Different left ventricular relaxation parameters in isolated working rat and guinea pig hearts: Influence of preload, afterload, temperature, and isoprenaline

International Journal of Cardiac Imaging

Volumn 14, Issue 4, 1998, Pages 229-240

  Langer, Stefan F J ^a   Schmidt, Hanno D ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Myocardial contraction; Peak negative dP dt; Regression analysis; Relaxation time constant; Ventricular relaxation

Indexed keywords

ISOPRENALINE;

ANIMAL EXPERIMENT; ARTICLE; CORRELATION FUNCTION; GUINEA PIG; HEART AFTERLOAD; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE RELAXATION; HEART RATE; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEMODYNAMIC PARAMETERS; ISOLATED HEART; NONHUMAN; RAT; REGRESSION ANALYSIS; TEMPERATURE;

ANIMALS; CARDIOTONIC AGENTS; GUINEA PIGS; HEART; ISOPROTERENOL; MYOCARDIAL CONTRACTION; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 0032424759     PISSN: 01679899     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006083306901     Document Type: Article

References (45)

1. Gaasch WH, Blaustein AS, Andrias CW, Donahue RP, Avitall B. Myocardial relaxation. II. Hemodynamic determinants of rate of left ventricular isovolumic pressure decline. Am J Physiol 1980; 239: H1-H6.
2. Gaasch WH, Carroll JD, Blaustein AS, Bing OH. Myocardial relaxation: effects of preload on the time course of isovolumetric relaxation. Circulation 1986; 73: 1073-41.
3. Gleason WL, Braunwald E. Studies on the first derivative of the ventricular pressure pulse in man. J Clin Invest 1962; 41: 80-91.
4. Hori M, Inoue M, Fukunami M, Kitakaze M, Ishida Y, Tsujioka K et al. An increase in afterload augments ventricular relaxation rate in isolated perfused canine hearts. Cardiovasc Res 1985; 19: 649-54.
5. Karliner JS, LeWinter MM, Mahler F, Engler R, O'Rourke RA. Pharmacologic and hemodynamic influences on the rate of isovolumic left ventricular relaxation in the normal conscious dog. J Clin Invest 1977; 60: 511-21.
6. Kettünen R, Timisjärvi J, Rämö P, Koüvalainen E, Heikkilä J, Hirvonen L. Time constant of isovolumic pressure fall in the intact canine ventricle. Cardiovasc Res 1986; 20: 698-704.
7. Su JB, Hittinger L, Laplace M, Crozatier B. Loading determinants of isovolumic pressure fall in closed-chest dogs. Am J Physiol 1991; 260: H690-H697.
8. Weisfeldt ML, Scully HE, Frederiksen J, Rubenstein JJ, Pohost GM, Beierholm E et al. Hemodynamic determinants of maximum negative dLVP/dt and periods of diastole. Am J Physiol 1974; 227: 613-21.
9. Rousseau MF, Veriter C, Detry JM, Brasseur L, Pouleur H. Impaired early left ventricular relaxation in coronary artery disease: effects of intracoronary Nifedipine. Circulation 1980; 62: 764-72.
10. Tobias AH, Slinker BK, Kirkpatrick RD, Campbell KB. Mechanical determinants of left ventricular relaxation in isovolumically beating hearts. Am J Physiol 1995; 268: H170-H177.
11. Frederiksen JW, Weiss JL, Weisfeldt ML. Time constant of isovolumetric pressure fall: determinants in the working left ventricle. Am J Physiol 1978; 235: H701-H706.
12. Hori M, Kitakaze M, Ishida Y, Fukunami M, Kitabatake A, Inoue M et al. Delayed end ejection increased isovolumic ventricular relaxation rate in isolated perfused canine hearts. Circ Res 1991; 68: 300-8.
13. Starling MR, Montgomery DG, Mancini GB, Walsh RA. Load independence of the rate of isovolumic relaxation in man. Circulation 1987; 76: 1274-81.
14. Weiss JL, Frederiksen JW, Weisfeldt ML. Hemodynamic determinants of the time-course of fall in canine left ventricular pressure. J Clin Invest 1976; 58: 751-60.
15. Raya TE, Gay RG, Lancaster L, Aguirre M, Moffett C, Goldman S. Serial changes in left ventricular relaxation and chamber stiffness after large myocardial infarction in rats. Circulation 1988; 77: 1424-31.
16. Grocott-Mason R, Anning P, Evans H, Lewis MJ, Shah AM. Modulation of left ventricular relaxation in isolated ejecting heart by endogenous nitric oxide. Am J Physiol 1994; 267: H1804-H1813.
17. Martín G, Gimeno JV, Ramirez A, Cosín J, Báguena J. Effects of high-frequency harmonics on cardiac relaxation indices. Am J Physiol 1981; 240: H669-H675.
18. Abel FL. Maximal negative dP/dt as an indicator of end of systole. Am J Physiol 1981; 240: H676-H679.
