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Volumn 9, Issue 11, 1998, Pages 725-730

High plasma homocysteine: A risk factor for vascular disease in the elderly

Author keywords

Cardiovascular disease; Elderly; Folic acid; Homocysteine; Vitamin B12; Vitamin B6

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHIONINE; PYRIDOXINE;

EID: 0032424842     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019501-199809110-00004     Document Type: Review
Times cited : (14)

References (36)
  • 1
    • 0001010968 scopus 로고
    • Plasma homocysteine and cardiovascular disease
    • Francis RB Jr, editor. New York: Marcel Deckker Inc.
    • Ueland PM, Refsum H, Brattström L. Plasma homocysteine and cardiovascular disease. In: Francis RB Jr, editor. Atherosclerotic cardiovascular disease, hemostasis, and endothelial function. New York: Marcel Deckker Inc.; 1992. pp. 183-236. A most useful reference for all work on homocysteine and atherosclerosis until the date of publication (1992). It provides a broad outline of homocysteine biochemistry and metabolism, interrelationships with vitamin and essential enzymes and summarizes much of the earlier work on vascular disease.
    • (1992) Atherosclerotic Cardiovascular Disease, Hemostasis, and Endothelial Function , pp. 183-236
    • Ueland, P.M.1    Refsum, H.2    Brattström, L.3
  • 3
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995; 274:1049-1057. A useful meta-analysis of many of the studies relating homocysteine to vascular disorders.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 4
    • 0022471265 scopus 로고
    • Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease
    • Kang SS, Wong PW, Cook HY, Norusis M, Messer JV. Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease. J Clin Invest 1986; 77:1482-1486.
    • (1986) J Clin Invest , vol.77 , pp. 1482-1486
    • Kang, S.S.1    Wong, P.W.2    Cook, H.Y.3    Norusis, M.4    Messer, J.V.5
  • 6
    • 0027421353 scopus 로고
    • Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease
    • Kang SS, Passen EL, Ruggie N, Wong PWK, Sora H. Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease. Circulation 1993; 80:1463-1469.
    • (1993) Circulation , vol.80 , pp. 1463-1469
    • Kang, S.S.1    Passen, E.L.2    Ruggie, N.3    Wong, P.W.K.4    Sora, H.5
  • 7
    • 0026552225 scopus 로고
    • Hyperhomocysteinemia in stroke: Prevalence, cause and relationships to type of stroke and stroke risk factors
    • Brattström L, Lindgren A, Israelsson B, Malinow MR, Norrving B, Upson B, et al. Hyperhomocysteinemia in stroke: prevalence, cause and relationships to type of stroke and stroke risk factors. Eur J Clin Invest 1992; 22:214-221. Demonstrates the importance of homocysteine as a risk factor for stroke in the elderly and emphasizes the association between homocysteine, renal function and cofactors for homocysteine metabolism.
    • (1992) Eur J Clin Invest , vol.22 , pp. 214-221
    • Brattström, L.1    Lindgren, A.2    Israelsson, B.3    Malinow, M.R.4    Norrving, B.5    Upson, B.6
  • 8
    • 0027382008 scopus 로고
    • Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
    • Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993; 270:2693-2698. This study involved elderly subjects from the Framingham heart study and showed a strong association between plasma homocysteine, age and lower vitamin status. The high homocysteine levels seen in this population can be attributed to low vitamin status.
    • (1993) JAMA , vol.270 , pp. 2693-2698
    • Selhub, J.1    Jacques, P.F.2    Wilson, P.W.F.3    Rush, D.4    Rosenberg, I.H.5
  • 9
    • 0028600627 scopus 로고
    • Homocysteine and cysteine: Determinants of plasma levels in middle-aged and elderly subjects
    • 12, serum creatinine and multivitamin usage are the most important determinants of plasma homocysteine concentration in middle-aged and elderly randomly selected residents. The age-related increase in homocysteine may be linked to the age-related impairment of renal failure.
    • (1994) J Int Med , vol.236 , pp. 633-641
