메뉴 건너뛰기




Volumn 40, Issue 4, 1998, Pages 293-301

Physiologically based pharmacokinetic modeling of metabolic interactions between n-hexane and toluene in humans

Author keywords

Co exposure; Metabolic interaction; n Hexane; PBPK model; Toluene

Indexed keywords

HEXANE; SOLVENT; TOLUENE;

EID: 0032425047     PISSN: 13419145     EISSN: None     Source Type: Journal    
DOI: 10.1539/joh.40.293     Document Type: Article
Times cited : (18)

References (38)
  • 1
    • 0022612347 scopus 로고
    • n-Hexane and benzene contents in gasoline for industrial purpose
    • Ikeda M, Kasahara M. n-Hexane and benzene contents in gasoline for industrial purpose. Ind Health 1986; 24: 63-66.
    • (1986) Ind Health , vol.24 , pp. 63-66
    • Ikeda, M.1    Kasahara, M.2
  • 2
    • 0021037284 scopus 로고
    • A nationwide survey on organic solvent components in various solvent products. Part 1 Homogeneous products such as thinners, degreasers and reagents
    • Inoue T, Takeuchi Y, Hisanaga N, Ono Y, Iwata M, Ogata M, Saito K, Sakurai H, Hara I, Matsushita T and Ikeda M. A nationwide survey on organic solvent components in various solvent products. Part 1 Homogeneous products such as thinners, degreasers and reagents. Ind Health 1983; 21: 175-183.
    • (1983) Ind Health , vol.21 , pp. 175-183
    • Inoue, T.1    Takeuchi, Y.2    Hisanaga, N.3    Ono, Y.4    Iwata, M.5    Ogata, M.6    Saito, K.7    Sakurai, H.8    Hara, I.9    Matsushita, T.10    Ikeda, M.11
  • 3
    • 0021707393 scopus 로고
    • Changes of n-hexane neurotoxicity and its urinary metabolites by long term co-exposure with MEK or toluene
    • Iwata M, Takeuchi Y, Hisanaga N, Ono Y. Changes of n-hexane neurotoxicity and its urinary metabolites by long term co-exposure with MEK or toluene. Int Arch Occup Environ Health 1984; 54: 273-281.
    • (1984) Int Arch Occup Environ Health , vol.54 , pp. 273-281
    • Iwata, M.1    Takeuchi, Y.2    Hisanaga, N.3    Ono, Y.4
  • 4
    • 0021027127 scopus 로고
    • Changes of n-hexane metabolites in urine of rats exposed to various concentrations of n-hexane and to its mixture with toluene or MEK
    • Iwata M, Takeuchi Y, Hisanaga N, Ono Y. Changes of n-hexane metabolites in urine of rats exposed to various concentrations of n-hexane and to its mixture with toluene or MEK. Int Arch Occup Environ Health 1983; 53: 1-8.
    • (1983) Int Arch Occup Environ Health , vol.53 , pp. 1-8
    • Iwata, M.1    Takeuchi, Y.2    Hisanaga, N.3    Ono, Y.4
  • 5
    • 0025770536 scopus 로고
    • Effect of simultaneous exposure to toluene and xylene on their respective biological exposure indices in human
    • Tardif R, Goyal R, Brodeur J. Effect of simultaneous exposure to toluene and xylene on their respective biological exposure indices in human. Int Arch Occup Environ Health 1991; 63: 279-284.
    • (1991) Int Arch Occup Environ Health , vol.63 , pp. 279-284
    • Tardif, R.1    Goyal, R.2    Brodeur, J.3
  • 7
    • 0025274403 scopus 로고
    • Changes in urinary n-hexane metabolites by co-exposure to various concentrations of methyl ethyl ketone and fixed n-hexane levels
    • Shibata E, Huang J, Ono Y, Hisanaga N, Iwata M, Saito I, and Takeuchi Y. Changes in urinary n-hexane metabolites by co-exposure to various concentrations of methyl ethyl ketone and fixed n-hexane levels. Arch Toxicol 1990; 64: 165-168.
    • (1990) Arch Toxicol , vol.64 , pp. 165-168
    • Shibata, E.1    Huang, J.2    Ono, Y.3    Hisanaga, N.4    Iwata, M.5    Saito, I.6    Takeuchi, Y.7
  • 8
    • 0026545192 scopus 로고
    • Assessment of occupational health risk from multiple exposure: Review of industrial solvent interaction and implication for biological monitoring of exposure
