-4 piperidine. Arch. Int. Pharmacodyn. 84:1961;306-327.
2. Domenjoz R. Zur Auswertung hustenstillender Arzneimittel. Arch. Exp. Pathol. Pharmakol. 215:1952;19-24.
3. Gallico L., Borghi A., Dalla Rosa C., Ceserani R., Tognella S. Moguisteine: a novel peripheral non-narcotic antitussive drug. Br. J. Pharmacol. 112:1994;795-800.
4. Kamei J., Hosokawa T., Yanaura S., Hukuhara T. Effects of methysergide on the cough reflex. Jpn. J. Pharmacol. 42:1986;450-452.
5. Kamei J., Hosokawa T., Yanaura S., Hukuhara T. Involvement of central serotonergic mechanisms in the cough reflex. Jpn. J. Pharmacol. 42:1986;531-538.
6. Kamei J., Hukuhara T., Kasuya Y. Dopaminergic control of the cough reflex as demonstrated by the effects of apomorphine. Eur. J. Pharmacol. 141:1987;511-513.
7. Karlsson J.-A., Sant'Ambrogio G., Widdicombe J. Afferent neural pathways in cough and reflex bronchoconstriction. J. Appl. Physiol. 65:1988;1007-1023.
8. Kase Y. Antitussive agents and their sites of action. TIPS. 5:1980;237-239.
9. Kase Y., Kawaguchi M., Takahama K., Miyata T., Hirotsu I., Hitoshi T., Okano Y. Pharmacological studies on DL-glycine phosphate as an antitussive. Arzneim.-Forsch. Drug Res. 33:1983;936-946.
10. Lavezzo A., Melillo G., Clavenna G., Omini C. Peripheral site of action of levodropropizine in experimentally-induced cough: Role of sensory neuropeptides. Pulm. Pharmacol. 5:1992;143-147.
11. Männistö P.T., Karttunen P., Lahovaara S., Nissinen E., Davies J.E., Algate D.R., Baines M.W. Antitussive action of the new anilide derivative vadocaine hydrochloride compared with codeine phosphate in four animal models. Arzneim.-Forsch. Drug Res. 38:1988;598-604.
12. Melillo G., Malandrino S., Rossoni G., Caselli G., Bestetti A., Borsa M., Tonon G.C., Berti F. General pharmacology of the new antitussive levodropropizine. Arzneim.-Forsch. Drug Res. 38:1988;1144-1150.
13. Morikawa T., Gallico L., Widdicombe J. Actions of moguisteine on cough and pulmonary rapidly adapting receptor activity in the guinea pig. Pharmacol. Res. 35:1997;113-118.
14. Rispat G., Burgi H., Cosnier D., Duchêne-Marullaz P., Streichenberger G. General pharmacological properties of a new non-opiate antitussive: Zipeprol (3024 CERM): I. Action on respiratory function and acute toxicity. Arzneim.-Forsch. Drug Res. 26:1976;523-530.
15. Sant'Ambrogio G., Sant'Ambrogio F.B. Action of moguisteine on the activity of tracheobronchial rapidly adapting receptors in the dog. Eur. Respir. J. 11:1998;339-344.
16. Shams H., Daffonchio L., Scheid P. Effects of levodropropizine on vagal afferent C-fibres in the cat. Br. J. Pharmacol. 117:1996;853-858.
17. Tarayre J.P., Vilain P., Lauressergues H., Cauquil J. Pharmacological study of the antitussive and respiratory-analeptic properties of N-(2′-ethylpyrrolidino)diphenyl-acetamide hydrochloride (F 1459). Arzneim.-Forsch Drug Res. 33:1983;931-935.