    • Brattström, L.1    Lindgren, A.2    Israelsson, B.3    Andersson, A.4    Hultberg, B.5
  • 10
    • 0028855901 scopus 로고
    • Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease
    • Robinson K, Mayer EL, Miller DP, Green R, van Lente F, Gupta A, et al. Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Circulation 1995; 92:2825-2830.
    • (1995) Circulation , vol.92 , pp. 2825-2830
    • Robinson, K.1    Mayer, E.L.2    Miller, D.P.3    Green, R.4    Van Lente, F.5    Gupta, A.6
  • 11
    • 0028788020 scopus 로고
    • Total plasma homocysteine and cardiovascular risk profile: The Hordaland Homocysteine Study
    • Nygård O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, et al. Total plasma homocysteine and cardiovascular risk profile: The Hordaland Homocysteine Study. JAMA 1995; 274:1526-1533. This study aimed to assess the relation between established cardiovascular risk factors and plasma homocysteine. Elevated plasma homocysteine was associated with other major risk factors for cardiovascular disease, namely male sex, old age, hypertension, hypercholesterolemia and sedentary lifestyle. This study is particularly important because it is very comprehensive and involves a large number of participants (7591 men and 8585 women).
    • (1995) JAMA , vol.274 , pp. 1526-1533
    • Nygård, O.1    Vollset, S.E.2    Refsum, H.3    Stensvold, I.4    Tverdal, A.5    Nordrehaug, J.E.6
  • 13
    • 0026691381 scopus 로고
    • Age dependency of cystathionine beta-synthase activity in human fibroblasts in homocyst(e)inemia and atherosclerotic vascular disease
    • Nordström M, Kjellström T. Age dependency of cystathionine beta-synthase activity in human fibroblasts in homocyst(e)inemia and atherosclerotic vascular disease. Atherosclerosis 1992; 94:213-221.
    • (1992) Atherosclerosis , vol.94 , pp. 213-221
    • Nordström, M.1    Kjellström, T.2
  • 14
    • 0019831768 scopus 로고
    • Effect of chronologic age on induction of cystathionine synthase, uroporphyrinogen I synthase, and glucose-6-phosphate dehydrogenase activities in lymphocytes
    • Gartler SM, Hornug SK, Motulsky AG. Effect of chronologic age on induction of cystathionine synthase, uroporphyrinogen I synthase, and glucose-6-phosphate dehydrogenase activities in lymphocytes. Proc Natl Acad Sci USA 1981; 78:1916-1919.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 1916-1919
    • Gartler, S.M.1    Hornug, S.K.2    Motulsky, A.G.3
  • 15
    • 0017284939 scopus 로고
    • The pathogenesis of coronary artery disease: A possible role for methionine metabolism
    • Wilcken DE, Wilcken B. The pathogenesis of coronary artery disease: a possible role for methionine metabolism. J Clin Invest 1976; 57:1079-1082.
    • (1976) J Clin Invest , vol.57 , pp. 1079-1082
    • Wilcken, D.E.1    Wilcken, B.2
  • 17
    • 0025095390 scopus 로고
    • Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment
    • Brattström L, Israelsson B, Norrving B, Bergqvist D, Thörne J, Hultberg B, et al. Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment. Atherosclerosis 1990; 81:51-60.
    • (1990) Atherosclerosis , vol.81 , pp. 51-60
    • Brattström, L.1    Israelsson, B.2    Norrving, B.3    Bergqvist, D.4    Thörne, J.5    Hultberg, B.6
  • 18
    • 0030971062 scopus 로고    scopus 로고
    • Homocysteine and thrombotic disease
    • D'Angelo A, Selhub J. Homocysteine and thrombotic disease. Blood 1997; 90:1-11. This article is a general review of the association between homocysteine and various forms of thrombotic diseases.
    • (1997) Blood , vol.90 , pp. 1-11
    • D'Angelo, A.1    Selhub, J.2
  • 20
    • 0026036480 scopus 로고
    • The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease
    • Taylor LM Jr, DeFrang RD, Harris EJ Jr, Porter JM. The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease. J Vasc Surg 1991; 13:128-136.
    • (1991) J Vasc Surg , vol.13 , pp. 128-136
    • Taylor L.M., Jr.1    DeFrang, R.D.2    Harris E.J., Jr.3    Porter, J.M.4
  • 23
    • 0028219672 scopus 로고
    • Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study