    • Tardif R, Goyal R, and Brodeur J. Assessment of occupational health risk from multiple exposure: review of industrial solvent interaction and implication for biological monitoring of exposure. Toxicol Ind Health 1992; 8: 37-52.
    • (1992) Toxicol Ind Health , vol.8 , pp. 37-52
    • Tardif, R.1    Goyal, R.2    Brodeur, J.3
  • 10
    • 0021056199 scopus 로고
    • A nationwide survey on organic solvent components in various solvent products. Part 2 Heterogeneous products such as paints, inks and adhesives
    • Kumai M, Koizumi A, Saito K, Sakurai H, Inoue T, Takeuchi Y, Ogata M, Matsushita T and Ikeda M. A nationwide survey on organic solvent components in various solvent products. Part 2 Heterogeneous products such as paints, inks and adhesives. Ind Health 1983; 21: 185-197.
    • (1983) Ind Health , vol.21 , pp. 185-197
    • Kumai, M.1    Koizumi, A.2    Saito, K.3    Sakurai, H.4    Inoue, T.5    Takeuchi, Y.6    Ogata, M.7    Matsushita, T.8    Ikeda, M.9
  • 11
    • 0020712095 scopus 로고
    • Position specificity in n-hexane hydroxylation by two forms of cytochrome P 450 in rat liver microsomes
    • Morohashi K, Sadano H, Okada Y, Omura T. Position specificity in n-hexane hydroxylation by two forms of cytochrome P 450 in rat liver microsomes. J Biochem Tokyo 1983; 93: 413-419.
    • (1983) J Biochem Tokyo , vol.93 , pp. 413-419
    • Morohashi, K.1    Sadano, H.2    Okada, Y.3    Omura, T.4
  • 12
    • 0028670455 scopus 로고
    • Induction of cytochrome P450 by toluene
    • Nakajima T, Wang RS. Induction of cytochrome P450 by toluene. Int J Biochem 1994; 26: 1330-1340.
    • (1994) Int J Biochem , vol.26 , pp. 1330-1340
    • Nakajima, T.1    Wang, R.S.2
  • 13
    • 0023013619 scopus 로고
    • Rat lung and liver microsomal cytochrome P 450 isozymes involved in the hydroxylation of n-hexane
    • Toftgard R, Haaparanta T, Eng L, Halpert J. Rat lung and liver microsomal cytochrome P 450 isozymes involved in the hydroxylation of n-hexane. Biochem Pharmacol 1986; 35: 3733-3738.
    • (1986) Biochem Pharmacol , vol.35 , pp. 3733-3738
    • Toftgard, R.1    Haaparanta, T.2    Eng, L.3    Halpert, J.4
  • 14
    • 0026245362 scopus 로고
    • The effect of environmental factors on the pharmacokinetic behaviour of organic solvent vapours
    • Sato A. The effect of environmental factors on the pharmacokinetic behaviour of organic solvent vapours. Ann Occup Hyg 1991; 35: 525-541.
    • (1991) Ann Occup Hyg , vol.35 , pp. 525-541
    • Sato, A.1
  • 15
    • 0031979377 scopus 로고    scopus 로고
    • Metabolic interaction between toluene, trichloroethylene and n-hexane in humans
    • Bælum J, Mølhave L, Hansén SH, Væth M (1998) Metabolic interaction between toluene, trichloroethylene and n-hexane in humans. Scand J Work Environ Health 24: 30-37.
    • (1998) Scand J Work Environ Health , vol.24 , pp. 30-37
    • Bælum, J.1    Mølhave, L.2    Hansén, S.H.3    Væth, M.4
  • 16
    • 0021867932 scopus 로고
    • Coexposure to toluene and p-xylene in man: Uptake and elimination
    • Wallen M, Holm S, Byfalt Nordqvist B. Coexposure to toluene and p-xylene in man: uptake and elimination. Brit J Ind Med 1985; 42: 111-116.
    • (1985) Brit J Ind Med , vol.42 , pp. 111-116
    • Wallen, M.1    Holm, S.2    Byfalt Nordqvist, B.3
  • 17
    • 0024955880 scopus 로고
    • Excretion of Methylbenezoic acid in urine a result of single and combined exposure to m-xylene
    • Jacubowski M, kostrezewski P. Excretion of Methylbenezoic acid in urine a result of single and combined exposure to m-xylene. Pol J Occup Med 1986; 2: 238-247.
    • (1986) Pol J Occup Med , vol.2 , pp. 238-247
    • Jacubowski, M.1    Kostrezewski, P.2
  • 18
    • 0025739599 scopus 로고