19. Langer SF. Efficient exponential regression with exact fiducial limits to fit cardiac pressure data. Comput Meth Progs Biomed 1997; 53: 57-64.
20. Nelder JA, Mead R. A simplex method for function minimization. Computer J 1965; 7: 308-13.
21. Motulsky HJ, Ransnas LA. Fitting curves to data using nonlinear regression: a practical and nonmathematical review. FASEB J 1987; 1: 365-74.
22. Kendall MG. Rank Correlation Methods. 4th ed. London: Griffin & Co, 1970, pp. 38-41.
23. Glasser GJ, Winter RF. Critical values of rank correlation for testing the hypothesis of independence. Biometrika 1961; 48: 444-8 (Table 3, p. 447).
24. Yano M, Kohno M, Konishi M, Takahashi T, Seki K, Matsuzaki M. Influence of left ventricular nonuniformity on afterload dependent relaxation in intact dogs. Am J Physiol 1994; 267: H148-H154.
25. Mirsky I. Assessment of diastolic function: suggested methods and future considerations. Circulation 1984; 69: 836-41.
26. Raff GL, Glantz SA. Volume loading slows left ventricular isovolumetric relaxation rate. Circ Res 1981; 48: 813-24.
27. Parmley WW, Sonnenblick EH. Relation between mechanics of contraction and relaxation in mammalian cardiac muscle. Am J Physiol 1969; 216: 1084-91.
28. Schafer S, Schlack W, Kelm M, Deussen A, Strauer BE. Characterisation of left ventricular relaxation in the isolated guinea pig heart. Res Exp Med (Berl) 1996; 196: 261-73.
29. Hori M, Inoue M, Kitakaze M, Tsujioka K, Ishida Y, Fukunami M et al. Loading sequence is a major determinant of afterload-dependent relaxation in intact canine heart. Am J Physiol 1985; 249: H747-H754.
30. Gillebert TC, Lew WY. Nonuniformity and volume loading independently influence isovolumic relaxation rates. Am J Physiol 1989; 257: H1927-H1935.
31. Yellin EL, Hori M, Yoran C, Sonnenblick EH, Gabbay S, Frater RW. Left ventricular relaxation in the filling and nonfilling intact canine heart. Am J Physiol 1986; 250: H620-H629.
32. Zatko FJ, Martin P, Bahler RC. Time course of systolic loading is an important determinant of ventricular relaxation. Am J Physiol 1987: 252: H461-H466.
33. Schafer S, Fiedler VB, Thamer V Afterload dependent prolongation of left ventricular relaxation: importance of asynchrony. Cardiovasc Res 1992; 26: 631-7.
34. Martin G, Gimeno JV, Cosin J, Guillem MI. Time constant of isovolumic pressure fall: new numerical approaches and significance. Am J Physiol 1984; 247: H283-H294.
35. Leite-Moreira AF, Gillebert TC. Nonuniform course of left ventricular pressure fall and its regulation by load and contractile state. Circulation 1994; 90: 2481-91.
36. Schiereck P, Nieuwenhuijs JH, de Beer EL, van Hessen MW, van Kaam FA, Crowe A. Relaxation time constant of isolated rabbit left ventricle. Am J Physiol 1987; 253: H512-H518.
37. Zile MR, Conrad CH, Gaasch WH, Robinson KG, Bing OH. Preload does not affect relaxation rate in normal, hypoxic, or hypertrophic myocardium. Am J Physiol 1990; 258: H191-H197.
38. Thompson DS, Wilmhurst P, Juul SM, Waldron CB, Jenkins BS, Coltart DJ. Pressure-derived indices of left ventricular isovolumic relaxation in patients with hypertrophic cardiomyopathy. Br Heart J 1983; 49: 259-67.
39. Lew WY. Evaluation of left ventricular diastolic function. Circulation 1989; 79: 1393-7.
40. Thompson DS, Waldron CB, Juul SM, Naqvi N, Swanton RH, Coltart DJ et al. Analysis of left ventricular pressure during isovolumetric relaxation in coronary artery disease. Circulation 1982; 65: 690-7.
41. Mann T, Goldberg S, Mudge G Jr, Grossman W. Factors contributing to altered left ventricular diastolic properties during angina pectoris. Circulation 1979; 59: 14-20.
42. Zile MR, Gaasch WH. Load-dependent left ventricular relaxation in conscious dogs. Am J Physiol 1991; 261: H691-H699.
43. Parsons C, Porter KR. Muscle relaxation: evidence for an intrafibrillar restoring force in vertebrate striated muscle. Science 1966; 153: 426-7.
44. Brutsaert DL, Paulus WJ. Contraction and Relaxation of the Heart as Muscle and Pump. Int Rev Physiol (Cardiovascular Physiology III) 1979; 18: 1-31.
45. Ruttley MS, Adams DF, Cohn PF, Abrams HL. Shape and volume changes during 'isovolumetric relaxation' in normal and asynergic ventricles. Circulation 1974; 50: 306-16.