    • Alfthan G, Pekkanen J, Jauhiainen M, Pitkaniemi J, Karvonen M, Tuomilehto J, et al. Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis 1994; 106:9-19.
    • (1994) Atherosclerosis , vol.106 , pp. 9-19
    • Alfthan, G.1    Pekkanen, J.2    Jauhiainen, M.3    Pitkaniemi, J.4    Karvonen, M.5    Tuomilehto, J.6
  • 24
    • 1842331509 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for vascular disease: The European Concerted Action Project
    • Graham IM, Daly LE, Refsum HM, Robinson K, Brattström LE, Ueland PM, et al. Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project. JAMA 1997; 277:1775-1781. This is a large multicenter case-control study that aimed to study the role of plasma homocysteine as a risk factor for vascular disease and the interaction with other risk factors. Graham and co-workers found that high homocysteine levels potentiate the cardiovascular adverse effects of smoking and diabetes.
    • (1997) JAMA , vol.277 , pp. 1775-1781
    • Graham, I.M.1    Daly, L.E.2    Refsum, H.M.3    Robinson, K.4    Brattström, L.E.5    Ueland, P.M.6
  • 25
    • 0030956453 scopus 로고    scopus 로고
    • Association between plasma homocysteine and extracranial carotid arterial disease in older persons
    • Aronow WS, Ahn C, Schoenfeld MR. Association between plasma homocysteine and extracranial carotid arterial disease in older persons. Am J Cardiol 1997; 79:1432-1433.
    • (1997) Am J Cardiol , vol.79 , pp. 1432-1433
    • Aronow, W.S.1    Ahn, C.2    Schoenfeld, M.R.3
  • 26
    • 0030694694 scopus 로고    scopus 로고
    • Association between plasma homocysteine and coronary artery disease in older persons
    • Aronow WS, Ahn C. Association between plasma homocysteine and coronary artery disease in older persons. Am J Cardiol 1997; 80:1216-1218.
    • (1997) Am J Cardiol , vol.80 , pp. 1216-1218
    • Aronow, W.S.1    Ahn, C.2
  • 28
    • 0029911977 scopus 로고    scopus 로고
    • Homocysteinemia and vascular disease in end-stage renal disease
    • Dennis VW, Robinson K. Homocysteinemia and vascular disease in end-stage renal disease. Kidney Int 1996; 57 (suppl):S11-S17.
    • (1996) Kidney Int , vol.57 , Issue.SUPPL.
    • Dennis, V.W.1    Robinson, K.2
  • 29
    • 0031914677 scopus 로고    scopus 로고
    • Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease
    • Moustapha A, Naso A, Nahlawi M, Gupta A, Arheart KL, Jacobsen DW, et al. Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease. Circulation 1998, 97:138-141.
    • (1998) Circulation , vol.97 , pp. 138-141
    • Moustapha, A.1    Naso, A.2    Nahlawi, M.3    Gupta, A.4    Arheart, K.L.5    Jacobsen, D.W.6
  • 30
    • 0030188563 scopus 로고    scopus 로고
    • The oxidant stress of hyperhomocyst(e)inemia
    • Loscalzo J. The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest 1996; 98:5-7.
    • (1996) J Clin Invest , vol.98 , pp. 5-7
    • Loscalzo, J.1
  • 32
    • 0031018333 scopus 로고    scopus 로고
    • Hyperhomocyst(e)inemia is associated with impaired endothelial-dependent vasodilation in humans
    • Tawakol A, Omland T, Gerhard M, Wu JT, Creager MA. Hyperhomocyst(e)inemia is associated with impaired endothelial-dependent vasodilation in humans. Circulation 1997; 95:1119-1121.
    • (1997) Circulation , vol.95 , pp. 1119-1121
    • Tawakol, A.1    Omland, T.2    Gerhard, M.3    Wu, J.T.4    Creager, M.A.5
  • 34
    • 0013327427 scopus 로고    scopus 로고
    • Vitamins and progression of atherosclerosis in hyperhomocyst(e)inaemia
    • Peterson JC, Spence JD. Vitamins and progression of atherosclerosis in hyperhomocyst(e)inaemia. Lancet 1998; 351:263.
    • (1998) Lancet , vol.351 , pp. 263
    • Peterson, J.C.1    Spence, J.D.2
  • 36
    • 0028957460 scopus 로고
    • Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease
    • Van den Berg M, Boers GH, Franken DG, Blom HJ, Van Kamp GJ, Jakobs C, et al. Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease. Eur J Clin Invest 1995; 25:176-181.
    • (1995) Eur J Clin Invest , vol.25 , pp. 176-181
    • Van Den Berg, M.1    Boers, G.H.2    Franken, D.G.3    Blom, H.J.4    Van Kamp, G.J.5    Jakobs, C.6


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