    • Effects of consumption of ethanol on the biological monitoring of exposure to organic solvent vapours: Simulation study with trichloroethylene
    • Sato A, Endoh K, Kaneko T, Johanson G. Effects of consumption of ethanol on the biological monitoring of exposure to organic solvent vapours: simulation study with trichloroethylene. Brit J Ind Med 1991; 48: 548-556.
    • (1991) Brit J Ind Med , vol.48 , pp. 548-556
    • Sato, A.1    Endoh, K.2    Kaneko, T.3    Johanson, G.4
  • 19
    • 0027319124 scopus 로고
    • Physiologically based modelling of the toxicokinetic interaction between toluene and m-xylene in the rat
    • Tardif R, Lapare S, Krishnan K, and Brodeur J. Physiologically based modelling of the toxicokinetic interaction between toluene and m-xylene in the rat. Toxicol Appl Pharmacol 1993; 120: 266-273.
    • (1993) Toxicol Appl Pharmacol , vol.120 , pp. 266-273
    • Tardif, R.1    Lapare, S.2    Krishnan, K.3    Brodeur, J.4
  • 20
    • 0027828698 scopus 로고
    • A pharmacokinetic model to describe toxicokinetic interactions between 1,3-butadiene and styrene in rats: Predictions for human exposure
    • Filser JG, Johanson G, Kessler W, Kreuzer PE, Stei P, Baur C, Csanady GA. A pharmacokinetic model to describe toxicokinetic interactions between 1,3-butadiene and styrene in rats: predictions for human exposure. IARC Sci Publ 1993; 127: 65-78.
    • (1993) IARC Sci Publ , vol.127 , pp. 65-78
    • Filser, J.G.1    Johanson, G.2    Kessler, W.3    Kreuzer, P.E.4    Stei, P.5    Baur, C.6    Csanady, G.A.7
  • 21
    • 0022995670 scopus 로고
    • Physiologically based pharmacokinetic modeling of inhaled 2-butoxyethanol in man
    • Johanson G. Physiologically based pharmacokinetic modeling of inhaled 2-butoxyethanol in man. Toxicol Lett 1986; 34: 23-31.
    • (1986) Toxicol Lett , vol.34 , pp. 23-31
    • Johanson, G.1
  • 22
    • 0023031775 scopus 로고
    • Physiologicomathematical model for studying human exposure to organic solvents: Kinetics of blood/tissue n-hexane concentrations and of 2,5-hexanedione in urine
    • Perbellini L, Mozzo P, Brugnone F, Zedde. Physiologicomathematical model for studying human exposure to organic solvents: kinetics of blood/tissue n-hexane concentrations and of 2,5-hexanedione in urine. Brit J Ind Med 1986; 43: 760-768.
    • (1986) Brit J Ind Med , vol.43 , pp. 760-768
    • Perbellini, L.1    Mozzo, P.2    Brugnone, F.3    Zedde4
  • 23
    • 0025340345 scopus 로고
    • "Dynamic" biological exposure indexes for n-hexane and 2,5-hexanedione, suggested by a physiologically based pharmacokinetic model
    • Perbellini L, Mozzo P, Olivato D, Brugnone F. "Dynamic" biological exposure indexes for n-hexane and 2,5-hexanedione, suggested by a physiologically based pharmacokinetic model. Am Ind Hyg Assoc J 1990; 51: 356-362.
    • (1990) Am Ind Hyg Assoc J , vol.51 , pp. 356-362
    • Perbellini, L.1    Mozzo, P.2    Olivato, D.3    Brugnone, F.4
  • 24
    • 0021279862 scopus 로고
    • A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans
    • Ramsey JC, Andersen ME. A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol Appl Pharmacol 1984; 73: 159-175.
    • (1984) Toxicol Appl Pharmacol , vol.73 , pp. 159-175
    • Ramsey, J.C.1    Andersen, M.E.2
  • 25
    • 0019485517 scopus 로고
    • Structure and quantification of physiological model of the distribution of injected agents and inhaled anaesthetics
    • Davis MR, Mapleson WW. Structure and quantification of physiological model of the distribution of injected agents and inhaled anaesthetics. Brit J Anaesth 1981; 53: 399-405.
    • (1981) Brit J Anaesth , vol.53 , pp. 399-405
    • Davis, M.R.1    Mapleson, W.W.2
  • 26
