High concentrations of recombinant adenovirus expressing p16 gene induces apoptosis in lung cancer cell lines

Anticancer Research

Volumn 18, Issue 6 A, 1998, Pages 4275-4282

  Naruse, Ichiro ^a,b   Heike, Yuji ^a,c   Hama, Seiji ^a   Mori, Masatomo ^b   Saijo, Nagahiro ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b GUNMA UNIVERSITY   (Japan)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Apoptosis; Non small cell lung cancer; p16; Recombinant adenovirus

Indexed keywords

PROTEIN P16;

ADENOVIRUS; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL GROWTH; CELL KILLING; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL; TRANSGENE;

ADENOVIRUSES, HUMAN; APOPTOSIS; CELL DIVISION; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; HUMANS; IN SITU NICK-END LABELING; KINETICS; LUNG NEOPLASMS; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC; RETINOBLASTOMA PROTEIN; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032425707     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-7, 1993.
2. Lukas J, Party D, Aagaard L, Mann DJ, Bartkova J, Strauss M, et al: Retinoblastoma-protein-dependent cell-cycle inhibition by the tumor suppressor p16. Nature 375: 503-6, 1995.
3. Medema RH, Herrera RE, Lam F, Weinberg RA: Growth suppression by p16ink4 requires functional retinoblastoma protein. Proc. Natl. Acad. Sci. USA. 92: 6289-93, 1995.
4. Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA: Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368: 753-6, 1994.
5. Kamb A, Gruis NA, Weaver-Feldhaus J, Lui Q, Harshman K, Tavtigian SV, et al: A cell cycle regulator potentially involved in genesis of many tumor types. Science 264: 436-40, 1994.
6. Okamoto A, Demetrick DJ, Spillare EA, Hagiwara K, Hussain SP, Bennett WP, et al: Mutations and altered expression of p16ink4 in human cancer. Proc Natl Acad Sci USA 91: 11045-9, 1994.
7. Otterson GA, Kratzke RA, Coxon A, Kim YW, Kaye FJ: Absence of p16ink4 protein is restricted to the subset of lung cancer cell lines that retains the wildtype RB. Oncogene 9: 3375-8, 1994.
8. Jin X, Nguyen D, Zhang WW, Kyritsis AP, Roth JA: Cell cycle arrest and inhibition of tumor cell proliferation by the p16ink4 gene mediated by an adenovirus vector. Cancer Res 55: 3250-3, 1995.
9. Stone S, Dayananth P, Kamb A. Reversible, p16-mediated cell cycle arrest as protection from chemotherapy. Cancer Res 56: 3199-202, 1996.
10. Fueyo J, Gomez-Manzano C, Yung WK A, Clayman GL, Liu TJ, Bruner J, et al: Adenovirus-mediated p16/CDK2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells. Oncogene 12: 103-10, 1996.
11. Chanda PK, Natuk RJ, Mason BB, Bhat BM, Greenberg L,Dheer SK, et al: High level expression of the envelope glycoproteins of the human immunodeficiency virus type 1 in presence of rev gene using helper-independent adenovirus type 7 recombinants. Virology 175: 535-47, 1990.
12. Ragot T, Vincent N, Chafey P, Vigne E, Gilgenkrantz H, Couton D, et al: Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice. Nature 361: 647-50, 1993.
13. Zabner J, Couture LA, Gregory RJ, Graham SM, Smith AE, Welsh MJ: Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 75: 207-16, 1993.
14. Engelhardt JF, Simon RH, Yang Y, Zepeda M, Weber-Pendeleton S, Doranz B, et al: Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: biological efficacy study. Hum Gene Ther 4: 759-69, 1993.
15. Hama S, Heike Y, Naruse I, Takahashi M, Kurisu K, Saijo N. Adenovirus-mediated p16 gene transfer induces chemoresistance through G1 arrest in human glioma cells. Int J Cancer 77: 47-54, 1998.
16. Heike Y, Takahashi M, Kanegae Y, Sato Y, Saito I, Saijo N: Interleukin-2 gene transduction into freshly isolated lung adenocarcinoma cells with adenoviral vectors. Hum Gene Ther 8: 1-14, 1997.