    • 0021803133 scopus 로고
    • Partition coefficient of some industrial aliphatic hydrocarbons (C5-C7) in blood and human tissues
    • Perbellini L, Brugnone F, Caretta D, Maranelli G. Partition coefficient of some industrial aliphatic hydrocarbons (C5-C7) in blood and human tissues. Brit J Ind Med 1985; 42: 162-167.
    • (1985) Brit J Ind Med , vol.42 , pp. 162-167
    • Perbellini, L.1    Brugnone, F.2    Caretta, D.3    Maranelli, G.4
  • 27
  • 28
  • 31
    • 2442761494 scopus 로고
    • Toxicokinetic aspects of n-hexane and 2,5-hexanedione in the biomonitoring of occupational exposure to n-hexane
    • Perbellini L, Brugnone F, Mozzo P, De Rosa E, Bartolucci GB, Facinni G. Toxicokinetic aspects of n-hexane and 2,5-hexanedione in the biomonitoring of occupational exposure to n-hexane. Ann Am Conf Ind Hyg 1985; 12: 357-364.
    • (1985) Ann Am Conf Ind Hyg , vol.12 , pp. 357-364
    • Perbellini, L.1    Brugnone, F.2    Mozzo, P.3    De Rosa, E.4    Bartolucci, G.B.5    Facinni, G.6
  • 32
    • 0023921356 scopus 로고
    • Spreadsheet programming: A new approach in physiologically based modelling of solvent toxicokinetics
    • Johanson G, Näslund PH. Spreadsheet programming: a new approach in physiologically based modelling of solvent toxicokinetics. Toxicol Lett 1988; 41: 115-127.
    • (1988) Toxicol Lett , vol.41 , pp. 115-127
    • Johanson, G.1    Näslund, P.H.2
  • 33
    • 0020060726 scopus 로고
    • Experimental human exposure to n-hexane. Study of the respiratory uptake and elimination, and of n-hexane concentrations in peripheral venous blood
    • Veulemans H, Van Vlem E, Janssens H, Masschelein R, Leplat A. Experimental human exposure to n-hexane. Study of the respiratory uptake and elimination, and of n-hexane concentrations in peripheral venous blood. Int Arch Occup Environ Health 1982; 49: 251-263.
    • (1982) Int Arch Occup Environ Health , vol.49 , pp. 251-263
    • Veulemans, H.1    Van Vlem, E.2    Janssens, H.3    Masschelein, R.4    Leplat, A.5
  • 34
    • 0020029892 scopus 로고
    • Exposure to toluene, uptake, distribution and elimination in man
    • Carlsson A. Exposure to toluene, uptake, distribution and elimination in man. Scand J Work Environ Health 1982; 8: 43-55.
    • (1982) Scand J Work Environ Health , vol.8 , pp. 43-55
    • Carlsson, A.1
  • 35
    • 2442724267 scopus 로고
    • Relationship between n-hexane and urinary 2,5-hexanedione of workers in shoe and bag factories
    • Saito I, Shibata E. Hisanaga N, Takeuchi Y, Huang J. Relationship between n-hexane and urinary 2,5-hexanedione of workers in shoe and bag factories. Jpn J Ind Health 1992; 34: 831.
    • (1992) Jpn J Ind Health , vol.34 , pp. 831
    • Saito, I.1    Shibata, E.2    Hisanaga, N.3    Takeuchi, Y.4    Huang, J.5
  • 37
    • 0345311942 scopus 로고
    • Physiological factors affecting the behaviour of organic solvent vapors in humans
    • Cheremisinoff PN, eds. Gulf Publishing Company, Houston, Texas
    • Sato A, Johanson G. Physiological factors affecting the behaviour of organic solvent vapors in humans. In: Cheremisinoff PN, eds. Encyclopedia of environmental control technology. Vol 7. High hazard pollutants. Gulf Publishing Company, Houston, Texas, 1995: 53-80.
    • (1995) Encyclopedia of Environmental Control Technology. Vol 7. High Hazard Pollutants , vol.7 , pp. 53-80
    • Sato, A.1    Johanson, G.2
  • 38
    • 0000004156 scopus 로고
    • Quantitative relations in the physiological constitutions of mammals
    • Adolph EF. Quantitative relations in the physiological constitutions of mammals. Sci 1949; 109: 579-585.
    • (1949) Sci , vol.109 , pp. 579-585
    • Adolph, E.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.